FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130394993> ?p ?o ?g. }

• W2130394993 endingPage "631" @default.
• W2130394993 startingPage "621" @default.
• W2130394993 abstract "Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipid deposition has not been quantified. To determine the impact acetate-treatment has on cellular lipid content, we investigated the effect of acetate in the presence of bacterial lipopolysaccharide (LPS) on fatty acid, phospholipid, and cholesterol content in BV2 microglia. We found that 1, 5, and 10 mM of acetate in the presence of LPS increased the total fatty acid content in BV2 cells by 23, 34, and 14 % at 2 h, respectively. Significant increases in individual fatty acids were also observed with all acetate concentrations tested with the greatest increases occurring with 5 mM acetate in the presence of LPS. Treatment with 5 mM acetate in the absence of LPS increased total cholesterol levels by 11 %. However, neither treatment in the absence of LPS significantly altered the content of individual phospholipids or total phospholipid content. To determine the minimum effective concentration of acetate we measured the time- and concentration-dependent changes in histone acetylation using western blot analysis. These studies showed that 5 mM acetate was necessary to induce histone acetylation and at 10 mM acetate, the histone acetylation-state increased as early as 0.5 h following the start of treatment. These data suggest that acetate increases fatty acid content in LPS-stimulated BV2 microglia that is reflected by an increase in fatty acids esterified into membrane phospholipids." @default.
• W2130394993 created "2016-06-24" @default.
• W2130394993 creator A5012289981 @default.
• W2130394993 creator A5078195421 @default.
• W2130394993 date "2014-05-23" @default.
• W2130394993 modified "2023-10-17" @default.
• W2130394993 title "Acetate Treatment Increases Fatty Acid Content in LPS-Stimulated BV2 Microglia" @default.
• W2130394993 cites W1544076228 @default.
• W2130394993 cites W1669217149 @default.
• W2130394993 cites W1911505635 @default.
• W2130394993 cites W1912783338 @default.
• W2130394993 cites W1924667250 @default.
• W2130394993 cites W1966129095 @default.
• W2130394993 cites W1967981220 @default.
• W2130394993 cites W1968533993 @default.
• W2130394993 cites W1969023959 @default.
• W2130394993 cites W1974580919 @default.
• W2130394993 cites W1983616310 @default.
• W2130394993 cites W1997812608 @default.
• W2130394993 cites W2000013518 @default.
• W2130394993 cites W2011748028 @default.
• W2130394993 cites W2014374346 @default.
• W2130394993 cites W2018169050 @default.
• W2130394993 cites W2023704083 @default.
• W2130394993 cites W2039326711 @default.
• W2130394993 cites W2045720893 @default.
• W2130394993 cites W2053022788 @default.
• W2130394993 cites W2053646374 @default.
• W2130394993 cites W2054064045 @default.
• W2130394993 cites W2061070921 @default.
• W2130394993 cites W2069411519 @default.
• W2130394993 cites W2071124826 @default.
• W2130394993 cites W2077705158 @default.
• W2130394993 cites W2087714970 @default.
• W2130394993 cites W2090091665 @default.
• W2130394993 cites W2091457094 @default.
• W2130394993 cites W2100476416 @default.
• W2130394993 cites W2125872855 @default.
• W2130394993 cites W2136815314 @default.
• W2130394993 cites W2145958122 @default.
• W2130394993 cites W2153367244 @default.
• W2130394993 cites W2158435581 @default.
• W2130394993 cites W2165889171 @default.
• W2130394993 cites W2166708512 @default.
• W2130394993 cites W27897481 @default.
• W2130394993 cites W4231395949 @default.
• W2130394993 cites W4293247451 @default.
• W2130394993 cites W4361865119 @default.
• W2130394993 doi "https://doi.org/10.1007/s11745-014-3911-x" @default.
• W2130394993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24852320" @default.
• W2130394993 hasPublicationYear "2014" @default.
• W2130394993 type Work @default.
• W2130394993 sameAs 2130394993 @default.
• W2130394993 citedByCount "5" @default.
• W2130394993 countsByYear W21303949932017 @default.
• W2130394993 countsByYear W21303949932021 @default.
• W2130394993 countsByYear W21303949932022 @default.
• W2130394993 countsByYear W21303949932023 @default.
• W2130394993 crossrefType "journal-article" @default.
• W2130394993 hasAuthorship W2130394993A5012289981 @default.
• W2130394993 hasAuthorship W2130394993A5078195421 @default.
• W2130394993 hasConcept C104317684 @default.
• W2130394993 hasConcept C119157956 @default.
• W2130394993 hasConcept C126322002 @default.
• W2130394993 hasConcept C134018914 @default.
• W2130394993 hasConcept C185592680 @default.
• W2130394993 hasConcept C2778754761 @default.
• W2130394993 hasConcept C2778918659 @default.
• W2130394993 hasConcept C41625074 @default.
• W2130394993 hasConcept C543025807 @default.
• W2130394993 hasConcept C55493867 @default.
• W2130394993 hasConcept C71924100 @default.
• W2130394993 hasConcept C86803240 @default.
• W2130394993 hasConceptScore W2130394993C104317684 @default.
• W2130394993 hasConceptScore W2130394993C119157956 @default.
• W2130394993 hasConceptScore W2130394993C126322002 @default.
• W2130394993 hasConceptScore W2130394993C134018914 @default.
• W2130394993 hasConceptScore W2130394993C185592680 @default.
• W2130394993 hasConceptScore W2130394993C2778754761 @default.
• W2130394993 hasConceptScore W2130394993C2778918659 @default.
• W2130394993 hasConceptScore W2130394993C41625074 @default.
• W2130394993 hasConceptScore W2130394993C543025807 @default.
• W2130394993 hasConceptScore W2130394993C55493867 @default.
• W2130394993 hasConceptScore W2130394993C71924100 @default.
• W2130394993 hasConceptScore W2130394993C86803240 @default.
• W2130394993 hasIssue "7" @default.
• W2130394993 hasLocation W21303949931 @default.
• W2130394993 hasLocation W21303949932 @default.
• W2130394993 hasOpenAccess W2130394993 @default.
• W2130394993 hasPrimaryLocation W21303949931 @default.
• W2130394993 hasRelatedWork W2030400955 @default.
• W2130394993 hasRelatedWork W2060643724 @default.
• W2130394993 hasRelatedWork W2074579052 @default.
• W2130394993 hasRelatedWork W2096284471 @default.
• W2130394993 hasRelatedWork W2113751484 @default.
• W2130394993 hasRelatedWork W2136518857 @default.
• W2130394993 hasRelatedWork W2145943006 @default.
• W2130394993 hasRelatedWork W2148711924 @default.

• next