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• W2130323007 abstract "Although it is often tacitly assumed that gene regulatory interactions are finely tuned, how accurate gene regulation could evolve from a state without regulation is unclear. Moreover, gene expression noise would seem to impede the evolution of accurate gene regulation, and previous investigations have provided circumstantial evidence that natural selection has acted to lower noise levels. By evolving synthetic Escherichia coli promoters de novo, we here show that, contrary to expectations, promoters exhibit low noise by default. Instead, selection must have acted to increase the noise levels of highly regulated E. coli promoters. We present a general theory of the interplay between gene expression noise and gene regulation that explains these observations. The theory shows that propagation of expression noise from regulators to their targets is not an unwanted side-effect of regulation, but rather acts as a rudimentary form of regulation that facilitates the evolution of more accurate regulation." @default.
• W2130323007 created "2016-06-24" @default.
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• W2130323007 creator A5052508586 @default.
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• W2130323007 date "2015-06-17" @default.
• W2130323007 modified "2023-10-03" @default.
• W2130323007 title "Expression noise facilitates the evolution of gene regulation" @default.
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• W2130323007 doi "https://doi.org/10.7554/elife.05856" @default.
• W2130323007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4468965" @default.
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• W2130323007 hasPublicationYear "2015" @default.
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