Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130112063> ?p ?o ?g. }
- W2130112063 endingPage "4225" @default.
- W2130112063 startingPage "4217" @default.
- W2130112063 abstract "Abstract Bronchial asthma is an increasingly common disorder that remains poorly understood and difficult to manage. The disease is characterized by airway hyperresponsiveness, chronic inflammation, and mucus overproduction. Based on the finding that leukotriene B4 receptor 1 (BLT1) is expressed highly in Th2 lymphocytes, we analyzed the roles of BLT1 using an OVA-induced bronchial asthma model. BLT1-null mice did not develop airway hyperresponsiveness, eosinophilic inflammation, and hyperplasia of goblet cells. Attenuated symptoms were accompanied by reduced IgE production, and accumulation of IL-5 and IL-13 in bronchoalveolar lavage fluid, suggesting attenuated Th2-type immune response in BLT1-null mice. Peribronchial lymph node cells of sensitized BLT1-null mice showed much attenuated proliferation and production of Th2 cytokines upon re-stimulation with Ag in vitro. Thus, LTB4-BLT1 axis is required for the development of Th2-type immune response, and blockade of LTB4 functions through BLT1 would be novel and useful in the effort to ameliorate bronchial asthma and related Th2-biased immune disorders." @default.
- W2130112063 created "2016-06-24" @default.
- W2130112063 creator A5008934626 @default.
- W2130112063 creator A5012512566 @default.
- W2130112063 creator A5017733651 @default.
- W2130112063 creator A5057803965 @default.
- W2130112063 creator A5058137680 @default.
- W2130112063 creator A5066177154 @default.
- W2130112063 creator A5067009952 @default.
- W2130112063 creator A5076042354 @default.
- W2130112063 date "2005-10-01" @default.
- W2130112063 modified "2023-10-07" @default.
- W2130112063 title "Absence of Leukotriene B4 Receptor 1 Confers Resistance to Airway Hyperresponsiveness and Th2-Type Immune Responses" @default.
- W2130112063 cites W1521516424 @default.
- W2130112063 cites W1544502281 @default.
- W2130112063 cites W1566553022 @default.
- W2130112063 cites W1672565987 @default.
- W2130112063 cites W1879920813 @default.
- W2130112063 cites W1980832959 @default.
- W2130112063 cites W2007187686 @default.
- W2130112063 cites W2007877336 @default.
- W2130112063 cites W2015006881 @default.
- W2130112063 cites W2015184057 @default.
- W2130112063 cites W2024176341 @default.
- W2130112063 cites W2032253262 @default.
- W2130112063 cites W2040243459 @default.
- W2130112063 cites W2044029073 @default.
- W2130112063 cites W2047267265 @default.
- W2130112063 cites W2053071361 @default.
- W2130112063 cites W2063460615 @default.
- W2130112063 cites W2071673490 @default.
- W2130112063 cites W2078223923 @default.
- W2130112063 cites W2084225449 @default.
- W2130112063 cites W2095352157 @default.
- W2130112063 cites W2097407366 @default.
- W2130112063 cites W2101035994 @default.
- W2130112063 cites W2106234499 @default.
- W2130112063 cites W2106327430 @default.
- W2130112063 cites W2108187252 @default.
- W2130112063 cites W2116105539 @default.
- W2130112063 cites W2124566107 @default.
- W2130112063 cites W2124853474 @default.
- W2130112063 cites W2130414223 @default.
- W2130112063 cites W2130773324 @default.
- W2130112063 cites W2131247421 @default.
- W2130112063 cites W2140492247 @default.
- W2130112063 cites W2140612321 @default.
- W2130112063 cites W2140686309 @default.
- W2130112063 cites W2140942460 @default.
- W2130112063 cites W2143937011 @default.
- W2130112063 cites W2147917304 @default.
- W2130112063 cites W2155666356 @default.
- W2130112063 cites W2163544819 @default.
- W2130112063 cites W2167243592 @default.
- W2130112063 cites W2169470519 @default.
- W2130112063 cites W2170049370 @default.
- W2130112063 cites W2170690637 @default.
- W2130112063 cites W2170751128 @default.
- W2130112063 cites W4254446533 @default.
- W2130112063 cites W4293247451 @default.
- W2130112063 doi "https://doi.org/10.4049/jimmunol.175.7.4217" @default.
- W2130112063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16177061" @default.
- W2130112063 hasPublicationYear "2005" @default.
- W2130112063 type Work @default.
- W2130112063 sameAs 2130112063 @default.
- W2130112063 citedByCount "156" @default.
- W2130112063 countsByYear W21301120632012 @default.
- W2130112063 countsByYear W21301120632013 @default.
- W2130112063 countsByYear W21301120632014 @default.
- W2130112063 countsByYear W21301120632015 @default.
- W2130112063 countsByYear W21301120632016 @default.
- W2130112063 countsByYear W21301120632017 @default.
- W2130112063 countsByYear W21301120632018 @default.
- W2130112063 countsByYear W21301120632019 @default.
- W2130112063 countsByYear W21301120632020 @default.
- W2130112063 countsByYear W21301120632021 @default.
- W2130112063 countsByYear W21301120632022 @default.
- W2130112063 countsByYear W21301120632023 @default.
- W2130112063 crossrefType "journal-article" @default.
- W2130112063 hasAuthorship W2130112063A5008934626 @default.
- W2130112063 hasAuthorship W2130112063A5012512566 @default.
- W2130112063 hasAuthorship W2130112063A5017733651 @default.
- W2130112063 hasAuthorship W2130112063A5057803965 @default.
- W2130112063 hasAuthorship W2130112063A5058137680 @default.
- W2130112063 hasAuthorship W2130112063A5066177154 @default.
- W2130112063 hasAuthorship W2130112063A5067009952 @default.
- W2130112063 hasAuthorship W2130112063A5076042354 @default.
- W2130112063 hasBestOaLocation W21301120631 @default.
- W2130112063 hasConcept C126322002 @default.
- W2130112063 hasConcept C141105273 @default.
- W2130112063 hasConcept C159654299 @default.
- W2130112063 hasConcept C203014093 @default.
- W2130112063 hasConcept C2776042228 @default.
- W2130112063 hasConcept C2776685179 @default.
- W2130112063 hasConcept C2776914184 @default.
- W2130112063 hasConcept C2777714996 @default.
- W2130112063 hasConcept C2777961210 @default.
- W2130112063 hasConcept C71924100 @default.