Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130193858> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2130193858 endingPage "272" @default.
- W2130193858 startingPage "266" @default.
- W2130193858 abstract "Alpha glutathione S-transferase (alpha-GST) has been shown to be an immunohistochemical marker for delta(4-5) isomerase, an enzyme active in steroidogenesis. The purpose of this study was to document the distribution of alpha-GST in ovarian neoplasms in order to evaluate its usefulness as a diagnostic tool.A total of 92 tumours (25 sex cord/stromal, 53 epithelial and 14 germ cell) were subjected to immunohistochemistry using a commercially available polyclonal antibody to alpha-GST. The avidin-biotin complex was used as a detection system. Positive staining was found in luteinized stromal cells of all tumour types (58/92). This included the Leydig cells of Sertoli-Leydig cell tumours (7/7) and was particularly prominent in the stromal cells of both benign and malignant mucinous tumours (24/25). Granulosa and Sertoli cells showed weak or no intracytoplasmic staining, which is expected because they do not normally produce androstenedione. They did show some intranuclear staining. Malignant mucinous (12/25) and occasional other epithelial tumours showed focal intracytoplasmic positive staining. Yolk sac tumours showed focal positivity (7/8).Intracytoplasmic staining of stromal cells is considered to indicate steroidogenesis and intranuclear staining the intracytoplasmic transport function of alpha-GST. The intracytoplasmic staining of mucinous carcinomas might represent an up-regulation of some detoxification function. The findings suggest that antibody to alpha-GST has some value in the investigation of ovarian pathology and could readily be included in any panel of antibodies used to investigate ovarian neoplasms of uncertain histogenesis." @default.
- W2130193858 created "2016-06-24" @default.
- W2130193858 creator A5020182034 @default.
- W2130193858 creator A5042261377 @default.
- W2130193858 date "2001-09-01" @default.
- W2130193858 modified "2023-10-18" @default.
- W2130193858 title "Distribution of alpha glutathione S-transferase in ovarian neoplasms: an immunohistochemical study" @default.
- W2130193858 cites W1493036774 @default.
- W2130193858 cites W1582750215 @default.
- W2130193858 cites W1966798136 @default.
- W2130193858 cites W1972333756 @default.
- W2130193858 cites W1978957756 @default.
- W2130193858 cites W1990430463 @default.
- W2130193858 cites W2010131959 @default.
- W2130193858 cites W2012676404 @default.
- W2130193858 cites W2015685869 @default.
- W2130193858 cites W2021303955 @default.
- W2130193858 cites W2021982300 @default.
- W2130193858 cites W2058838832 @default.
- W2130193858 cites W2060477903 @default.
- W2130193858 cites W2070998929 @default.
- W2130193858 cites W2090340820 @default.
- W2130193858 cites W2094836511 @default.
- W2130193858 cites W2108266588 @default.
- W2130193858 cites W4245957869 @default.
- W2130193858 doi "https://doi.org/10.1046/j.1365-2559.2001.01202.x" @default.
- W2130193858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532037" @default.
- W2130193858 hasPublicationYear "2001" @default.
- W2130193858 type Work @default.
- W2130193858 sameAs 2130193858 @default.
- W2130193858 citedByCount "9" @default.
- W2130193858 countsByYear W21301938582018 @default.
- W2130193858 crossrefType "journal-article" @default.
- W2130193858 hasAuthorship W2130193858A5020182034 @default.
- W2130193858 hasAuthorship W2130193858A5042261377 @default.
- W2130193858 hasConcept C134018914 @default.
- W2130193858 hasConcept C142724271 @default.
- W2130193858 hasConcept C16930146 @default.
- W2130193858 hasConcept C191548132 @default.
- W2130193858 hasConcept C203014093 @default.
- W2130193858 hasConcept C204232928 @default.
- W2130193858 hasConcept C2778324911 @default.
- W2130193858 hasConcept C502942594 @default.
- W2130193858 hasConcept C71924100 @default.
- W2130193858 hasConcept C74864618 @default.
- W2130193858 hasConcept C86803240 @default.
- W2130193858 hasConceptScore W2130193858C134018914 @default.
- W2130193858 hasConceptScore W2130193858C142724271 @default.
- W2130193858 hasConceptScore W2130193858C16930146 @default.
- W2130193858 hasConceptScore W2130193858C191548132 @default.
- W2130193858 hasConceptScore W2130193858C203014093 @default.
- W2130193858 hasConceptScore W2130193858C204232928 @default.
- W2130193858 hasConceptScore W2130193858C2778324911 @default.
- W2130193858 hasConceptScore W2130193858C502942594 @default.
- W2130193858 hasConceptScore W2130193858C71924100 @default.
- W2130193858 hasConceptScore W2130193858C74864618 @default.
- W2130193858 hasConceptScore W2130193858C86803240 @default.
- W2130193858 hasIssue "3" @default.
- W2130193858 hasLocation W21301938581 @default.
- W2130193858 hasLocation W21301938582 @default.
- W2130193858 hasOpenAccess W2130193858 @default.
- W2130193858 hasPrimaryLocation W21301938581 @default.
- W2130193858 hasRelatedWork W1964088419 @default.
- W2130193858 hasRelatedWork W2021604310 @default.
- W2130193858 hasRelatedWork W2155716040 @default.
- W2130193858 hasRelatedWork W2283345642 @default.
- W2130193858 hasRelatedWork W2376941458 @default.
- W2130193858 hasRelatedWork W2396181149 @default.
- W2130193858 hasRelatedWork W2410097877 @default.
- W2130193858 hasRelatedWork W2462644324 @default.
- W2130193858 hasRelatedWork W2992410134 @default.
- W2130193858 hasRelatedWork W4290163925 @default.
- W2130193858 hasVolume "39" @default.
- W2130193858 isParatext "false" @default.
- W2130193858 isRetracted "false" @default.
- W2130193858 magId "2130193858" @default.
- W2130193858 workType "article" @default.