FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130449909> ?p ?o ?g. }

• W2130449909 endingPage "9679" @default.
• W2130449909 startingPage "9665" @default.
• W2130449909 abstract "ABSTRACT The feline immunodeficiency virus (FIV) targets activated CD4-positive helper T cells preferentially, inducing an AIDS-like immunodeficiency in its natural host species, the domestic cat. The primary receptor for FIV is CD134, a member of the tumor necrosis factor receptor superfamily, and all primary viral strains tested to date use CD134 for infection. We examined the expression of CD134 in the cat using a novel anti-feline CD134 monoclonal antibody (MAb), 7D6, and showed that as in rats and humans, CD134 expression is restricted tightly to CD4 + , and not CD8 + , T cells, consistent with the selective targeting of these cells by FIV. However, FIV is also macrophage tropic, and in chronic infection the viral tropism broadens to include B cells and CD8 + T cells. Using 7D6, we revealed CD134 expression on a B220-positive (B-cell) population and on cultured macrophages but not peripheral blood monocytes. Moreover, macrophage CD134 expression and FIV infection were enhanced by activation in response to bacterial lipopolysaccharide. Consistent with CD134 expression on human and murine T cells, feline CD134 was abundant on mitogen-stimulated CD4 + T cells, with weaker expression on CD8 + T cells, concordant with the expansion of FIV into CD8 + T cells with progression of the infection. The interaction between FIV and CD134 was probed using MAb 7D6 and soluble CD134 ligand (CD134L), revealing strain-specific differences in sensitivity to both 7D6 and CD134L. Infection with isolates such as PPR and B2542 was inhibited well by both 7D6 and CD134L, suggesting a lower affinity of interaction. In contrast, GL8, CPG, and NCSU were relatively refractory to inhibition by both 7D6 and CD134L and, accordingly, may have a higher-affinity interaction with CD134, permitting infection of cells where CD134 levels are limiting." @default.
• W2130449909 created "2016-06-24" @default.
• W2130449909 creator A5001836075 @default.
• W2130449909 creator A5045281805 @default.
• W2130449909 creator A5050947572 @default.
• W2130449909 creator A5053104890 @default.
• W2130449909 creator A5065830204 @default.
• W2130449909 creator A5090001718 @default.
• W2130449909 date "2007-09-15" @default.
• W2130449909 modified "2023-09-26" @default.
• W2130449909 title "Probing the Interaction between Feline Immunodeficiency Virus and CD134 by Using the Novel Monoclonal Antibody 7D6 and the CD134 (O×40) Ligand" @default.
• W2130449909 cites W1539868110 @default.
• W2130449909 cites W1683411584 @default.
• W2130449909 cites W1920473099 @default.
• W2130449909 cites W1964093851 @default.
• W2130449909 cites W1972881887 @default.
• W2130449909 cites W1974428835 @default.
• W2130449909 cites W1993421126 @default.
• W2130449909 cites W2021519801 @default.
• W2130449909 cites W2037992039 @default.
• W2130449909 cites W2039038215 @default.
• W2130449909 cites W2044307925 @default.
• W2130449909 cites W2046382304 @default.
• W2130449909 cites W2047096766 @default.
• W2130449909 cites W2049029765 @default.
• W2130449909 cites W2051803876 @default.
• W2130449909 cites W2053642404 @default.
• W2130449909 cites W2075769056 @default.
• W2130449909 cites W2082361721 @default.
• W2130449909 cites W2082715693 @default.
• W2130449909 cites W2084557405 @default.
• W2130449909 cites W2091848213 @default.
• W2130449909 cites W2098715950 @default.
• W2130449909 cites W2108256128 @default.
• W2130449909 cites W2113559201 @default.
• W2130449909 cites W2113765407 @default.
• W2130449909 cites W2116206761 @default.
• W2130449909 cites W2119636254 @default.
• W2130449909 cites W2123458220 @default.
• W2130449909 cites W2124167813 @default.
• W2130449909 cites W2125258814 @default.
• W2130449909 cites W2127238148 @default.
• W2130449909 cites W2129304651 @default.
• W2130449909 cites W2129857470 @default.
• W2130449909 cites W2138094990 @default.
• W2130449909 cites W2138887185 @default.
• W2130449909 cites W2142154986 @default.
• W2130449909 cites W2158692057 @default.
• W2130449909 doi "https://doi.org/10.1128/jvi.01020-07" @default.
• W2130449909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045395" @default.
• W2130449909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17609274" @default.
• W2130449909 hasPublicationYear "2007" @default.
• W2130449909 type Work @default.
• W2130449909 sameAs 2130449909 @default.
• W2130449909 citedByCount "22" @default.
• W2130449909 countsByYear W21304499092012 @default.
• W2130449909 countsByYear W21304499092013 @default.
• W2130449909 countsByYear W21304499092014 @default.
• W2130449909 countsByYear W21304499092017 @default.
• W2130449909 countsByYear W21304499092018 @default.
• W2130449909 countsByYear W21304499092020 @default.
• W2130449909 crossrefType "journal-article" @default.
• W2130449909 hasAuthorship W2130449909A5001836075 @default.
• W2130449909 hasAuthorship W2130449909A5045281805 @default.
• W2130449909 hasAuthorship W2130449909A5050947572 @default.
• W2130449909 hasAuthorship W2130449909A5053104890 @default.
• W2130449909 hasAuthorship W2130449909A5065830204 @default.
• W2130449909 hasAuthorship W2130449909A5090001718 @default.
• W2130449909 hasBestOaLocation W21304499091 @default.
• W2130449909 hasConcept C147483822 @default.
• W2130449909 hasConcept C153911025 @default.
• W2130449909 hasConcept C154317977 @default.
• W2130449909 hasConcept C159047783 @default.
• W2130449909 hasConcept C159654299 @default.
• W2130449909 hasConcept C167672396 @default.
• W2130449909 hasConcept C17991360 @default.
• W2130449909 hasConcept C202751555 @default.
• W2130449909 hasConcept C203014093 @default.
• W2130449909 hasConcept C2522874641 @default.
• W2130449909 hasConcept C2776090121 @default.
• W2130449909 hasConcept C2777841672 @default.
• W2130449909 hasConcept C2779690655 @default.
• W2130449909 hasConcept C2780727368 @default.
• W2130449909 hasConcept C542903549 @default.
• W2130449909 hasConcept C55493867 @default.
• W2130449909 hasConcept C86803240 @default.
• W2130449909 hasConcept C8891405 @default.
• W2130449909 hasConcept C95444343 @default.
• W2130449909 hasConceptScore W2130449909C147483822 @default.
• W2130449909 hasConceptScore W2130449909C153911025 @default.
• W2130449909 hasConceptScore W2130449909C154317977 @default.
• W2130449909 hasConceptScore W2130449909C159047783 @default.
• W2130449909 hasConceptScore W2130449909C159654299 @default.
• W2130449909 hasConceptScore W2130449909C167672396 @default.
• W2130449909 hasConceptScore W2130449909C17991360 @default.
• W2130449909 hasConceptScore W2130449909C202751555 @default.
• W2130449909 hasConceptScore W2130449909C203014093 @default.
• W2130449909 hasConceptScore W2130449909C2522874641 @default.

• next