Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130366212> ?p ?o ?g. }
- W2130366212 endingPage "39" @default.
- W2130366212 startingPage "25" @default.
- W2130366212 abstract "Formation of a complex between the tyrosine kinases FAK and Src is a key integrin-mediated signaling event implicated in cell motility, survival, and proliferation. Past studies indicate that FAK functions in the complex primarily as a “scaffold,” acting to recruit and activate Src within cell/matrix adhesions. To study the cellular impact of FAK-associated Src signaling we developed a novel gain-of-function approach that involves expressing a chimeric protein with the FAK kinase domain replaced by the Src kinase domain. This FAK/Src chimera is subject to adhesion-dependent activation and promotes tyrosine phosphorylation of p130Cas and paxillin to higher steady-state levels than is achieved by wild-type FAK. When expressed in FAK −/− mouse embryo fibroblasts, the FAK/Src chimera resulted in a striking cellular phenotype characterized by unusual large peripheral adhesions, enhanced adhesive strength, and greatly reduced motility. Live cell imaging of the chimera-expressing FAK −/− cells provided evidence that the large peripheral adhesions are associated with a dynamic actin assembly process that is sensitive to a Src-selective inhibitor. These findings suggest that FAK-associated Src kinase activity has the capacity to promote adhesion integrity and actin assembly. Cell Motil. Cytoskeleton 2008. © 2007 Wiley-Liss, Inc." @default.
- W2130366212 created "2016-06-24" @default.
- W2130366212 creator A5003299767 @default.
- W2130366212 creator A5007275872 @default.
- W2130366212 creator A5011208920 @default.
- W2130366212 creator A5016617544 @default.
- W2130366212 creator A5026469210 @default.
- W2130366212 creator A5046493895 @default.
- W2130366212 creator A5061535468 @default.
- W2130366212 creator A5083502883 @default.
- W2130366212 date "2008-01-01" @default.
- W2130366212 modified "2023-10-06" @default.
- W2130366212 title "A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly" @default.
- W2130366212 cites W1516960913 @default.
- W2130366212 cites W1532590486 @default.
- W2130366212 cites W1845277443 @default.
- W2130366212 cites W1850765736 @default.
- W2130366212 cites W1929023701 @default.
- W2130366212 cites W1965397720 @default.
- W2130366212 cites W1969678475 @default.
- W2130366212 cites W1977656622 @default.
- W2130366212 cites W1979757399 @default.
- W2130366212 cites W1988664861 @default.
- W2130366212 cites W1995035107 @default.
- W2130366212 cites W1995426006 @default.
- W2130366212 cites W1999916818 @default.
- W2130366212 cites W2006892275 @default.
- W2130366212 cites W2012012447 @default.
- W2130366212 cites W2018250952 @default.
- W2130366212 cites W2024262880 @default.
- W2130366212 cites W2025018535 @default.
- W2130366212 cites W2028586282 @default.
- W2130366212 cites W2028691987 @default.
- W2130366212 cites W2034246730 @default.
- W2130366212 cites W2040258779 @default.
- W2130366212 cites W2041062798 @default.
- W2130366212 cites W2041200273 @default.
- W2130366212 cites W2042423118 @default.
- W2130366212 cites W2043151616 @default.
- W2130366212 cites W2044895919 @default.
- W2130366212 cites W2048209624 @default.
- W2130366212 cites W2054779757 @default.
- W2130366212 cites W2077080652 @default.
- W2130366212 cites W2094173028 @default.
- W2130366212 cites W2098518658 @default.
- W2130366212 cites W2099158550 @default.
- W2130366212 cites W2105356859 @default.
- W2130366212 cites W2105512558 @default.
- W2130366212 cites W2114462664 @default.
- W2130366212 cites W2116045343 @default.
- W2130366212 cites W2119055543 @default.
- W2130366212 cites W2120346794 @default.
- W2130366212 cites W2121645463 @default.
- W2130366212 cites W2121905156 @default.
- W2130366212 cites W2135546209 @default.
- W2130366212 cites W2142042013 @default.
- W2130366212 cites W2142682878 @default.
- W2130366212 cites W2145072524 @default.
- W2130366212 cites W2148541235 @default.
- W2130366212 cites W2150020603 @default.
- W2130366212 cites W2152898182 @default.
- W2130366212 cites W2160022719 @default.
- W2130366212 cites W2171179595 @default.
- W2130366212 cites W2310034942 @default.
- W2130366212 cites W4240762858 @default.
- W2130366212 cites W4249092084 @default.
- W2130366212 doi "https://doi.org/10.1002/cm.20241" @default.
- W2130366212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2387247" @default.
- W2130366212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17922492" @default.
- W2130366212 hasPublicationYear "2008" @default.
- W2130366212 type Work @default.
- W2130366212 sameAs 2130366212 @default.
- W2130366212 citedByCount "14" @default.
- W2130366212 countsByYear W21303662122012 @default.
- W2130366212 countsByYear W21303662122014 @default.
- W2130366212 countsByYear W21303662122016 @default.
- W2130366212 countsByYear W21303662122017 @default.
- W2130366212 countsByYear W21303662122020 @default.
- W2130366212 crossrefType "journal-article" @default.
- W2130366212 hasAuthorship W2130366212A5003299767 @default.
- W2130366212 hasAuthorship W2130366212A5007275872 @default.
- W2130366212 hasAuthorship W2130366212A5011208920 @default.
- W2130366212 hasAuthorship W2130366212A5016617544 @default.
- W2130366212 hasAuthorship W2130366212A5026469210 @default.
- W2130366212 hasAuthorship W2130366212A5046493895 @default.
- W2130366212 hasAuthorship W2130366212A5061535468 @default.
- W2130366212 hasAuthorship W2130366212A5083502883 @default.
- W2130366212 hasBestOaLocation W21303662122 @default.
- W2130366212 hasConcept C108391706 @default.
- W2130366212 hasConcept C108636557 @default.
- W2130366212 hasConcept C116581196 @default.
- W2130366212 hasConcept C11960822 @default.
- W2130366212 hasConcept C125705527 @default.
- W2130366212 hasConcept C141073059 @default.
- W2130366212 hasConcept C142669718 @default.
- W2130366212 hasConcept C1491633281 @default.
- W2130366212 hasConcept C151166631 @default.
- W2130366212 hasConcept C195687474 @default.