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• W2130303312 abstract "Objective . Diabetic nephropathy is associated with low-grade inflammation and activation of the complement system. Defensins, as part of the innate immune system, may play a regulatory role in the complement cascade and may also augment the production of proinflammatory cytokines. The aim of this study was therefore to elucidate whether α-defensin is associated with diabetic nephropathy, low-grade inflammation and lipid profiles. Research design and methods . Data were obtained from 189 patients with type 1 diabetes selected from the FinnDiane Study. Patients were divided into three groups according to their albumin excretion rate (AER) in three consecutive overnight or 24-h urine collections: normoalbuminuria (AER <20 μg/min or <30 mg/24 h), microalbuminuria (20 <AER <200 μg/min or 30 <AER <300 mg/24 h) and macroalbuminuria (>200 μg/min or >300 mg/24 h). α-Defensin was determined by a novel, solid-phase radioimmunoassay (RIA) based on a monoclonal antibody, which recognizes α-defensin isoforms 1–3. Results . Total serum α-defensin (-1, -2 and -3) concentrations were higher ( P < 0.001) in patients with macroalbuminuria compared to micro- and normoalbuminuria, but no difference was observed between normoalbuminuria and microalbuminuria. In multiple linear regression analysis α-defensin was associated with systolic blood pressure ( P = 0.032), HDL-cholesterol ( P = 0.013), total cholesterol ( P = 0.008), age ( P = 0.001) and estimated glomerular filtration rate ( P = 0.001), but not with low-grade inflammatory markers. Conclusions . Serum α-defensin (-1, -2 and -3) concentrations are increased in type 1 diabetic patients with diabetic nephropathy." @default.
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• W2130303312 date "2007-10-15" @default.
• W2130303312 modified "2023-09-27" @default.
• W2130303312 title "Increased levels of -defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy" @default.
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• W2130303312 doi "https://doi.org/10.1093/ndt/gfm711" @default.
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