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- W2130207165 abstract "The mechanisms responsible for initiating autoimmune diabetes remain obscure. Here, we describe a method for identifying both the alpha- and beta-chains of the T cell receptor (TCR) from individual pancreatic islet-infiltrating T cells at the earliest stages of disease in nonobese diabetic mice (NOD). Analysis of the TCR repertoire of these early islet infiltrates reveals enrichment for a small subset of TCR sequences. Reconstitution of these TCR in vitro demonstrates that these receptors confer reactivity to islet cells but not to the well characterized autoantigens, glutamic acid decarboxylase (GAD65) and insulin. Thus, autoimmune diabetes in NOD may be initiated by a limited number of antigens distinct from GAD65 and insulin." @default.
- W2130207165 created "2016-06-24" @default.
- W2130207165 creator A5010249092 @default.
- W2130207165 creator A5043075758 @default.
- W2130207165 creator A5082316006 @default.
- W2130207165 creator A5084421962 @default.
- W2130207165 date "2002-06-24" @default.
- W2130207165 modified "2023-10-15" @default.
- W2130207165 title "Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice" @default.
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- W2130207165 doi "https://doi.org/10.1073/pnas.142284899" @default.
- W2130207165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/123148" @default.
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