FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130147474> ?p ?o ?g. }

• W2130147474 endingPage "1626" @default.
• W2130147474 startingPage "1618" @default.
• W2130147474 abstract "The MICs and MBCs of benzylpenicillin, ampicillin, cefotaxime, and methicillin were evaluated against a Streptococcus (Enterococcus) faecium wild-type strain and against three mutants hyperproducing PBP 5 in cells incubated at both optimal and suboptimal temperatures. In the wild-type strain grown at optimal temperature, the MBCs of all beta-lactams were significantly greater than the MICs (bacteriostatic effect). As opposed to this, in the same cells grown at suboptimal temperature and in the mutants hyperproducing PBP 5 at all temperatures, the MICs of all antibiotics coincided with the MBCs (bactericidal effect). Under all conditions in which the MIC and MBC were the same, with all antibiotics, growth inhibition occurred only at the minimal concentration saturating all penicillin-binding proteins (PBPs) (or at higher concentrations). On the contrary, under conditions in which the MIC was lower than the MBC, only some of the PBPs were saturated (or bound) at both the MIC and the MBC, PBP 5 in no case being either saturated or bound. Under all conditions in which saturation of all PBPs was needed for growth inhibition, cells died at all antibiotic MBCs with kinetics which were much faster than those with which they died at the MBCs under conditions in which not all PBPs were saturated (or bound). In addition, under the former conditions, antibiotic concentrations above the MBCs did not significantly accelerate cell death kinetics, while under the latter conditions there was an acceleration in kinetics with increasing antibiotic concentrations up to full saturation of PBPs. It is suggested that the killing that occurs when all PBPs are saturated is a direct consequence of inactivation of PBP functions, while killing occurring when only some of them are saturated or bound is also (or mainly) an indirect consequence of inability of cells to grow and that, in S. faecium, the targets for growth inhibition and cell killing reside in different PBPs: for the latter effect, inactivation of one (or more) of the high-molecular-weight PBPs is sufficient, whereas in the former case inactivation of PBP 5 is necessary (after saturation of all other PBPs)." @default.
• W2130147474 created "2016-06-24" @default.
• W2130147474 creator A5026163102 @default.
• W2130147474 creator A5029943309 @default.
• W2130147474 creator A5031509045 @default.
• W2130147474 creator A5036749845 @default.
• W2130147474 creator A5073541528 @default.
• W2130147474 date "1987-10-01" @default.
• W2130147474 modified "2023-09-26" @default.
• W2130147474 title "Bacteriostatic and bactericidal activities of beta-lactams against Streptococcus (Enterococcus) faecium are associated with saturation of different penicillin-binding proteins" @default.
• W2130147474 cites W1511623606 @default.
• W2130147474 cites W1941417242 @default.
• W2130147474 cites W1971299795 @default.
• W2130147474 cites W1978311604 @default.
• W2130147474 cites W1989423690 @default.
• W2130147474 cites W2037560652 @default.
• W2130147474 cites W2061489426 @default.
• W2130147474 cites W2070514965 @default.
• W2130147474 cites W2074299612 @default.
• W2130147474 cites W2084312473 @default.
• W2130147474 cites W2131650784 @default.
• W2130147474 cites W2132050847 @default.
• W2130147474 cites W2163279482 @default.
• W2130147474 cites W3021014932 @default.
• W2130147474 cites W4212910766 @default.
• W2130147474 cites W4240574691 @default.
• W2130147474 doi "https://doi.org/10.1128/aac.31.10.1618" @default.
• W2130147474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/175002" @default.
• W2130147474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3435109" @default.
• W2130147474 hasPublicationYear "1987" @default.
• W2130147474 type Work @default.
• W2130147474 sameAs 2130147474 @default.
• W2130147474 citedByCount "25" @default.
• W2130147474 countsByYear W21301474742012 @default.
• W2130147474 countsByYear W21301474742015 @default.
• W2130147474 countsByYear W21301474742017 @default.
