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- W2130247488 abstract "Abstract Background Interstitial lung diseases (ILD) are chronic inflammatory disorders leading to pulmonary fibrosis. Monocyte chemotactic protein 1 (MCP-1) promotes collagen synthesis and deletion of the MCP-1 receptor CCR2 protects from pulmonary fibrosis in ILD mouse models. We hypothesized that pulmonary MCP-1 and CCR2 + T cells accumulate in pediatric ILD and are related to disease severity. Methods Bronchoalveolar lavage fluid was obtained from 25 children with ILD and 10 healthy children. Levels of pulmonary MCP-1 and Th1/Th2-associated cytokines were quantified at the protein and the mRNA levels. Pulmonary CCR2 + , CCR4 + , CCR3 + , CCR5 + and CXCR3 + T cells were quantified by flow-cytometry. Results CCR2 + T cells and MCP-1 levels were significantly elevated in children with ILD and correlated with forced vital capacity, total lung capacity and ILD disease severity scores. Children with lung fibrosis had significantly higher MCP-1 levels and CCR2 + T cells in bronchoalveolar lavage fluid compared to non-fibrotic children. Conclusion The results indicate that pulmonary CCR2 + T cells and MCP-1 contribute to the pathogenesis of pediatric ILD and might provide a novel target for therapeutic strategies." @default.
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- W2130247488 date "2005-08-11" @default.
- W2130247488 modified "2023-10-15" @default.
- W2130247488 title "A role for MCP-1/CCR2 in interstitial lung disease in children" @default.
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- W2130247488 doi "https://doi.org/10.1186/1465-9921-6-93" @default.
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