Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130183902> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2130183902 endingPage "390" @default.
- W2130183902 startingPage "384" @default.
- W2130183902 abstract "Background: There are currently limited data on whether the effect of spironolactone in patients with resistant arterial hypertension depends on age and sex. Methods: Patients with an office systolic blood pressure (BP) >140 mmHg or diastolic BP >90 mmHg, despite treatment with at least 3 antihypertensive drugs including a diuretic, were randomly assigned to receive spironolactone or a placebo for 8 weeks in a double-blind, placebo-controlled, multicentre trial (ASPIRANT). Results: Analyses were done on 55 patients treated with spironolactone and 56 patients treated with placebo. Significant reductions of office systolic BP (-8.9 ± 6.7 mmHg, P=0.012), 24-h ABPM systolic BP (-7.9 ± 7.2 mmHg, P=0.032) and ABPM day-time systolic BP (-7.5 ± 7.1 mmHg) after 8 weeks of spironolactone treatment, compared to placebo, were only observed in patients with a median age >62 years. The office and ABPM systolic BP reductions in patients aged ≤62 years and diastolic BP reductions by spironolactone in both age groups were not significant compared to placebo. Women tended to have a nonsignificantly higher reduction in systolic BP with spironolactone treatment, and there was no difference in diastolic BP reduction between women and men. Conclusions: Spironolactone only leads to a reduction of systolic BP in older patients with resistant arterial hypertension aged >62 years, and is effective to a similar extent in men and women." @default.
- W2130183902 created "2016-06-24" @default.
- W2130183902 creator A5032060686 @default.
- W2130183902 creator A5047238963 @default.
- W2130183902 creator A5051567265 @default.
- W2130183902 creator A5072939562 @default.
- W2130183902 creator A5083791579 @default.
- W2130183902 date "2014-09-30" @default.
- W2130183902 modified "2023-10-18" @default.
- W2130183902 title "Effect of spironolactone in patients with resistant arterial hypertension in relation to age and sex: Insights from the aspirant trial" @default.
- W2130183902 cites W1987919111 @default.
- W2130183902 cites W2007001442 @default.
- W2130183902 cites W2007947774 @default.
- W2130183902 cites W2018629716 @default.
- W2130183902 cites W2023340577 @default.
- W2130183902 cites W2039340766 @default.
- W2130183902 cites W2041502303 @default.
- W2130183902 cites W2057641383 @default.
- W2130183902 cites W2064532153 @default.
- W2130183902 cites W2089682547 @default.
- W2130183902 cites W2102036895 @default.
- W2130183902 cites W2122915712 @default.
- W2130183902 cites W2123540409 @default.
- W2130183902 cites W2134052088 @default.
- W2130183902 cites W2135100154 @default.
- W2130183902 cites W2146282879 @default.
- W2130183902 cites W2150734413 @default.
- W2130183902 cites W2152594920 @default.
- W2130183902 cites W2172086404 @default.
- W2130183902 cites W2936597036 @default.
- W2130183902 cites W4231340514 @default.
- W2130183902 doi "https://doi.org/10.5507/bp.2012.105" @default.
- W2130183902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23235719" @default.
- W2130183902 hasPublicationYear "2014" @default.
- W2130183902 type Work @default.
- W2130183902 sameAs 2130183902 @default.
- W2130183902 citedByCount "4" @default.
- W2130183902 countsByYear W21301839022014 @default.
- W2130183902 countsByYear W21301839022019 @default.
- W2130183902 countsByYear W21301839022020 @default.
- W2130183902 crossrefType "journal-article" @default.
- W2130183902 hasAuthorship W2130183902A5032060686 @default.
- W2130183902 hasAuthorship W2130183902A5047238963 @default.
- W2130183902 hasAuthorship W2130183902A5051567265 @default.
- W2130183902 hasAuthorship W2130183902A5072939562 @default.
- W2130183902 hasAuthorship W2130183902A5083791579 @default.
- W2130183902 hasBestOaLocation W21301839021 @default.
- W2130183902 hasConcept C126322002 @default.
- W2130183902 hasConcept C142724271 @default.
- W2130183902 hasConcept C164705383 @default.
- W2130183902 hasConcept C204787440 @default.
- W2130183902 hasConcept C27081682 @default.
- W2130183902 hasConcept C2776379505 @default.
- W2130183902 hasConcept C2777193177 @default.
- W2130183902 hasConcept C2778198053 @default.
- W2130183902 hasConcept C2779918671 @default.
- W2130183902 hasConcept C57900726 @default.
- W2130183902 hasConcept C71924100 @default.
- W2130183902 hasConcept C84393581 @default.
- W2130183902 hasConceptScore W2130183902C126322002 @default.
- W2130183902 hasConceptScore W2130183902C142724271 @default.
- W2130183902 hasConceptScore W2130183902C164705383 @default.
- W2130183902 hasConceptScore W2130183902C204787440 @default.
- W2130183902 hasConceptScore W2130183902C27081682 @default.
- W2130183902 hasConceptScore W2130183902C2776379505 @default.
- W2130183902 hasConceptScore W2130183902C2777193177 @default.
- W2130183902 hasConceptScore W2130183902C2778198053 @default.
- W2130183902 hasConceptScore W2130183902C2779918671 @default.
- W2130183902 hasConceptScore W2130183902C57900726 @default.
- W2130183902 hasConceptScore W2130183902C71924100 @default.
- W2130183902 hasConceptScore W2130183902C84393581 @default.
- W2130183902 hasIssue "3" @default.
- W2130183902 hasLocation W21301839021 @default.
- W2130183902 hasLocation W21301839022 @default.
- W2130183902 hasOpenAccess W2130183902 @default.
- W2130183902 hasPrimaryLocation W21301839021 @default.
- W2130183902 hasRelatedWork W1797367453 @default.
- W2130183902 hasRelatedWork W2065130933 @default.
- W2130183902 hasRelatedWork W2073502284 @default.
- W2130183902 hasRelatedWork W2084999170 @default.
- W2130183902 hasRelatedWork W2135427367 @default.
- W2130183902 hasRelatedWork W2150734413 @default.
- W2130183902 hasRelatedWork W2161975266 @default.
- W2130183902 hasRelatedWork W2365320204 @default.
- W2130183902 hasRelatedWork W2586119386 @default.
- W2130183902 hasRelatedWork W4297491966 @default.
- W2130183902 hasVolume "158" @default.
- W2130183902 isParatext "false" @default.
- W2130183902 isRetracted "false" @default.
- W2130183902 magId "2130183902" @default.
- W2130183902 workType "article" @default.