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- W2130409824 endingPage "1030" @default.
- W2130409824 startingPage "1019" @default.
- W2130409824 abstract "Microbial immune evasion can be achieved through the expression, or mimicry, of host-like carbohydrates on the microbial cell surface to hide from detection. However, disparate reports collectively suggest that evasion could also be accomplished through the modulation of the host glycosylation pathways, a mechanism that we call the “Glyco-Evasion Hypothesis”. Here, we will summarize the evidence in support of this paradigm by reviewing three separate bodies of work present in the literature. We review how infection and inflammation can lead to host glycosylation changes, how host glycosylation changes can increase susceptibility to infection and inflammation and how glycosylation impacts molecular and cellular function. Then, using these data as a foundation, we propose a unifying hypothesis in which microbial products can hijack host glycosylation to manipulate the immune response to the advantage of the pathogen. This model reveals areas of research that we believe could significantly improve our fight against infectious disease." @default.
- W2130409824 created "2016-06-24" @default.
- W2130409824 creator A5031675998 @default.
- W2130409824 creator A5046791728 @default.
- W2130409824 date "2012-04-05" @default.
- W2130409824 modified "2023-09-27" @default.
- W2130409824 title "Infection, inflammation and host carbohydrates: A Glyco-Evasion Hypothesis" @default.
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