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- W2130223825 abstract "A distinctive and geographically widespread category of low-activity variant at the Gpdh locus in Drosophila melanogaster is shown to have defective P elements inserted between the TATA box and the transcription start site. In four examples the insertion was a single 1.15 kilobase (kb) KP element, whereas in another variant there were two KP elements in tandem. A sixth example contained a 0.61 kb defective P element. The target site for all of the insertions is GTGCAAAC. There was no sequence variation either between the insertions or in comparison with two other KP elements previously described from natural populations. The insertions cause a reduction in GPDH mRNA, and are the most likely cause of the low GPDH activity." @default.
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- W2130223825 date "1993-01-22" @default.
- W2130223825 modified "2023-09-24" @default.
- W2130223825 title "Defective P element insertions affect the expression ofsn-glycerol-3-phosphate dehydrogenase alleles in natural populations ofDrosophila melanogaster" @default.
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- W2130223825 doi "https://doi.org/10.1098/rspb.1993.0006" @default.
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