Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130135981> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2130135981 abstract "In vitro, cytokines like interleukin-1-beta (IL-1-B) and tumour necrosis factor-alpha (TNF-A) inhibit insulin release and can destroy islet B-cells. We measured blood levels of IL-1-B, TNF-A, and islet cell antibody (ICA) in 20 children with IDDM, 20 of their non-diabetic siblings, 20 children with thalassemia major on long-term hypertransfusion therapy and iron chelation, and 10 normal age-matched children. In the non-diabetic and thalassemic children we investigated the early phase of insulin release after i.v. glucose (0.5 g/kg, 30 per cent solution) and evaluated tolerance to oral glucose (1.75 g/ kg). Circulating IL-1-B and TNF-A concentrations were significantly higher in IDDM-siblings (33.7 +/- 12.7 pg/ml and 655 +/- 165 pg/ml, respectively) v. normal children (21.1 +/- 6.4 pg/ml and 383 +/- 122 pg/ml, respectively). Thalassemic children had no detectable circulating ICA. The prevalence of ICA was 30 per cent in children with IDDM and 60 per cent of their siblings. Impaired oral glucose tolerance was detected in five children with thalassemia (25 per cent), but in none of the IDDM-siblings. The early phase of insulin release was significantly depressed in thalassemic children (peak insulin = 29.2 +/- 5.1 mIU/ml) v. normal children (52.3 +/- 9.5 mIU/ml) and IDDM-siblings (45.3 +/- 12.4 mIU/ml). It appears that thalassemic children had significantly decreased insulin secretion and impaired glucose tolerance, however, the mechanism of B-cell dysfunction is not mediated by ICA nor by cytokines." @default.
- W2130135981 created "2016-06-24" @default.
- W2130135981 creator A5000336841 @default.
- W2130135981 creator A5037343692 @default.
- W2130135981 creator A5038184776 @default.
- W2130135981 creator A5038558415 @default.
- W2130135981 creator A5045595746 @default.
- W2130135981 creator A5048664693 @default.
- W2130135981 creator A5068718149 @default.
- W2130135981 creator A5087400838 @default.
- W2130135981 date "1996-12-01" @default.
- W2130135981 modified "2023-10-06" @default.
- W2130135981 title "Interleukin-1-beta, tumour necrosis factor-alpha, islet-cell antibody, and insulin secretion in children with thalassemia major on long term blood transfusion" @default.
- W2130135981 doi "https://doi.org/10.1093/tropej/42.6.362" @default.
- W2130135981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9009565" @default.
- W2130135981 hasPublicationYear "1996" @default.
- W2130135981 type Work @default.
- W2130135981 sameAs 2130135981 @default.
- W2130135981 citedByCount "9" @default.
- W2130135981 countsByYear W21301359812013 @default.
- W2130135981 countsByYear W21301359812018 @default.
- W2130135981 crossrefType "journal-article" @default.
- W2130135981 hasAuthorship W2130135981A5000336841 @default.
- W2130135981 hasAuthorship W2130135981A5037343692 @default.
- W2130135981 hasAuthorship W2130135981A5038184776 @default.
- W2130135981 hasAuthorship W2130135981A5038558415 @default.
- W2130135981 hasAuthorship W2130135981A5045595746 @default.
- W2130135981 hasAuthorship W2130135981A5048664693 @default.
- W2130135981 hasAuthorship W2130135981A5068718149 @default.
- W2130135981 hasAuthorship W2130135981A5087400838 @default.
- W2130135981 hasBestOaLocation W21301359811 @default.
- W2130135981 hasConcept C126322002 @default.
- W2130135981 hasConcept C134018914 @default.
- W2130135981 hasConcept C159654299 @default.
- W2130135981 hasConcept C165220095 @default.
- W2130135981 hasConcept C203014093 @default.
- W2130135981 hasConcept C2776828364 @default.
- W2130135981 hasConcept C2777391703 @default.
- W2130135981 hasConcept C2777799968 @default.
- W2130135981 hasConcept C2779306644 @default.
- W2130135981 hasConcept C2780609358 @default.
- W2130135981 hasConcept C555293320 @default.
- W2130135981 hasConcept C71924100 @default.
- W2130135981 hasConceptScore W2130135981C126322002 @default.
- W2130135981 hasConceptScore W2130135981C134018914 @default.
- W2130135981 hasConceptScore W2130135981C159654299 @default.
- W2130135981 hasConceptScore W2130135981C165220095 @default.
- W2130135981 hasConceptScore W2130135981C203014093 @default.
- W2130135981 hasConceptScore W2130135981C2776828364 @default.
- W2130135981 hasConceptScore W2130135981C2777391703 @default.
- W2130135981 hasConceptScore W2130135981C2777799968 @default.
- W2130135981 hasConceptScore W2130135981C2779306644 @default.
- W2130135981 hasConceptScore W2130135981C2780609358 @default.
- W2130135981 hasConceptScore W2130135981C555293320 @default.
- W2130135981 hasConceptScore W2130135981C71924100 @default.
- W2130135981 hasLocation W21301359811 @default.
- W2130135981 hasLocation W21301359812 @default.
- W2130135981 hasOpenAccess W2130135981 @default.
- W2130135981 hasPrimaryLocation W21301359811 @default.
- W2130135981 hasRelatedWork W2024312973 @default.
- W2130135981 hasRelatedWork W2031301348 @default.
- W2130135981 hasRelatedWork W2039773086 @default.
- W2130135981 hasRelatedWork W2051806208 @default.
- W2130135981 hasRelatedWork W2056853029 @default.
- W2130135981 hasRelatedWork W2072849820 @default.
- W2130135981 hasRelatedWork W2092346917 @default.
- W2130135981 hasRelatedWork W2096706659 @default.
- W2130135981 hasRelatedWork W2156180953 @default.
- W2130135981 hasRelatedWork W2410681479 @default.
- W2130135981 isParatext "false" @default.
- W2130135981 isRetracted "false" @default.
- W2130135981 magId "2130135981" @default.
- W2130135981 workType "article" @default.