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• W2130391361 abstract "ABSTRACT Immune suppression by Treg has been demonstrated in a number of models, but the mechanisms of this suppression are only partly understood. Recent work has suggested that Tregs may suppress by directly killing immune cell populations in vivo in a perforin- and granzyme B-dependent manner. To establish whether perforin is necessary for the regulation of immune responses in vivo, we examined OVA-specific CD8+ T cell responses in WT and PKO mice immunized with OVA and α-GalCer and the expansion of WT OT-I CD8+ T cells adoptively transferred into WT or PKO mice immunized with DC-OVA. We observed similar expansion, phenotype, and effector function of CD8+ T cells in WT and PKO mice, suggesting that CD8+ T cells were subjected to a similar amount of regulation in the two mouse strains. In addition, when WT and PKO mice were depleted of Tregs by anti-CD25 mAb treatment before DC-OVA immunization, CD8+ T cell proliferation, cytotoxicity, and cytokine production were increased similarly, suggesting a comparable involvement of CD25+ Tregs in controlling T cell proliferation and effector function in these two mouse strains. These data suggest that perforin expression is not required for normal immune regulation in these models of in vivo CD8+ T cell responses induced by immunization with OVA and α-GalCer or DC-OVA." @default.
• W2130391361 created "2016-06-24" @default.
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• W2130391361 date "2013-10-01" @default.
• W2130391361 modified "2023-10-18" @default.
• W2130391361 title "The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+CD25+ regulatory T cells" @default.
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• W2130391361 doi "https://doi.org/10.1189/jlb.0413200" @default.
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• W2130391361 hasPublicationYear "2013" @default.
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