FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130431025> ?p ?o ?g. }

• W2130431025 endingPage "1271" @default.
• W2130431025 startingPage "1264" @default.
• W2130431025 abstract "Administration of selective and nonselective cyclooxygenase (COX)-2 inhibitors to rheumatoid arthritis patients taking low doses of acetylsalicylic acid (ASA) for cardiovascular prevention associates with increased risk of gastrointestinal bleeding. The present study was undertaken to investigate whether administration of HCT-3012 [(<i>S</i>)-6-methoxy-α-methyl-2-naphthaleneacetic acid 4-(nitrooxy)butyl ester], a nitric oxide (NO)-releasing derivative of naproxen, exacerbates gastric mucosal injury in arthritic rats administered low doses of ASA. Our results demonstrated that while treating arthritic rats with a dose of 30 mg/kg/day ASA causes detectable mucosal injury, but had no effect on arthritis score and interleukin-6 plasma levels, coadministration of naproxen (10 mg/kg/day) and celecoxib (30 mg/kg/day), in combination with ASA from day 7 to day 21, attenuates arthritis development (<i>P</i> < 0.01 versus arthritis alone), but markedly enhanced gastric mucosal damage caused by ASA (<i>P</i> < 0.01 versus ASA alone). In contrast, coadministration of HCT-3012 (15 mg/kg/day) significantly attenuated arthritis development, because HCT-3012 was equally or more effective than naproxen and celecoxib in attenuating local and systemic inflammation (<i>P</i> > 0.001 versus arthritis) without exacerbating gastric mucosal injury caused by ASA. Arthritis development associates with gastric COX-2 induction, mRNA and protein, and enhanced gastric prostaglandin E₂ (PGE₂) synthesis (<i>P</i> < 0.01 versus control rats). Although all treatments, including celecoxib, were effective in reducing gastric PGE₂ synthesis, administering arthritic rats with ASA resulted in a significant increase in gastric content of aspirin-triggered lipoxin (ATL), a COX-2-derived lipid mediator that regulates proinflammatory responses at the neutrophils/endothelial interface. Administering arthritic rats with naproxen and celecoxib abrogates ATL formation induced by ASA although enhanced neutrophils accumulate into the gastric mucosa (<i>P</i> < 0.01 versus ASA alone). In contrast, whereas HCT-3012 inhibited ATL formation, it did not increase neutrophil recruitment into the gastric microcirculation. Collectively, these data indicate that HCT-3012 derived from NO has the potential to compensate for inhibition of PGE₂ and ATL and to protect the gastric mucosa by limiting the recruitment of neutrophils. These data suggest that HCT-3012 might be a safer alternative to nonsteroidal anti-inflammatory drugs and coxibs in rheumatic patients that take low doses of ASA." @default.
• W2130431025 created "2016-06-24" @default.
• W2130431025 creator A5016113649 @default.
• W2130431025 creator A5028850531 @default.
• W2130431025 creator A5048653552 @default.
• W2130431025 creator A5057720130 @default.
• W2130431025 creator A5065994871 @default.
• W2130431025 creator A5082173292 @default.
• W2130431025 date "2004-08-05" @default.
• W2130431025 modified "2023-09-25" @default.
• W2130431025 title "Nitric Oxide (NO)-Releasing Naproxen (HCT-3012 [(S)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid 4-(Nitrooxy)butyl Ester]) Interactions with Aspirin in Gastric Mucosa of Arthritic Rats Reveal a Role for Aspirin-Triggered Lipoxin, Prostaglandins, and NO in Gastric Protection" @default.
• W2130431025 cites W1657319651 @default.
• W2130431025 cites W1660326086 @default.
• W2130431025 cites W1971236330 @default.
• W2130431025 cites W1973123971 @default.
• W2130431025 cites W1983759759 @default.
• W2130431025 cites W1985458126 @default.
• W2130431025 cites W1987212025 @default.
• W2130431025 cites W1994464747 @default.
• W2130431025 cites W2002540320 @default.
• W2130431025 cites W2007187686 @default.
• W2130431025 cites W2011071242 @default.
• W2130431025 cites W2019954713 @default.
