Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130266019> ?p ?o ?g. }
- W2130266019 endingPage "1144" @default.
- W2130266019 startingPage "1130" @default.
- W2130266019 abstract "Depleted of dopamine, the dynamics of the parkinsonian brain impact on both ‘action’ and ‘resting’ motor behaviour. Deep brain stimulation has become an established means of managing these symptoms, although its mechanisms of action remain unclear. Non-invasive characterizations of induced brain responses, and the effective connectivity underlying them, generally appeals to dynamic causal modelling of neuroimaging data. When the brain is at rest, however, this sort of characterization has been limited to correlations (functional connectivity). In this work, we model the ‘effective’ connectivity underlying low frequency blood oxygen level-dependent fluctuations in the resting Parkinsonian motor network—disclosing the distributed effects of deep brain stimulation on cortico-subcortical connections. Specifically, we show that subthalamic nucleus deep brain stimulation modulates all the major components of the motor cortico-striato-thalamo-cortical loop, including the cortico-striatal, thalamo-cortical, direct and indirect basal ganglia pathways, and the hyperdirect subthalamic nucleus projections. The strength of effective subthalamic nucleus afferents and efferents were reduced by stimulation, whereas cortico-striatal, thalamo-cortical and direct pathways were strengthened. Remarkably, regression analysis revealed that the hyperdirect, direct, and basal ganglia afferents to the subthalamic nucleus predicted clinical status and therapeutic response to deep brain stimulation; however, suppression of the sensitivity of the subthalamic nucleus to its hyperdirect afferents by deep brain stimulation may subvert the clinical efficacy of deep brain stimulation. Our findings highlight the distributed effects of stimulation on the resting motor network and provide a framework for analysing effective connectivity in resting state functional MRI with strong a priori hypotheses." @default.
- W2130266019 created "2016-06-24" @default.
- W2130266019 creator A5006880808 @default.
- W2130266019 creator A5019175331 @default.
- W2130266019 creator A5020377507 @default.
- W2130266019 creator A5026509971 @default.
- W2130266019 creator A5029378962 @default.
- W2130266019 creator A5034198230 @default.
- W2130266019 creator A5040249146 @default.
- W2130266019 creator A5079076250 @default.
- W2130266019 creator A5079394225 @default.
- W2130266019 creator A5083676325 @default.
- W2130266019 creator A5086852785 @default.
- W2130266019 creator A5088463655 @default.
- W2130266019 creator A5088629634 @default.
- W2130266019 creator A5088646126 @default.
- W2130266019 date "2014-02-24" @default.
- W2130266019 modified "2023-09-27" @default.
- W2130266019 title "Resting state functional MRI in Parkinson’s disease: the impact of deep brain stimulation on ‘effective’ connectivity" @default.
- W2130266019 cites W1526465516 @default.
- W2130266019 cites W1586994437 @default.
- W2130266019 cites W1807195566 @default.
- W2130266019 cites W1909924204 @default.
- W2130266019 cites W1968187292 @default.
- W2130266019 cites W1969266707 @default.
- W2130266019 cites W1970416621 @default.
- W2130266019 cites W1970695058 @default.
- W2130266019 cites W1970994015 @default.
- W2130266019 cites W1971797700 @default.
- W2130266019 cites W1973504049 @default.
- W2130266019 cites W1980489779 @default.
- W2130266019 cites W1982827121 @default.
- W2130266019 cites W1983297775 @default.
- W2130266019 cites W1987095365 @default.
- W2130266019 cites W1991606582 @default.
- W2130266019 cites W1998444969 @default.
- W2130266019 cites W2003214519 @default.
- W2130266019 cites W2003435725 @default.
- W2130266019 cites W2004951400 @default.
- W2130266019 cites W2006807981 @default.
- W2130266019 cites W2006950383 @default.
- W2130266019 cites W2009494091 @default.
- W2130266019 cites W2012730273 @default.
- W2130266019 cites W2012769853 @default.
- W2130266019 cites W2015224800 @default.
- W2130266019 cites W2016625584 @default.
- W2130266019 cites W2018822471 @default.
- W2130266019 cites W2021655476 @default.
- W2130266019 cites W2028590620 @default.
- W2130266019 cites W2032370847 @default.
- W2130266019 cites W2037475926 @default.
- W2130266019 cites W2037544016 @default.
- W2130266019 cites W2047471489 @default.
- W2130266019 cites W2049711835 @default.
- W2130266019 cites W2050943404 @default.
- W2130266019 cites W2054625530 @default.
- W2130266019 cites W2054798847 @default.
- W2130266019 cites W2055331506 @default.
- W2130266019 cites W2057435588 @default.
- W2130266019 cites W2060588252 @default.
- W2130266019 cites W2060756235 @default.
- W2130266019 cites W2060856236 @default.
- W2130266019 cites W2068789581 @default.
- W2130266019 cites W2070290883 @default.
- W2130266019 cites W2074616189 @default.
- W2130266019 cites W2079911953 @default.
- W2130266019 cites W2080847728 @default.
- W2130266019 cites W2081375777 @default.
- W2130266019 cites W2083932518 @default.
- W2130266019 cites W2087322473 @default.
- W2130266019 cites W2091439238 @default.
- W2130266019 cites W2091594001 @default.
- W2130266019 cites W2092133053 @default.
- W2130266019 cites W2095270577 @default.
- W2130266019 cites W2096875305 @default.
- W2130266019 cites W2096892963 @default.
- W2130266019 cites W2098303658 @default.
- W2130266019 cites W2098527346 @default.
- W2130266019 cites W2100948940 @default.
- W2130266019 cites W2101249624 @default.
- W2130266019 cites W2116136260 @default.
- W2130266019 cites W2117663940 @default.
- W2130266019 cites W2123908362 @default.
- W2130266019 cites W2132128336 @default.
- W2130266019 cites W2135173838 @default.
- W2130266019 cites W2137922965 @default.
- W2130266019 cites W2139037554 @default.
- W2130266019 cites W2140684369 @default.
- W2130266019 cites W2141405085 @default.
- W2130266019 cites W2144351977 @default.
- W2130266019 cites W2146853248 @default.
- W2130266019 cites W2156276536 @default.
- W2130266019 cites W2156743548 @default.
- W2130266019 cites W2159087357 @default.
- W2130266019 cites W2171670117 @default.
- W2130266019 cites W2208230172 @default.
- W2130266019 cites W4249210107 @default.
- W2130266019 doi "https://doi.org/10.1093/brain/awu027" @default.