Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130351489> ?p ?o ?g. }
- W2130351489 endingPage "203" @default.
- W2130351489 startingPage "191" @default.
- W2130351489 abstract "Posttraumatic stress disorder (PTSD) is an anxiety disorder that can develop following exposure to a traumatic event, including terrifying or life-threatening situations such as sexual assault or natural disasters. The disorder is characterized by a reaction of intense fear, helplessness, or horror when the individual experiences, testifies about, or is faced with one or more events that involve death, severe wounds, or a threat to one's own or another's physical integrity. One of the most important symptoms of PTSD is the revival of the traumatic event, which has been interpreted as an inability to downregulate negative emotions. Neuroimaging studies that probed the ability to regulate emotions in healthy volunteers have found a pattern characterized by activation of the prefrontal cortex associated with a reduction in amygdala activity. This suggests an inhibitory prefrontal cortex-amygdala circuit that underlies emotional regulation. The hypothesis that increased amygdala activation associated with PTSD results from dysfunction in the inhibitory mechanism exerted by the prefrontal cortex has been the topic of debate. The present review investigates the validity of dysfunction in the prefrontal-amygdala pathway in PTSD. The studies provide evidence that the amygdala and prefrontal cortex exhibit distinct activation patterns in PTSD, thus supporting the model of a dysfunctional circuit. Inconsistencies in the literature may be attributable to distinct PTSD subgroups, different experimental approaches, different contrasts employed in neuroimaging studies, and small sample sizes." @default.
- W2130351489 created "2016-06-24" @default.
- W2130351489 creator A5000925869 @default.
- W2130351489 creator A5004413871 @default.
- W2130351489 creator A5038125492 @default.
- W2130351489 creator A5047446159 @default.
- W2130351489 creator A5065074832 @default.
- W2130351489 creator A5074425176 @default.
- W2130351489 creator A5076183669 @default.
- W2130351489 creator A5089042908 @default.
- W2130351489 date "2011-01-01" @default.
- W2130351489 modified "2023-09-30" @default.
- W2130351489 title "The neurobiology of posttraumatic stress disorder: Dysfunction in the prefrontal-amygdala circuit?" @default.
- W2130351489 cites W101520166 @default.
- W2130351489 cites W1964851255 @default.
- W2130351489 cites W1967996189 @default.
- W2130351489 cites W1979460778 @default.
- W2130351489 cites W1979955047 @default.
- W2130351489 cites W1981030752 @default.
- W2130351489 cites W1981205427 @default.
- W2130351489 cites W1984030600 @default.
- W2130351489 cites W1984624900 @default.
- W2130351489 cites W1987793892 @default.
- W2130351489 cites W1988021886 @default.
- W2130351489 cites W1988875934 @default.
- W2130351489 cites W1990379520 @default.
- W2130351489 cites W1992882861 @default.
- W2130351489 cites W1997714535 @default.
- W2130351489 cites W2001403885 @default.
- W2130351489 cites W2003344388 @default.
- W2130351489 cites W2006500510 @default.
- W2130351489 cites W2007516104 @default.
- W2130351489 cites W2008286604 @default.
- W2130351489 cites W2009746681 @default.
- W2130351489 cites W2011904866 @default.
- W2130351489 cites W2012819349 @default.
- W2130351489 cites W2013016395 @default.
- W2130351489 cites W2015451929 @default.
- W2130351489 cites W2015892174 @default.
- W2130351489 cites W2016660677 @default.
- W2130351489 cites W2025266605 @default.
- W2130351489 cites W2025911957 @default.
- W2130351489 cites W2026720425 @default.
- W2130351489 cites W2031636627 @default.
- W2130351489 cites W2034545593 @default.
- W2130351489 cites W2036970657 @default.
- W2130351489 cites W2037216547 @default.
- W2130351489 cites W2041000222 @default.
- W2130351489 cites W2046845602 @default.
- W2130351489 cites W2049812132 @default.
- W2130351489 cites W2051340798 @default.
- W2130351489 cites W2051751124 @default.
- W2130351489 cites W2055711129 @default.
- W2130351489 cites W2057988711 @default.
- W2130351489 cites W2061092474 @default.
- W2130351489 cites W2064029491 @default.
- W2130351489 cites W2065338158 @default.
- W2130351489 cites W2065623558 @default.
- W2130351489 cites W2066525901 @default.
- W2130351489 cites W2067302347 @default.
- W2130351489 cites W2069831089 @default.
- W2130351489 cites W2070017221 @default.
- W2130351489 cites W2070594067 @default.
- W2130351489 cites W2072484079 @default.
- W2130351489 cites W2075986471 @default.
- W2130351489 cites W2079326418 @default.
- W2130351489 cites W2083201121 @default.
- W2130351489 cites W2084732347 @default.
- W2130351489 cites W2085230334 @default.
- W2130351489 cites W2091308025 @default.
- W2130351489 cites W2092354644 @default.
- W2130351489 cites W2092796129 @default.
- W2130351489 cites W2100429814 @default.
- W2130351489 cites W2102393246 @default.
- W2130351489 cites W2102748276 @default.
- W2130351489 cites W2108655964 @default.
- W2130351489 cites W2109167188 @default.
- W2130351489 cites W2109414445 @default.
- W2130351489 cites W2110134839 @default.
- W2130351489 cites W2110747672 @default.
- W2130351489 cites W2111006812 @default.
- W2130351489 cites W2114221514 @default.
- W2130351489 cites W2115084515 @default.
- W2130351489 cites W2115274607 @default.
- W2130351489 cites W2117177930 @default.
- W2130351489 cites W2120357670 @default.
- W2130351489 cites W2124556602 @default.
- W2130351489 cites W2126043033 @default.
- W2130351489 cites W2127485482 @default.
- W2130351489 cites W2127909094 @default.
- W2130351489 cites W2128126978 @default.
- W2130351489 cites W2128918541 @default.
- W2130351489 cites W2133664593 @default.
- W2130351489 cites W2137050989 @default.
- W2130351489 cites W2137084838 @default.
- W2130351489 cites W2138903473 @default.
- W2130351489 cites W2144463055 @default.
- W2130351489 cites W2146747402 @default.