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• W2130401538 endingPage "624" @default.
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• W2130401538 abstract "Microglial activation plays a pivotal role in the pathogenesis of neurodegenerative disease by producing excessive proinflammatory cytokines and nitric oxide (NO). Luteolin, a naturally occurring polyphenolic flavonoid antioxidant, has potent anti-inflammatory and neuroprotective properties both in vitro and in vivo. However, the molecular mechanism of luteolin-mediated immune modulation in microglia is not fully understood. In the present study, we report the inhibitory effect of luteolin on lipopolysaccharide (LPS)/interferon γ (IFN-γ)-induced NO and proinflammatory cytokine production in rat primary microglia and BV-2 microglial cells. Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. Biochemical and pharmacological studies revealed that the anti-inflammatory effect of luteolin was accompanied by down-regulation of extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt and Src. Further studies have demonstrated that the inhibitory effect of luteolin on intracellular signaling execution and proinflammatory cytokine expression is associated with resolution of oxidative stress and promotion of protein phosphatase activity. Together, these results suggest that luteolin suppresses NF-κB, STAT1 and IRF-1 signaling, thus attenuating inflammatory response of brain microglial cells." @default.
• W2130401538 created "2016-06-24" @default.
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• W2130401538 date "2011-07-01" @default.
• W2130401538 modified "2023-09-25" @default.
• W2130401538 title "Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia" @default.
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• W2130401538 cites W1925689439 @default.
• W2130401538 cites W1935626365 @default.
• W2130401538 cites W1967493112 @default.
• W2130401538 cites W1974924674 @default.
• W2130401538 cites W1978000487 @default.
• W2130401538 cites W1978259871 @default.
• W2130401538 cites W1978701756 @default.
• W2130401538 cites W1979292955 @default.
• W2130401538 cites W1985146518 @default.
• W2130401538 cites W1987781980 @default.
• W2130401538 cites W1988254695 @default.
• W2130401538 cites W1988652043 @default.
• W2130401538 cites W1989708376 @default.
• W2130401538 cites W1990667071 @default.
• W2130401538 cites W1992419290 @default.
• W2130401538 cites W1995623391 @default.
• W2130401538 cites W1998462656 @default.
• W2130401538 cites W2004453024 @default.
• W2130401538 cites W2005953884 @default.
• W2130401538 cites W2018451712 @default.
• W2130401538 cites W2021029373 @default.
• W2130401538 cites W2024493724 @default.
• W2130401538 cites W2033728878 @default.
• W2130401538 cites W2036285327 @default.
• W2130401538 cites W2038781543 @default.
• W2130401538 cites W2039348922 @default.
• W2130401538 cites W2043290296 @default.
• W2130401538 cites W2056211408 @default.
• W2130401538 cites W2060980402 @default.
• W2130401538 cites W2064318120 @default.
• W2130401538 cites W2064647661 @default.
• W2130401538 cites W2072985973 @default.
• W2130401538 cites W2073838528 @default.
• W2130401538 cites W2080424432 @default.
• W2130401538 cites W2081552862 @default.
• W2130401538 cites W2081762967 @default.
• W2130401538 cites W2084603096 @default.
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• W2130401538 doi "https://doi.org/10.1016/j.jnutbio.2010.01.011" @default.
• W2130401538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21036586" @default.
• W2130401538 hasPublicationYear "2011" @default.
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