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• W2130202913 endingPage "181" @default.
• W2130202913 startingPage "173" @default.
• W2130202913 abstract "Adenosine is a signaling nucleoside that is produced following tissue injury, particularly injury involving ischemia and hypoxia. The production of extracellular adenosine and its subsequent signaling through adenosine receptors plays an important role in orchestrating injury responses in multiple organs. There are four adenosine receptors that are widely distributed on immune, epithelial, endothelial, neuronal,and stromal cells throughout the body. Interestingly, these receptors are subject to altered regulation following injury. Studies in mouse models and human cells and tissues have identified that the production of adenosine and its subsequent signaling through its receptors plays largely beneficial roles in acute disease states, with the exception of brain injury. In contrast, if elevated adenosine levels are sustained beyond the acute injury phase, adenosine responses can become detrimental by activating pathways that promote tissue injury and fibrosis. Understanding when during the course of disease adenosine signaling is beneficial as opposed to detrimental and defining the mechanisms involved will be critical for the advancement of adenosine-based therapies for acute and chronic diseases. The purpose of this review is to discuss key observations that define the beneficial and detrimental aspects of adenosine signaling during acute and chronic disease states with an emphasis on cellular processes, such as inflammatory cell regulation, vascular barrier function, and tissue fibrosis." @default.
• W2130202913 created "2016-06-24" @default.
• W2130202913 creator A5009800945 @default.
• W2130202913 creator A5058022497 @default.
• W2130202913 creator A5070127090 @default.
• W2130202913 date "2013-01-23" @default.
• W2130202913 modified "2023-09-30" @default.
• W2130202913 title "Adenosine signaling during acute and chronic disease states" @default.
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