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• W2130479997 startingPage "F123" @default.
• W2130479997 abstract "Irritable bowel syndrome and interstitial cystitis frequently overlap. We have shown that acute colitis sensitizes urinary bladder afferents to both mechanical and chemical stimuli and that chronic colitis similarly produces neurogenic cystitis. We hypothesize that chronic irritation of the colon releases neuropeptides from bladder afferents, leading to receptor sensitization and neurogenic inflammation. Female Sprague-Dawley rats received intrarectal trinitrobenzenesulfonic acid (TNBS) or vehicle 3 days following either systemic capsaicin (CP) pretreatment or vehicle. Ten days later, action potentials of single-unit pelvic C-fiber afferents with receptive fields in the bladder were recorded under urethane anesthesia during graded bladder distensions (UBD) or intravesical capsaicin (vCP) administration. In controls, UBD increased bladder afferent firing in proportion to intravesical pressure. At intravesical pressures of 30 mmHg and above, the percent increase in afferent firing was significantly accentuated following TNBS compared with controls (1,222 ± 176 vs. 624 ± 54%, P < 0.01). The response to vCP was also enhanced (4,126 ± 775 vs. 1,979 ± 438%, P < 0.01). Systemic depletion of neuropeptides from sensory nerves abolished these effects. Histological examination of the bladders revealed an increase in mast cell density in TNBS-treated animals compared with controls (18.02 ± 1.25 vs. 3.11 ± 0.27 mast cells/×100 field, P < 0.01). This effect was significantly ameliorated with CP (10.25 ± 0.95, P < 0.5 vs. TNBS-treated animals). In summary, chronic colonic irritation in the rat sensitizes urinary bladder afferents to noxious stimuli and causes mast cell infiltration in the bladder. Depletion of neuropeptides from sensory afferents diminishes these effects, suggesting they play an important role." @default.
• W2130479997 created "2016-06-24" @default.
• W2130479997 creator A5015270250 @default.
• W2130479997 creator A5053129872 @default.
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• W2130479997 date "2007-01-01" @default.
• W2130479997 modified "2023-10-14" @default.
• W2130479997 title "Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides" @default.
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• W2130479997 doi "https://doi.org/10.1152/ajprenal.00162.2006" @default.
• W2130479997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16926445" @default.
• W2130479997 hasPublicationYear "2007" @default.
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