FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130393733> ?p ?o ?g. }

• W2130393733 abstract "Abstract Background Despite evident success of malaria control in many sites in the Arabian Peninsula, malaria remains endemic in a few spots, in Yemen and south-west of Saudi Arabia. In addition to local transmission, imported malaria sustains an extra source of parasites that can challenge the strengths of local control strategies. This study examined the genetic diversity of Plasmodium falciparum in Yemen and mutations of drug resistant genes, to elucidate parasite structure and distribution of drug resistance genotypes in the region. Methods Five polymorphic loci ( MSP-2 , Pfg377 and three microsatellites on chromosome 8) not involved in anti-malarial drug resistance, and four drug resistant genes ( pfcrt , pfmdr1 , dhfr and dhps ) were genotyped in 108 P . falciparum isolates collected in three sites in Yemen: Dhamar, Hodeidah and Taiz. Results High diversity was seen in non-drug genes, pfg377 ( He = 0.66), msp - 2 ( He = 0.80) and three microsatellites on chr 8, 7.7 kb ( He = 0.88), 4.3 kb ( He = 0.77) and 0.8 kb ( He = 0.71). There was a high level of mixed-genotype infections (57%), with an average 1.8 genotypes per patient. No linkage disequilibrium was seen between drug resistant genes and the non-drug markers (p < 0.05). Genetic differentiation between populations was low (most pair-wise F ST values <0.03), indicating extensive gene flow between the parasites in the three sites. There was a high prevalence of mutations in pfmdr1 , pfcrt and dhfr ; with four mutant pfmdr1 genotypes (NFCDD[57%], NFSND[21%], YFCDD[13%] and YFSND[8% ]), two mutant pfcrt genotypes (CVIET[89%] and SVMNT[4%]) and one mutant dhfr genotype (ICNI[53.7%]). However, no dhps mutations were detected. Conclusion The high diversity of P . falciparum in Yemen is indicative of a large parasite reservoir, which represents a challenge to control efforts. The presence of two distinct pfcrt genotype, CVIET and SVMNT, suggests that chloroquine resistance can possibly be related to a migratory path from Africa and Asia. The absence of the triple mutant dhfr genotype (IRN) and dhps mutations supports the use of artesunate + sulphadoxine-pyrimethamine as first-line therapy. However, the prevalent pfmdr1 genotype NFSND [21%] has previously been associated with tolerance/resistance response to artemisinin combination therapy (ACT). Regular surveys are, therefore, important to monitor spread of pfmdr1 and dhfr mutations and response to ACT." @default.
• W2130393733 created "2016-06-24" @default.
• W2130393733 creator A5006465705 @default.
• W2130393733 creator A5011107206 @default.
• W2130393733 creator A5038439031 @default.
• W2130393733 creator A5042846985 @default.
• W2130393733 creator A5047191357 @default.
• W2130393733 creator A5047718061 @default.
• W2130393733 creator A5074246982 @default.
• W2130393733 creator A5088604696 @default.
• W2130393733 date "2013-07-15" @default.
• W2130393733 modified "2023-10-17" @default.
• W2130393733 title "Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen" @default.
• W2130393733 cites W1594650890 @default.
• W2130393733 cites W1838568970 @default.
• W2130393733 cites W1965607692 @default.
• W2130393733 cites W1970947265 @default.
• W2130393733 cites W1972177048 @default.
• W2130393733 cites W1977659500 @default.
• W2130393733 cites W1984669077 @default.
• W2130393733 cites W1987063801 @default.
• W2130393733 cites W2003076429 @default.
• W2130393733 cites W2009021681 @default.
• W2130393733 cites W2013275306 @default.
• W2130393733 cites W2019777313 @default.
• W2130393733 cites W2020897015 @default.
• W2130393733 cites W2029237652 @default.
• W2130393733 cites W2034520962 @default.
• W2130393733 cites W2041076069 @default.
• W2130393733 cites W2050609691 @default.
• W2130393733 cites W2051454092 @default.
• W2130393733 cites W2054836932 @default.
• W2130393733 cites W2056568340 @default.
• W2130393733 cites W2056639403 @default.
• W2130393733 cites W2064783051 @default.
• W2130393733 cites W2066069334 @default.
• W2130393733 cites W2075072369 @default.
• W2130393733 cites W2076050649 @default.
• W2130393733 cites W2079451231 @default.
• W2130393733 cites W2086851905 @default.
• W2130393733 cites W2088791835 @default.
• W2130393733 cites W2091586468 @default.
• W2130393733 cites W2110076538 @default.
• W2130393733 cites W2110601288 @default.
• W2130393733 cites W2118248316 @default.
• W2130393733 cites W2119357339 @default.
• W2130393733 cites W2120868166 @default.
• W2130393733 cites W2122827495 @default.
• W2130393733 cites W2123262041 @default.
• W2130393733 cites W2123284622 @default.
• W2130393733 cites W2125300370 @default.
• W2130393733 cites W2127396309 @default.
• W2130393733 cites W2129105877 @default.
• W2130393733 cites W2129185882 @default.
• W2130393733 cites W2132923209 @default.
• W2130393733 cites W2135178447 @default.
• W2130393733 cites W2137189778 @default.
• W2130393733 cites W2137764200 @default.
• W2130393733 cites W2155925360 @default.
• W2130393733 cites W2157765820 @default.
• W2130393733 cites W2160884305 @default.
• W2130393733 cites W2162629756 @default.
• W2130393733 cites W2164272027 @default.
• W2130393733 cites W2167792128 @default.
• W2130393733 cites W2169671369 @default.
• W2130393733 cites W2170874271 @default.
• W2130393733 cites W2333050857 @default.
• W2130393733 cites W4254570155 @default.
• W2130393733 cites W4318471195 @default.
• W2130393733 cites W2066769716 @default.
• W2130393733 doi "https://doi.org/10.1186/1475-2875-12-244" @default.
• W2130393733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3729657" @default.
• W2130393733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23855834" @default.
• W2130393733 hasPublicationYear "2013" @default.
• W2130393733 type Work @default.
• W2130393733 sameAs 2130393733 @default.
• W2130393733 citedByCount "24" @default.
• W2130393733 countsByYear W21303937332013 @default.
• W2130393733 countsByYear W21303937332014 @default.
• W2130393733 countsByYear W21303937332015 @default.
• W2130393733 countsByYear W21303937332016 @default.
• W2130393733 countsByYear W21303937332019 @default.
• W2130393733 countsByYear W21303937332020 @default.
• W2130393733 countsByYear W21303937332021 @default.
• W2130393733 countsByYear W21303937332022 @default.
• W2130393733 countsByYear W21303937332023 @default.
• W2130393733 crossrefType "journal-article" @default.
• W2130393733 hasAuthorship W2130393733A5006465705 @default.
• W2130393733 hasAuthorship W2130393733A5011107206 @default.
• W2130393733 hasAuthorship W2130393733A5038439031 @default.
• W2130393733 hasAuthorship W2130393733A5042846985 @default.
• W2130393733 hasAuthorship W2130393733A5047191357 @default.
• W2130393733 hasAuthorship W2130393733A5047718061 @default.
• W2130393733 hasAuthorship W2130393733A5074246982 @default.
• W2130393733 hasAuthorship W2130393733A5088604696 @default.
• W2130393733 hasBestOaLocation W21303937331 @default.
• W2130393733 hasConcept C104317684 @default.
• W2130393733 hasConcept C114851261 @default.
• W2130393733 hasConcept C135763542 @default.
• W2130393733 hasConcept C159047783 @default.

• next