• W2130147474 crossrefType "journal-article" @default.
• W2130147474 hasAuthorship W2130147474A5026163102 @default.
• W2130147474 hasAuthorship W2130147474A5029943309 @default.
• W2130147474 hasAuthorship W2130147474A5031509045 @default.
• W2130147474 hasAuthorship W2130147474A5036749845 @default.
• W2130147474 hasAuthorship W2130147474A5073541528 @default.
• W2130147474 hasBestOaLocation W21301474742 @default.
• W2130147474 hasConcept C104317684 @default.
• W2130147474 hasConcept C174802600 @default.
• W2130147474 hasConcept C176947019 @default.
• W2130147474 hasConcept C26381139 @default.
• W2130147474 hasConcept C2776021129 @default.
• W2130147474 hasConcept C2776341680 @default.
• W2130147474 hasConcept C2776368647 @default.
• W2130147474 hasConcept C2776653525 @default.
• W2130147474 hasConcept C2777677444 @default.
• W2130147474 hasConcept C2777894859 @default.
• W2130147474 hasConcept C2778663903 @default.
• W2130147474 hasConcept C2778719061 @default.
• W2130147474 hasConcept C2778910516 @default.
• W2130147474 hasConcept C2779074116 @default.
• W2130147474 hasConcept C2780585763 @default.
• W2130147474 hasConcept C501593827 @default.
• W2130147474 hasConcept C547475151 @default.
• W2130147474 hasConcept C55493867 @default.
• W2130147474 hasConcept C86803240 @default.
• W2130147474 hasConcept C89423630 @default.
• W2130147474 hasConceptScore W2130147474C104317684 @default.
• W2130147474 hasConceptScore W2130147474C174802600 @default.
• W2130147474 hasConceptScore W2130147474C176947019 @default.
• W2130147474 hasConceptScore W2130147474C26381139 @default.
• W2130147474 hasConceptScore W2130147474C2776021129 @default.
• W2130147474 hasConceptScore W2130147474C2776341680 @default.
• W2130147474 hasConceptScore W2130147474C2776368647 @default.
• W2130147474 hasConceptScore W2130147474C2776653525 @default.
• W2130147474 hasConceptScore W2130147474C2777677444 @default.
• W2130147474 hasConceptScore W2130147474C2777894859 @default.
• W2130147474 hasConceptScore W2130147474C2778663903 @default.
• W2130147474 hasConceptScore W2130147474C2778719061 @default.
• W2130147474 hasConceptScore W2130147474C2778910516 @default.
• W2130147474 hasConceptScore W2130147474C2779074116 @default.
• W2130147474 hasConceptScore W2130147474C2780585763 @default.
• W2130147474 hasConceptScore W2130147474C501593827 @default.
• W2130147474 hasConceptScore W2130147474C547475151 @default.
• W2130147474 hasConceptScore W2130147474C55493867 @default.
• W2130147474 hasConceptScore W2130147474C86803240 @default.
• W2130147474 hasConceptScore W2130147474C89423630 @default.
• W2130147474 hasIssue "10" @default.
• W2130147474 hasLocation W21301474741 @default.
• W2130147474 hasLocation W21301474742 @default.
• W2130147474 hasLocation W21301474743 @default.
• W2130147474 hasOpenAccess W2130147474 @default.
• W2130147474 hasPrimaryLocation W21301474741 @default.
• W2130147474 hasRelatedWork W1965915652 @default.
• W2130147474 hasRelatedWork W2026224862 @default.
• W2130147474 hasRelatedWork W2043494161 @default.
• W2130147474 hasRelatedWork W2051284724 @default.
• W2130147474 hasRelatedWork W2053899751 @default.
• W2130147474 hasRelatedWork W2125018722 @default.
• W2130147474 hasRelatedWork W2130147474 @default.
• W2130147474 hasRelatedWork W2147227814 @default.
• W2130147474 hasRelatedWork W2166673478 @default.

• next