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• W2130432743 abstract "We have used a phospholipase C (PLC)-deletion mutant (plcABC) of the H37Rv strain of Mycobacterium tuberculosis (MTB), as well as a plcA-insertion mutant of Mycobacterium smegmatis, to investigate the possible involvement of PLCs in clofazimine-mediated inhibition of mycobacterial K(+) transport and growth. Inactivation of the PLCs of MTB and insertion of the plcA gene into M. smegmatis resulted in a substantial reduction and increase in hydrolysis of phosphatidylcholine (PC), respectively. However, both the mutant and wild-type strains of MTB and M. smegmatis were equally sensitive to the inhibitory effects of clofazimine on K(+) uptake and growth. These observations demonstrate that the PLCs of MTB are not involved in the antimicrobial activity of clofazimine." @default.
• W2130432743 created "2016-06-24" @default.
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• W2130432743 date "2004-04-29" @default.
• W2130432743 modified "2023-10-17" @default.
• W2130432743 title "Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases" @default.
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• W2130432743 doi "https://doi.org/10.1093/jac/dkh215" @default.
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