Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130175905> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2130175905 endingPage "1275." @default.
- W2130175905 startingPage "1268" @default.
- W2130175905 abstract "This study determined the accuracy of previously defined adult fentanyl pharmacokinetics in children having surgery; from this population, the pharmacokinetics of fentanyl were characterized in children when administered via a computerized assisted continuous-infusion device.Twenty children between the ages of 2.7 and 11 y scheduled to undergo elective noncardiac surgery were studied. After induction, anesthesia was maintained with 60% nitrous oxide in oxygen supplemented with fentanyl (n = 10) or fentanyl plus isoflurane (n = 10). Fentanyl was administered via computerized assisted continuous-infusion to target concentrations determined by clinical requirements. Plasma fentanyl concentrations were measured and used to evaluate the performance of the fentanyl pharmacokinetics and then to determine a new set of pharmacokinetic parameters and the variance in the context-sensitive half-times simulated for these patients.The original adult fentanyl pharmacokinetics resulted in a positive bias (10.4%), indicating that measured concentrations were mostly greater than predicted. A two-compartment model with age and weight as covariates provided the optimal pharmacokinetic parameters. These resulted in a residual performance error of -1.1% and a median absolute performance error of 17.4%. The context-sensitive times determined from this pediatric population were considerably shorter than the context-sensitive times previously published for adults.The pharmacokinetics of fentanyl administered by computerized assisted continuous-infusion differ between adults and children. The newly derived parameters are probably more suitable to determine infusion schemes of up to 4 h in children between the ages of 2 and 11 y." @default.
- W2130175905 created "2016-06-24" @default.
- W2130175905 creator A5003010239 @default.
- W2130175905 creator A5007039466 @default.
- W2130175905 creator A5018002011 @default.
- W2130175905 creator A5046354506 @default.
- W2130175905 creator A5060070507 @default.
- W2130175905 creator A5076462126 @default.
- W2130175905 creator A5086221714 @default.
- W2130175905 date "1996-12-01" @default.
- W2130175905 modified "2023-10-11" @default.
- W2130175905 title "Pharmacokinetic Model-driven Infusion of Fentanyl in Children" @default.
- W2130175905 cites W1978967575 @default.
- W2130175905 cites W2031428717 @default.
- W2130175905 cites W2034572193 @default.
- W2130175905 cites W2040394464 @default.
- W2130175905 cites W2049622757 @default.
- W2130175905 cites W2062921250 @default.
- W2130175905 cites W2066996342 @default.
- W2130175905 cites W2068155122 @default.
- W2130175905 cites W2078414113 @default.
- W2130175905 cites W2088267315 @default.
- W2130175905 cites W2093584216 @default.
- W2130175905 cites W2106727887 @default.
- W2130175905 cites W2114588857 @default.
- W2130175905 cites W2153049571 @default.
- W2130175905 cites W2158050681 @default.
- W2130175905 doi "https://doi.org/10.1097/00000542-199612000-00007" @default.
- W2130175905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8968173" @default.
- W2130175905 hasPublicationYear "1996" @default.
- W2130175905 type Work @default.
- W2130175905 sameAs 2130175905 @default.
- W2130175905 citedByCount "47" @default.
- W2130175905 countsByYear W21301759052012 @default.
- W2130175905 countsByYear W21301759052013 @default.
- W2130175905 countsByYear W21301759052014 @default.
- W2130175905 countsByYear W21301759052015 @default.
- W2130175905 countsByYear W21301759052016 @default.
- W2130175905 countsByYear W21301759052017 @default.
- W2130175905 countsByYear W21301759052018 @default.
- W2130175905 countsByYear W21301759052019 @default.
- W2130175905 countsByYear W21301759052020 @default.
- W2130175905 countsByYear W21301759052021 @default.
- W2130175905 countsByYear W21301759052023 @default.
- W2130175905 crossrefType "journal-article" @default.
- W2130175905 hasAuthorship W2130175905A5003010239 @default.
- W2130175905 hasAuthorship W2130175905A5007039466 @default.
- W2130175905 hasAuthorship W2130175905A5018002011 @default.
- W2130175905 hasAuthorship W2130175905A5046354506 @default.
- W2130175905 hasAuthorship W2130175905A5060070507 @default.
- W2130175905 hasAuthorship W2130175905A5076462126 @default.
- W2130175905 hasAuthorship W2130175905A5086221714 @default.
- W2130175905 hasBestOaLocation W21301759051 @default.
- W2130175905 hasConcept C112705442 @default.
- W2130175905 hasConcept C151730666 @default.
- W2130175905 hasConcept C2776359302 @default.
- W2130175905 hasConcept C2779343474 @default.
- W2130175905 hasConcept C2781072394 @default.
- W2130175905 hasConcept C2908647359 @default.
- W2130175905 hasConcept C3020755252 @default.
- W2130175905 hasConcept C42219234 @default.
- W2130175905 hasConcept C71924100 @default.
- W2130175905 hasConcept C86803240 @default.
- W2130175905 hasConcept C98274493 @default.
- W2130175905 hasConcept C99454951 @default.
- W2130175905 hasConceptScore W2130175905C112705442 @default.
- W2130175905 hasConceptScore W2130175905C151730666 @default.
- W2130175905 hasConceptScore W2130175905C2776359302 @default.
- W2130175905 hasConceptScore W2130175905C2779343474 @default.
- W2130175905 hasConceptScore W2130175905C2781072394 @default.
- W2130175905 hasConceptScore W2130175905C2908647359 @default.
- W2130175905 hasConceptScore W2130175905C3020755252 @default.
- W2130175905 hasConceptScore W2130175905C42219234 @default.
- W2130175905 hasConceptScore W2130175905C71924100 @default.
- W2130175905 hasConceptScore W2130175905C86803240 @default.
- W2130175905 hasConceptScore W2130175905C98274493 @default.
- W2130175905 hasConceptScore W2130175905C99454951 @default.
- W2130175905 hasIssue "6" @default.
- W2130175905 hasLocation W21301759051 @default.
- W2130175905 hasLocation W21301759052 @default.
- W2130175905 hasOpenAccess W2130175905 @default.
- W2130175905 hasPrimaryLocation W21301759051 @default.
- W2130175905 hasRelatedWork W2012245195 @default.
- W2130175905 hasRelatedWork W2023626529 @default.
- W2130175905 hasRelatedWork W2032097219 @default.
- W2130175905 hasRelatedWork W2038428025 @default.
- W2130175905 hasRelatedWork W2090130059 @default.
- W2130175905 hasRelatedWork W2148097904 @default.
- W2130175905 hasRelatedWork W2347911360 @default.
- W2130175905 hasRelatedWork W2367927558 @default.
- W2130175905 hasRelatedWork W2474101975 @default.
- W2130175905 hasRelatedWork W56975623 @default.
- W2130175905 hasVolume "85" @default.
- W2130175905 isParatext "false" @default.
- W2130175905 isRetracted "false" @default.
- W2130175905 magId "2130175905" @default.
- W2130175905 workType "article" @default.