FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130183973> ?p ?o ?g. }

• W2130183973 endingPage "217" @default.
• W2130183973 startingPage "210" @default.
• W2130183973 abstract "The effect of biliary diversion on intestinal apolipoprotein (apoA)-I and high density lipoprotein formation was studied in mesenteric lymph fistula rats. Bile diversion was produced by an exteriorized catheter that allowed interruption and reconstitution of the enterohepatic circulation. Bile diversion reduced lymph cholesterol output from 0.47±0.05 μmol/h to 0.17±0.03 μmol/h (P < 0.025), and lymph triglyceride output from 3.6±0.3μmol/h to 0.6±0.05 μmol/h (P < 0.025) after 24 h. This was due to depletion of lymph chylomicrons and very low density lipoprotein (VLDL). Despite the reduced lipid outputs, lymph apoA-I output was maintained during biliary diversion (basal: 119±15 μg/h; diverted 140±20 μg/h, n = 12). During biliary diversion, high density lipoprotein (HDL) were maintained in mesenteric lymph as shown by lipoprotein and immunoelectrophoresis. Bile diversion altered the lipid composition of lymph HDL. Bile-diverted lymph HDL was depleted in total cholesterol and has a greater phospholipid/cholesterol ester ratio than basal lymph HDL. Lymph HDL contained discoidal particles when examined by negative stain electron microscopy. Bile diversion was associated with a reduction in the size of discoidal HDL particles (basal, nondiverted, 165±7Å (n = 112) compared with diverted 126±5Å (n = 98, P < 0.025). Experiments were then carried out to determine the source of the apoA-I and HDL found in lymph from bile-diverted animals. The transfer of HDL from plasma into lymph was determined by the intravenous infusion of 125I-apoA-I labeled HDL into lymph fistula rats. In both nonbile-diverted and diverted rats, the specific activity of apoA-I in the HDL fraction of lymph was 23% of the specific activity of apoA-I in plasma HDL, indicating that the major portion (75%) of mesenteric lymph apoA-I did not come from plasma filtration. In other experiments the intraduodenal infusion of [3H]leucine to bile fistula, lymph fistula rats resulted in relative fivefold increase in the specific activity in apoA-I in lymph HDL when compared with the specific activity of apoA-I in plasma HDL from the same animal. We conclude that intestinal apoA-I secretion is maintained during biliary diversion and that synthesis of this apoprotein occurs in the absence of chylomicron formation. We also conclude that discoidal HDL are present in mesenteric lymph despite reduced triglyceride absorption and secretion into lymph." @default.
• W2130183973 created "2016-06-24" @default.
• W2130183973 creator A5005512235 @default.
• W2130183973 creator A5017054878 @default.
• W2130183973 creator A5018642661 @default.
• W2130183973 creator A5064157681 @default.
• W2130183973 creator A5085786647 @default.
• W2130183973 date "1982-01-01" @default.
• W2130183973 modified "2023-09-26" @default.
• W2130183973 title "Effect of Biliary Diversion on Rat Mesenteric Lymph Apolipoprotein-I and High Density Lipoprotein" @default.
• W2130183973 cites W1548991782 @default.
• W2130183973 cites W1629280082 @default.
• W2130183973 cites W1775749144 @default.
• W2130183973 cites W1877977152 @default.
• W2130183973 cites W1973399704 @default.
• W2130183973 cites W1980317475 @default.
• W2130183973 cites W1980644324 @default.
• W2130183973 cites W1990986783 @default.
• W2130183973 cites W1995840194 @default.
• W2130183973 cites W2005384461 @default.
• W2130183973 cites W2013264428 @default.
• W2130183973 cites W2021985116 @default.
• W2130183973 cites W2022863823 @default.
• W2130183973 cites W2073879684 @default.
• W2130183973 cites W2087295650 @default.
• W2130183973 cites W2101584400 @default.
• W2130183973 cites W2104665313 @default.
• W2130183973 cites W2113006405 @default.
• W2130183973 cites W2156262445 @default.
• W2130183973 cites W2158210244 @default.
