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• W2130431539 abstract "CTLs and NK cells use the perforin/granzyme cytotoxic pathway to kill virally infected cells and tumors. Human regulatory T cells also express functional granzymes and perforin and can induce autologous target cell death in vitro. Perforin-deficient mice die of excessive immune responses after viral challenges, implicating a potential role for this pathway in immune regulation. To further investigate the role of granzyme B in immune regulation in response to viral infections, we characterized the immune response in wild-type, granzyme B-deficient, and perforin-deficient mice infected with Sendai virus. Interestingly, granzyme B-deficient mice, and to a lesser extent perforin-deficient mice, exhibited a significant increase in the number of Ag-specific CD8(+) T cells in the lungs and draining lymph nodes of virally infected animals. This increase was not the result of failure in viral clearance because viral titers in granzyme B-deficient mice were similar to wild-type mice and significantly less than perforin-deficient mice. Regulatory T cells from WT mice expressed high levels of granzyme B in response to infection, and depletion of regulatory T cells from these mice resulted in an increase in the number of Ag-specific CD8(+) T cells, similar to that observed in granzyme B-deficient mice. Furthermore, granzyme B-deficient regulatory T cells displayed defective suppression of CD8(+) T cell proliferation in vitro. Taken together, these results suggest a role for granzyme B in the regulatory T cell compartment in immune regulation to viral infections." @default.
• W2130431539 created "2016-06-24" @default.
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• W2130431539 date "2011-12-15" @default.
• W2130431539 modified "2023-10-01" @default.
• W2130431539 title "Granzyme B Regulates Antiviral CD8+ T Cell Responses" @default.
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• W2130431539 doi "https://doi.org/10.4049/jimmunol.1100891" @default.
• W2130431539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3237805" @default.
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• W2130431539 hasPublicationYear "2011" @default.
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