• W2130431025 cites W2020036617 @default.
• W2130431025 cites W2021905899 @default.
• W2130431025 cites W2023887529 @default.
• W2130431025 cites W2030894817 @default.
• W2130431025 cites W2037179116 @default.
• W2130431025 cites W2042401508 @default.
• W2130431025 cites W2055855948 @default.
• W2130431025 cites W2057727574 @default.
• W2130431025 cites W2063401681 @default.
• W2130431025 cites W2071201771 @default.
• W2130431025 cites W2073059894 @default.
• W2130431025 cites W2073833391 @default.
• W2130431025 cites W2074075127 @default.
• W2130431025 cites W2079341705 @default.
• W2130431025 cites W2088179332 @default.
• W2130431025 cites W2099864223 @default.
• W2130431025 cites W2110628158 @default.
• W2130431025 cites W2123386718 @default.
• W2130431025 cites W2131868847 @default.
• W2130431025 cites W2149933060 @default.
• W2130431025 cites W2153875779 @default.
• W2130431025 cites W2162382352 @default.
• W2130431025 cites W2162465757 @default.
• W2130431025 cites W2163756514 @default.
• W2130431025 cites W2279164415 @default.
• W2130431025 cites W2280291187 @default.
• W2130431025 cites W2330496155 @default.
• W2130431025 cites W2331216347 @default.
• W2130431025 cites W4229941561 @default.
• W2130431025 cites W4235059441 @default.
• W2130431025 doi "https://doi.org/10.1124/jpet.104.072843" @default.
• W2130431025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15297470" @default.
• W2130431025 hasPublicationYear "2004" @default.
• W2130431025 type Work @default.
• W2130431025 sameAs 2130431025 @default.
• W2130431025 citedByCount "27" @default.
• W2130431025 countsByYear W21304310252014 @default.
• W2130431025 countsByYear W21304310252016 @default.
• W2130431025 countsByYear W21304310252017 @default.
• W2130431025 crossrefType "journal-article" @default.
• W2130431025 hasAuthorship W2130431025A5016113649 @default.
• W2130431025 hasAuthorship W2130431025A5028850531 @default.
• W2130431025 hasAuthorship W2130431025A5048653552 @default.
• W2130431025 hasAuthorship W2130431025A5057720130 @default.
• W2130431025 hasAuthorship W2130431025A5065994871 @default.
• W2130431025 hasAuthorship W2130431025A5082173292 @default.
• W2130431025 hasConcept C126322002 @default.
• W2130431025 hasConcept C142724271 @default.
• W2130431025 hasConcept C181199279 @default.
• W2130431025 hasConcept C185592680 @default.
• W2130431025 hasConcept C203565725 @default.
• W2130431025 hasConcept C204787440 @default.
• W2130431025 hasConcept C2776467144 @default.
• W2130431025 hasConcept C2776914184 @default.
• W2130431025 hasConcept C2777077863 @default.
• W2130431025 hasConcept C2777575956 @default.
• W2130431025 hasConcept C2777628954 @default.
• W2130431025 hasConcept C2777956040 @default.
• W2130431025 hasConcept C2778115740 @default.
• W2130431025 hasConcept C2779422922 @default.
• W2130431025 hasConcept C2779689624 @default.
• W2130431025 hasConcept C2781443798 @default.
• W2130431025 hasConcept C519581460 @default.
• W2130431025 hasConcept C55493867 @default.
• W2130431025 hasConcept C71924100 @default.
• W2130431025 hasConcept C98274493 @default.
• W2130431025 hasConceptScore W2130431025C126322002 @default.
• W2130431025 hasConceptScore W2130431025C142724271 @default.
• W2130431025 hasConceptScore W2130431025C181199279 @default.
• W2130431025 hasConceptScore W2130431025C185592680 @default.
• W2130431025 hasConceptScore W2130431025C203565725 @default.
• W2130431025 hasConceptScore W2130431025C204787440 @default.
• W2130431025 hasConceptScore W2130431025C2776467144 @default.
• W2130431025 hasConceptScore W2130431025C2776914184 @default.
• W2130431025 hasConceptScore W2130431025C2777077863 @default.

• next