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• W2130394977 abstract "In vitro studies have suggested that the TatBC complex serves as the receptor for signal peptides targeted for export via the twin-arginine translocation (Tat) pathway. Substitution of the hallmark twin-arginine dipeptide with two lysines abrogates export of physiological substrates in all organisms. We report the isolation and characterization of suppressor mutations that allow export of an ssTor(KK)-GFP-SsrA tripartite fusion. We identified two amino acid suppressor mutations in the first cytoplasmic loop of TatC. In addition, two other amino acids in the first cytoplasmic loop exhibit epistatic suppression. Surprisingly, we also identified a suppressor mutation predicted to lie within the second periplasmic loop of TatC, a region that is not expected to interact directly with the signal peptide. The suppressor mutations allowed export of the native Esherichia coli Tat substrate trimethylamine N-oxide reductase with a twin-lysine substitution in its signal sequence. The cytoplasmic suppressor mutations conferred SDS sensitivity and partial filamentation, indicating that Tat export of authentic substrates was impaired." @default.
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• W2130394977 creator A5047788420 @default.
• W2130394977 date "2007-11-01" @default.
• W2130394977 modified "2023-09-23" @default.
• W2130394977 title "Escherichia coli tatC Mutations that Suppress Defective Twin-Arginine Transporter Signal Peptides" @default.
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• W2130394977 doi "https://doi.org/10.1016/j.jmb.2007.09.050" @default.
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