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• W2130428093 abstract "Abstract— The GABA‐elevating agents, aminooxyacetic acid, hydrazine, and hydroxylamine, all possessed anticonvulsant properties, although to a widely varying degree. Aminooxyacetic acid was the most efficacious in delaying drug‐induced seizures in mice whereas hydroxylamine brought about only a slight delay in the onset of seizures. The anticonvulsant action was observed against various convulsant agents regardless of whether the convulsant mechanism might involve a deranged GABA metabolism (allylglycine, isonicotinic acid hydrazide, hydrazine), an interference with GABA function (picrotoxin) or some other mechanism (pentylenetetrazol). The anticonvulsant action was not related in a simple manner to either GABA levels or glutamic acid decarboxylase (GAD) activities but the anomalous situation whereby seizures occurred when the GABA content of brain was above normal could be resolved on the basis of an expression which included changes in both GABA levels and GAD activity. The possibility was proposed that the anticonvulsant action of aminooxyacetic acid involved two separate mechanisms." @default.
• W2130428093 created "2016-06-24" @default.
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• W2130428093 creator A5085334539 @default.
• W2130428093 date "1975-09-01" @default.
• W2130428093 modified "2023-10-09" @default.
• W2130428093 title "THE ANTICONVULSANT ACTION OF GABA-ELEVATING AGENTS: A RE-EVALUATION" @default.
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• W2130428093 doi "https://doi.org/10.1111/j.1471-4159.1975.tb06966.x" @default.
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