Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130167239> ?p ?o ?g. }
- W2130167239 endingPage "615" @default.
- W2130167239 startingPage "599" @default.
- W2130167239 abstract "Whether primary or secondary, lymphedema is caused by failure to drain protein-rich interstitial fluid. Typically affecting a whole limb, it has become apparent that lymphedema can also affect localized regions of the skin, or it can be clinically silent but histologically evident, denoted by dilated lymphangiectases (latent lymphedema). Chronic lymph stasis has numerous consequences, including lipogenesis, fibrosis, inflammation, lymphangiogenesis, and immunosuppression. For example, lymphedema’s disruption of immune cell trafficking leads to localized immune suppression, predisposing the area affected to chronic inflammation, infection (cellulitis and verrucosis), and malignancy (angiosarcoma and nonmelanoma skin cancer). The pathogenesis of lymphedema is reviewed and exemplified by describing how a combination of lymph stasis–promoting factors such as trauma, obesity, infection, and inflammatory disorders produces localized elephantiasis; furthermore, the finding of lymphangiectases is found to be common in numerous dermatologic disorders and argued to play a role in their pathogenesis. Lastly, it is discussed how antigen burden, which is controlled by lymphatic clearance, affects the immune response, resulting in immune tolerance, immunopathology, or normal adaptive immunity." @default.
- W2130167239 created "2016-06-24" @default.
- W2130167239 creator A5049483972 @default.
- W2130167239 date "2014-09-01" @default.
- W2130167239 modified "2023-09-25" @default.
- W2130167239 title "Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae" @default.
- W2130167239 cites W1964920262 @default.
- W2130167239 cites W1965003191 @default.
- W2130167239 cites W1968424323 @default.
- W2130167239 cites W1968699642 @default.
- W2130167239 cites W1969119156 @default.
- W2130167239 cites W1970084290 @default.
- W2130167239 cites W1970504446 @default.
- W2130167239 cites W1971053742 @default.
- W2130167239 cites W1973034565 @default.
- W2130167239 cites W1973489298 @default.
- W2130167239 cites W1973510541 @default.
- W2130167239 cites W1980035604 @default.
- W2130167239 cites W1981268098 @default.
- W2130167239 cites W1981444463 @default.
- W2130167239 cites W1982183902 @default.
- W2130167239 cites W1982667206 @default.
- W2130167239 cites W1983001235 @default.
- W2130167239 cites W1984437807 @default.
- W2130167239 cites W1986012088 @default.
- W2130167239 cites W1990489487 @default.
- W2130167239 cites W1991298929 @default.
- W2130167239 cites W1991949008 @default.
- W2130167239 cites W1992223994 @default.
- W2130167239 cites W1992398878 @default.
- W2130167239 cites W1994441890 @default.
- W2130167239 cites W1995139895 @default.
- W2130167239 cites W1996984198 @default.
- W2130167239 cites W1997944980 @default.
- W2130167239 cites W1999706720 @default.
- W2130167239 cites W2004292532 @default.
- W2130167239 cites W2004323419 @default.
- W2130167239 cites W2005278641 @default.
- W2130167239 cites W2005485699 @default.
- W2130167239 cites W2006986345 @default.
- W2130167239 cites W2009088668 @default.
- W2130167239 cites W2010820539 @default.
- W2130167239 cites W2010982978 @default.
- W2130167239 cites W2011673803 @default.
- W2130167239 cites W2012030196 @default.
- W2130167239 cites W2017390700 @default.
- W2130167239 cites W2019866094 @default.
- W2130167239 cites W2030553936 @default.
- W2130167239 cites W2032317077 @default.
- W2130167239 cites W2036662335 @default.
- W2130167239 cites W2039123261 @default.
- W2130167239 cites W2039375990 @default.
- W2130167239 cites W2041450316 @default.
- W2130167239 cites W2043221402 @default.
- W2130167239 cites W2045094761 @default.
- W2130167239 cites W2046948329 @default.
- W2130167239 cites W2047997627 @default.
- W2130167239 cites W2049250347 @default.
- W2130167239 cites W2058012303 @default.
- W2130167239 cites W2058483652 @default.
- W2130167239 cites W2058904163 @default.
- W2130167239 cites W2059487426 @default.
- W2130167239 cites W2059793973 @default.
- W2130167239 cites W2060952111 @default.
- W2130167239 cites W2069606069 @default.
- W2130167239 cites W2076139459 @default.
- W2130167239 cites W2080054224 @default.
- W2130167239 cites W2081440525 @default.
- W2130167239 cites W2081660598 @default.
- W2130167239 cites W2082034976 @default.
- W2130167239 cites W2084085941 @default.
- W2130167239 cites W2084431863 @default.
- W2130167239 cites W2090442910 @default.
- W2130167239 cites W2091720513 @default.
- W2130167239 cites W2093689484 @default.
- W2130167239 cites W2098350393 @default.
- W2130167239 cites W2098741046 @default.
- W2130167239 cites W2099135305 @default.
- W2130167239 cites W2099745901 @default.
- W2130167239 cites W2104367555 @default.
- W2130167239 cites W2105390673 @default.
- W2130167239 cites W2112334024 @default.
- W2130167239 cites W2114064598 @default.
- W2130167239 cites W2115462702 @default.
- W2130167239 cites W2119145971 @default.
- W2130167239 cites W2125799738 @default.
- W2130167239 cites W2126263193 @default.
- W2130167239 cites W2126372693 @default.
- W2130167239 cites W2133661892 @default.
- W2130167239 cites W2133770846 @default.
- W2130167239 cites W2136482853 @default.
- W2130167239 cites W2137564170 @default.
- W2130167239 cites W2138413317 @default.
- W2130167239 cites W2144204589 @default.
- W2130167239 cites W2147917703 @default.
- W2130167239 cites W2152117896 @default.
- W2130167239 cites W2154929223 @default.
- W2130167239 cites W2160928777 @default.