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• W2130347002 abstract "Accumulating evidence suggests that spinal astrocytes play an important role in the genesis of persistent pain, by increasing the activity of spinal cord nociceptive neurons, i.e., central sensitization. However, direct evidence of whether activation of astrocytes is sufficient to induce chronic pain symptoms is lacking. We investigated whether and how spinal injection of activated astrocytes could produce mechanical allodynia, a cardinal feature of chronic pain, in naïve mice. Spinal (intrathecal) injection of astrocytes, which were prepared from cerebral cortexes of neonatal mice and briefly stimulated by tumor necrosis factor-alpha (TNF-α), induced a substantial decrease in paw withdrawal thresholds, indicating the development of mechanical allodynia. This allodynia was prevented when the astrocyte cultures were pretreated with a peptide inhibitor of c-Jun N-terminal kinase (JNK), D-JNKI-1. Of note a short exposure of astrocytes to TNF-α for 15 min dramatically increased the expression and release of the chemokine monocyte chemoattractant protein-1 (MCP-1), even 3 h after TNF-α withdrawal, in a JNK-dependent manner. In parallel, intrathecal administration of TNF-α induced MCP-1 expression in spinal cord astrocytes. In particular, mechanical allodynia induced by TNF-α-activated astrocytes was reversed by a MCP-1 neutralizing antibody. Finally, pretreatment of astrocytes with MCP-1 siRNA attenuated astrocytes-induced mechanical allodynia. Taken together, our results suggest that activated astrocytes are sufficient to produce persistent pain symptom in naïve mice by releasing MCP-1. © 2010 Wiley-Liss, Inc." @default.
• W2130347002 created "2016-06-24" @default.
• W2130347002 creator A5017163037 @default.
• W2130347002 creator A5048001261 @default.
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• W2130347002 date "2010-08-24" @default.
• W2130347002 modified "2023-10-16" @default.
• W2130347002 title "Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1" @default.
• W2130347002 cites W1550940982 @default.
• W2130347002 cites W1841237986 @default.
• W2130347002 cites W1959229569 @default.
• W2130347002 cites W1966537796 @default.
• W2130347002 cites W1966543080 @default.
• W2130347002 cites W1967916273 @default.
• W2130347002 cites W1968402792 @default.
• W2130347002 cites W1971063834 @default.
• W2130347002 cites W1972907659 @default.
• W2130347002 cites W1976142920 @default.
• W2130347002 cites W1983273439 @default.
• W2130347002 cites W1984025105 @default.
• W2130347002 cites W1984526977 @default.
• W2130347002 cites W1985763589 @default.
• W2130347002 cites W1987408946 @default.
• W2130347002 cites W1988855325 @default.
• W2130347002 cites W1989821508 @default.
• W2130347002 cites W1990445317 @default.
• W2130347002 cites W1993285878 @default.
• W2130347002 cites W1997283068 @default.
• W2130347002 cites W2000814289 @default.
• W2130347002 cites W2003542915 @default.
• W2130347002 cites W2003830841 @default.
• W2130347002 cites W2006161356 @default.
• W2130347002 cites W2009812771 @default.
• W2130347002 cites W2023830878 @default.
• W2130347002 cites W2025544444 @default.
• W2130347002 cites W2034102455 @default.
• W2130347002 cites W2040299229 @default.
• W2130347002 cites W2040443501 @default.
• W2130347002 cites W2042707882 @default.
• W2130347002 cites W2043974564 @default.
• W2130347002 cites W2044597171 @default.
• W2130347002 cites W2047794539 @default.
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• W2130347002 cites W2059646315 @default.
• W2130347002 cites W2062712759 @default.
• W2130347002 cites W2062873434 @default.
• W2130347002 cites W2066796908 @default.
• W2130347002 cites W2067637071 @default.
• W2130347002 cites W2074149762 @default.
• W2130347002 cites W2076905284 @default.
• W2130347002 cites W2077885131 @default.
• W2130347002 cites W2088284560 @default.
• W2130347002 cites W2090863733 @default.
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• W2130347002 doi "https://doi.org/10.1002/glia.21056" @default.
• W2130347002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2951489" @default.
• W2130347002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20737477" @default.
• W2130347002 hasPublicationYear "2010" @default.
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