FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130251213> ?p ?o ?g. }

• W2130251213 endingPage "708" @default.
• W2130251213 startingPage "704" @default.
• W2130251213 abstract "Women with primary breast cancer who receive systemic therapy may experience ovarian failure or early menopause, leading to a loss of bone mineral density (BMD). Loss of BMD may be reduced by use of bisphosphonates, compounds that inhibit the action of osteoclasts (cells that absorb or remove bone tissue). We have conducted a double-blind, randomized, two-center trial to evaluate BMD in women with primary breast cancer who were given the bisphosphonate clodronate (1600 mg/day orally) or placebo for 2 years.From August 31, 1990, through March 31, 1996, more than 300 eligible patients had been accrued, randomly assigned to study treatment, given the appropriate primary surgical care and systemic (chemotherapy and/or tamoxifen) therapy, and had completed follow-up for at least 1 year. BMD in the lumbar spine and in the hip, including the trochanteric area, was measured by use of dual-energy x-ray absorptiometry at the beginning of treatment and after 1 and 2 years of treatment. Changes in BMD were calculated as percent changes from the initial readings. Treatment effects for clodronate versus placebo (i.e., mean percent changes in BMD with clodronate minus mean percent changes in BMD with placebo) at 1 and 2 years for individual sites were calculated.After 1 year, the treatment effects for clodronate versus placebo in the lumbar spine, the total hip, and the trochanter, respectively, were as follows: +2.38% (95% confidence interval [CI] = 1.36-3.41), +0.74% (95% CI = -0.13 - 1.60), and +1.29% (95% CI = 0.24-2.34). After 2 years, the corresponding treatment effects were +1.72% (95% CI = 0.12-3.34), +1.85% (95% CI = 0.51-3.20), and +2.30% (95% CI = 0.66-3.94), respectively.Oral clodronate appears to reduce the loss of BMD in patients who receive treatment for primary breast cancer." @default.
• W2130251213 created "2016-06-24" @default.
• W2130251213 creator A5000185916 @default.
• W2130251213 creator A5003291621 @default.
• W2130251213 creator A5007727706 @default.
• W2130251213 creator A5024668584 @default.
• W2130251213 creator A5024756058 @default.
• W2130251213 creator A5028513125 @default.
• W2130251213 creator A5037004738 @default.
• W2130251213 creator A5042591479 @default.
• W2130251213 date "1998-05-06" @default.
• W2130251213 modified "2023-09-25" @default.
• W2130251213 title "Oral Clodronate and Reduction in Loss of Bone Mineral Density in Women With Operable Primary Breast Cancer" @default.
• W2130251213 cites W1800396987 @default.
• W2130251213 cites W1906721103 @default.
• W2130251213 cites W1975500686 @default.
• W2130251213 cites W1979115901 @default.
• W2130251213 cites W1981476886 @default.
• W2130251213 cites W2034606501 @default.
• W2130251213 cites W2049760032 @default.
• W2130251213 cites W2072789990 @default.
• W2130251213 cites W2114358979 @default.
• W2130251213 cites W2127677509 @default.
• W2130251213 cites W2153108218 @default.
• W2130251213 cites W2167496620 @default.
• W2130251213 cites W2321227665 @default.
• W2130251213 doi "https://doi.org/10.1093/jnci/90.9.704" @default.
• W2130251213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9586668" @default.
• W2130251213 hasPublicationYear "1998" @default.
• W2130251213 type Work @default.
• W2130251213 sameAs 2130251213 @default.
• W2130251213 citedByCount "154" @default.
• W2130251213 countsByYear W21302512132012 @default.
• W2130251213 countsByYear W21302512132013 @default.
• W2130251213 countsByYear W21302512132014 @default.
• W2130251213 countsByYear W21302512132015 @default.
• W2130251213 countsByYear W21302512132016 @default.
• W2130251213 countsByYear W21302512132017 @default.
• W2130251213 countsByYear W21302512132018 @default.
• W2130251213 countsByYear W21302512132019 @default.
• W2130251213 countsByYear W21302512132020 @default.
• W2130251213 countsByYear W21302512132021 @default.
• W2130251213 countsByYear W21302512132023 @default.
• W2130251213 crossrefType "journal-article" @default.
• W2130251213 hasAuthorship W2130251213A5000185916 @default.
• W2130251213 hasAuthorship W2130251213A5003291621 @default.
• W2130251213 hasAuthorship W2130251213A5007727706 @default.
• W2130251213 hasAuthorship W2130251213A5024668584 @default.
• W2130251213 hasAuthorship W2130251213A5024756058 @default.
• W2130251213 hasAuthorship W2130251213A5028513125 @default.
• W2130251213 hasAuthorship W2130251213A5037004738 @default.
• W2130251213 hasAuthorship W2130251213A5042591479 @default.
• W2130251213 hasBestOaLocation W21302512131 @default.
• W2130251213 hasConcept C121608353 @default.
• W2130251213 hasConcept C126322002 @default.
• W2130251213 hasConcept C126894567 @default.
• W2130251213 hasConcept C141071460 @default.
• W2130251213 hasConcept C142724271 @default.
• W2130251213 hasConcept C204787440 @default.
• W2130251213 hasConcept C27081682 @default.
• W2130251213 hasConcept C2776541429 @default.
• W2130251213 hasConcept C2776548296 @default.
• W2130251213 hasConcept C2776886416 @default.
• W2130251213 hasConcept C2777176818 @default.
• W2130251213 hasConcept C2777251235 @default.
• W2130251213 hasConcept C530470458 @default.
• W2130251213 hasConcept C71924100 @default.
• W2130251213 hasConceptScore W2130251213C121608353 @default.
• W2130251213 hasConceptScore W2130251213C126322002 @default.
• W2130251213 hasConceptScore W2130251213C126894567 @default.
• W2130251213 hasConceptScore W2130251213C141071460 @default.
• W2130251213 hasConceptScore W2130251213C142724271 @default.
• W2130251213 hasConceptScore W2130251213C204787440 @default.
• W2130251213 hasConceptScore W2130251213C27081682 @default.
• W2130251213 hasConceptScore W2130251213C2776541429 @default.
• W2130251213 hasConceptScore W2130251213C2776548296 @default.
• W2130251213 hasConceptScore W2130251213C2776886416 @default.
• W2130251213 hasConceptScore W2130251213C2777176818 @default.
• W2130251213 hasConceptScore W2130251213C2777251235 @default.
• W2130251213 hasConceptScore W2130251213C530470458 @default.
• W2130251213 hasConceptScore W2130251213C71924100 @default.
• W2130251213 hasIssue "9" @default.
• W2130251213 hasLocation W21302512131 @default.
• W2130251213 hasLocation W21302512132 @default.
• W2130251213 hasOpenAccess W2130251213 @default.
• W2130251213 hasPrimaryLocation W21302512131 @default.
• W2130251213 hasRelatedWork W1991922719 @default.
• W2130251213 hasRelatedWork W2109065346 @default.
• W2130251213 hasRelatedWork W2189065230 @default.
• W2130251213 hasRelatedWork W2412158022 @default.
• W2130251213 hasRelatedWork W2435118099 @default.
• W2130251213 hasRelatedWork W2553291045 @default.
• W2130251213 hasRelatedWork W3145348386 @default.
• W2130251213 hasRelatedWork W3203771908 @default.
• W2130251213 hasRelatedWork W1908094710 @default.
• W2130251213 hasRelatedWork W2156941679 @default.
• W2130251213 hasVolume "90" @default.
• W2130251213 isParatext "false" @default.

• next