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• W2130173191 abstract "Our objective was to rigorously compare pinhole and parallel-hole collimation in an intrapatient, intrastudy design in 2 parathyroid imaging protocols: the first was dual-phase ^99mTc-sestamibi imaging, and the second was dual-phase ^99mTc-sestamibi plus dual-tracer (^99mTc-sestamibi and ¹²³I) simultaneous-acquisition subtraction imaging. <b>Methods:</b> Thirty-three patients with 37 surgically proven nonectopic parathyroid adenomas were evaluated. Anterior pinhole and parallel-hole images of the neck were available for ^99mTc-sestamibi at 15 min and 3 h, and for simultaneously acquired ^99mTc-sestamibi and ¹²³I subtraction at 15 min, all from a single study. The images were modified so that all had a square border and so that the thyroid filled approximately three quarters of the image. The images were evaluated by 2 experienced nuclear medicine physicians who did not know the surgical results or whether the images were acquired with pinhole or parallel-hole collimation. The observers indicated the location of any identified adenoma and graded the certainty of diagnosis on a 3-point scale. <b>Results:</b> The localization success rate for the 2 observers combined for the single-tracer dual-phase images was 66.2% with pinhole collimation and 43.2% with parallel-hole collimation (<i>P</i> < 0.0001). The localization success rate with the addition of the dual-tracer simultaneous-acquisition subtraction image was 83.8% with pinhole collimation and 62.2% with parallel-hole collimation (<i>P</i> = 0.0018). In addition, the degree of certainty of localization was greater with pinhole collimation with both imaging protocols (<i>P</i> < 0.001 in both cases). <b>Conclusion:</b> In the anterior projection, pinhole collimation is superior to parallel-hole collimation for parathyroid imaging with either dual-phase ^99mTc-sestamibi or dual-phase ^99mTc-sestamibi plus dual-tracer (^99mTc-sestamibi and ¹²³I) simultaneous-acquisition subtraction." @default.
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• W2130173191 date "2013-03-28" @default.
• W2130173191 modified "2023-10-16" @default.
• W2130173191 title "Parathyroid Imaging: The Importance of Pinhole Collimation with Both Single- and Dual-Tracer Acquisition" @default.
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• W2130173191 doi "https://doi.org/10.2967/jnmt.112.118208" @default.
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