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• W2130125439 endingPage "468" @default.
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• W2130125439 abstract "ABSTRACT Typhoid fever remains a major health problem in developing countries. Young children are at high risk, and a vaccine effective for this age group is urgently needed. Purified capsular polysaccharide from Salmonella enterica serovar Typhi (Vi) is licensed as a vaccine, providing 50 to 70% protection in individuals older than 5 years. However, this vaccine is ineffective in infants. Vi conjugated to a carrier protein (i.e., an exoprotein A mutant from Pseudomonas aeruginosa [rEPA]) is highly immunogenic, provides long-term protection, and shows more than 90% protective efficacy in children 2 to 5 years old. Here, we describe an alternative glycoconjugate vaccine for S . Typhi, Vi-CRM 197 , where Vi was obtained from Citrobacter freundii WR7011 and CRM 197 , the mutant diphtheria toxin protein, was used as the carrier. We investigated the optimization of growth conditions for Vi production from C. freundii WR7011 and the immunogenicity of Vi-CRM 197 conjugates in mice. The optimal saccharide/protein ratio of the glycoconjugates was identified for the best antibody production. We also demonstrated the ability of this new vaccine to protect mice against challenge with Vi-positive Salmonella enterica serovar Typhimurium." @default.
• W2130125439 created "2016-06-24" @default.
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• W2130125439 date "2011-03-01" @default.
• W2130125439 modified "2023-09-25" @default.
• W2130125439 title "Evaluation of the Immunogenicity and Biological Activity of the <i>Citrobacter freundii</i> Vi-CRM ₁₉₇ Conjugate as a Vaccine for <i>Salmonella enterica</i> Serovar Typhi" @default.
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• W2130125439 doi "https://doi.org/10.1128/cvi.00387-10" @default.
• W2130125439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3067394" @default.
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