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• W2130202391 abstract "The immunogenicity and protective efficacy of a DNA and recombinant modified vaccinia Ankara (MVA) vaccine administered by two different routes were investigated. DNA expressing HIV-1 IIIB env , gag , RT , rev , tat and nef , and MVA expressing HIV-1 IIIB nef , tat and rev and simian immunodeficiency virus (SIV) macJ5 gag / pol and vaccinia HIV-1 env , were used as immunogens. Four cynomolgus macaques received DNA intramuscularly (i.m.) at month 0 and intrarectally (i.r.) and intra-orally (i.o.) at 2 months, followed by MVA i.m. at 4 months and i.r. and i.o. at 8 months. Another group of four monkeys received the same immunogens but only i.m.. Overall, stronger cellular immune responses measured by ELISPOT and T-cell proliferation assay were detected in the group primed i.m. and boosted mucosally. Following homologous intravenous simian-human immunodeficiency virus (SHIV) challenge, one of eight vaccinated animals was completely protected. This monkey, immunized i.m. and i.r.+i.o., exhibited the highest levels of HIV Env, Nef and Tat antibodies, high HIV Tat cytotoxic T-lymphocyte activity and T-lymphocyte proliferative responses to HIV Env. Four weeks post-challenge none of the monkeys immunized i.m. and i.r.+i.o., and only two out of four animals immunized i.m., demonstrated detectable plasma viral RNA levels. In contrast, all eight control animals had demonstrable plasma viral RNA levels 4 weeks post-challenge. Thus, stronger cellular immune responses and reduction of challenge virus burden were demonstrated in animals immunized i.m. as well as mucosally, compared with animals immunized i.m. only. The breadth and magnitude of the induced immune responses correlated with protective efficacy." @default.
• W2130202391 created "2016-06-24" @default.
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• W2130202391 date "2004-08-01" @default.
• W2130202391 modified "2023-10-03" @default.
• W2130202391 title "Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen" @default.
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• W2130202391 cites W1655510925 @default.
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• W2130202391 cites W1826616136 @default.
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• W2130202391 cites W1971998789 @default.
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• W2130202391 cites W1996564095 @default.
• W2130202391 cites W1996893919 @default.
• W2130202391 cites W2001974402 @default.
• W2130202391 cites W2002301242 @default.
• W2130202391 cites W2002657509 @default.
• W2130202391 cites W2012139740 @default.
• W2130202391 cites W2023839606 @default.
• W2130202391 cites W2028609919 @default.
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• W2130202391 cites W2054453753 @default.
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• W2130202391 cites W2059551093 @default.
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• W2130202391 doi "https://doi.org/10.1099/vir.0.79869-0" @default.
• W2130202391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15269383" @default.
• W2130202391 hasPublicationYear "2004" @default.
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