• W2130183973 cites W2168224634 @default.
• W2130183973 cites W2168526937 @default.
• W2130183973 cites W2249523505 @default.
• W2130183973 cites W2346779575 @default.
• W2130183973 cites W2398870494 @default.
• W2130183973 cites W2412274443 @default.
• W2130183973 doi "https://doi.org/10.1172/jci110432" @default.
• W2130183973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/371184" @default.
• W2130183973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6798073" @default.
• W2130183973 hasPublicationYear "1982" @default.
• W2130183973 type Work @default.
• W2130183973 sameAs 2130183973 @default.
• W2130183973 citedByCount "47" @default.
• W2130183973 countsByYear W21301839732012 @default.
• W2130183973 countsByYear W21301839732013 @default.
• W2130183973 countsByYear W21301839732014 @default.
• W2130183973 countsByYear W21301839732015 @default.
• W2130183973 countsByYear W21301839732020 @default.
• W2130183973 countsByYear W21301839732021 @default.
• W2130183973 crossrefType "journal-article" @default.
• W2130183973 hasAuthorship W2130183973A5005512235 @default.
• W2130183973 hasAuthorship W2130183973A5017054878 @default.
• W2130183973 hasAuthorship W2130183973A5018642661 @default.
• W2130183973 hasAuthorship W2130183973A5064157681 @default.
• W2130183973 hasAuthorship W2130183973A5085786647 @default.
• W2130183973 hasBestOaLocation W21301839731 @default.
• W2130183973 hasConcept C11772777 @default.
• W2130183973 hasConcept C126322002 @default.
• W2130183973 hasConcept C134018914 @default.
• W2130183973 hasConcept C142724271 @default.
• W2130183973 hasConcept C185592680 @default.
• W2130183973 hasConcept C2778163477 @default.
• W2130183973 hasConcept C2779720271 @default.
• W2130183973 hasConcept C2780072125 @default.
• W2130183973 hasConcept C2780541478 @default.
• W2130183973 hasConcept C62746215 @default.
• W2130183973 hasConcept C71924100 @default.
• W2130183973 hasConcept C8243546 @default.
• W2130183973 hasConceptScore W2130183973C11772777 @default.
• W2130183973 hasConceptScore W2130183973C126322002 @default.
• W2130183973 hasConceptScore W2130183973C134018914 @default.
• W2130183973 hasConceptScore W2130183973C142724271 @default.
• W2130183973 hasConceptScore W2130183973C185592680 @default.
• W2130183973 hasConceptScore W2130183973C2778163477 @default.
• W2130183973 hasConceptScore W2130183973C2779720271 @default.
• W2130183973 hasConceptScore W2130183973C2780072125 @default.
• W2130183973 hasConceptScore W2130183973C2780541478 @default.
• W2130183973 hasConceptScore W2130183973C62746215 @default.
• W2130183973 hasConceptScore W2130183973C71924100 @default.
• W2130183973 hasConceptScore W2130183973C8243546 @default.
• W2130183973 hasIssue "1" @default.
• W2130183973 hasLocation W21301839731 @default.
• W2130183973 hasLocation W21301839732 @default.
• W2130183973 hasLocation W21301839733 @default.
• W2130183973 hasLocation W21301839734 @default.
• W2130183973 hasOpenAccess W2130183973 @default.
• W2130183973 hasPrimaryLocation W21301839731 @default.
• W2130183973 hasRelatedWork W1938181543 @default.
• W2130183973 hasRelatedWork W1963969818 @default.
• W2130183973 hasRelatedWork W1976602105 @default.
• W2130183973 hasRelatedWork W2025648868 @default.
• W2130183973 hasRelatedWork W2117255531 @default.
• W2130183973 hasRelatedWork W2149619505 @default.
• W2130183973 hasRelatedWork W2157000830 @default.
• W2130183973 hasRelatedWork W2284236454 @default.
• W2130183973 hasRelatedWork W2402474876 @default.
• W2130183973 hasRelatedWork W2413861530 @default.
• W2130183973 hasVolume "69" @default.

• next