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• W2130201220 abstract "Abstract T cell adoptive transfer strategies that have produced clinical remissions against specific tumors have so far produced disappointing results against ovarian cancer. Recent evidence suggests that adoptively transferred CD4+ T cells can trigger endogenous immune responses in particular patients with ovarian cancer through unknown mechanisms. However, conflicting reports suggest that ovarian cancer-infiltrating CD4+ T cells are associated with negative outcomes. In this study, we elucidate the phenotypic attributes that enable polyclonal CD4+ T cells briefly primed against tumor Ags to induce therapeutically relevant endogenous antitumor immune responses. Our results unveil a therapeutic mechanism whereby tumor-primed CD4+ T cells transferred into ovarian cancer-bearing mice secrete high levels of CCL5, which recruits endogenous CCR5+ dendritic cells to tumor locations and activate them through CD40–CD40L interactions. These newly matured dendritic cells are then able to prime tumor-specific endogenous CD8+ T cells, which mediate long-term protection. Correspondingly, administration of tumor-primed CD4+ T cells significantly delayed progression of MHC class II− ovarian cancers, similarly to CD8+ T cells only, and directly activated wild-type but not CD40-deficient dendritic cells recruited to the tumor microenvironment. Our results unveil a CCL5- and CD40L-dependent mechanism of transferring immunity from exogenously activated CD4+ T cells to tumor-exposed host cells, resulting in sustained antitumor effects. Our data provide a mechanistic rationale for incorporating tumor-reactive CD4+ T cells in adoptive cell transfer immunotherapies against ovarian cancer and underscore the importance of optimizing immunotherapeutic strategies for the specific microenvironment of individual tumors." @default.
• W2130201220 created "2016-06-24" @default.
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• W2130201220 date "2010-05-15" @default.
• W2130201220 modified "2023-09-23" @default.
• W2130201220 title "CD4+ T Cells Elicit Host Immune Responses to MHC Class II− Ovarian Cancer through CCL5 Secretion and CD40-Mediated Licensing of Dendritic Cells" @default.
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• W2130201220 doi "https://doi.org/10.4049/jimmunol.0903247" @default.
• W2130201220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2874073" @default.
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