FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130480117> ?p ?o ?g. }

• W2130480117 endingPage "718" @default.
• W2130480117 startingPage "713" @default.
• W2130480117 abstract "The human immunodeficiency virus type 1 (HIV-1) gp120 exterior glycoprotein is conformationally flexible. Upon binding the host cell receptor, CD4, gp120 assumes a conformation that is able to bind the chemokine receptors CCR5 or CXCR4, which act as coreceptors for the virus. CD4-binding-site (CD4BS) antibodies are neutralizing antibodies elicited during natural infection that are directed against gp120 epitopes that overlap the binding site for CD4. Recent studies (S. H. Xiang et al., J. Virol. 76:9888-9899, 2002) suggest that CD4BS antibodies recognize conformations of gp120 distinct from the CD4-bound conformation. This predicts that the binding of CD4BS antibodies will inhibit chemokine receptor binding. Here, we show that Fab fragments and complete immunoglobulin molecules of CD4BS antibodies inhibit CD4-independent gp120 binding to CCR5 and cell-cell fusion mediated by CD4-independent HIV-1 envelope glycoproteins. These results are consistent with a model in which the binding of CD4BS antibodies limits the ability of gp120 to assume a conformation required for coreceptor binding." @default.
• W2130480117 created "2016-06-24" @default.
• W2130480117 creator A5010409007 @default.
• W2130480117 creator A5030750704 @default.
• W2130480117 creator A5043677118 @default.
• W2130480117 creator A5071476197 @default.
• W2130480117 date "2003-01-01" @default.
• W2130480117 modified "2023-09-23" @default.
• W2130480117 title "CD4 Binding Site Antibodies Inhibit Human Immunodeficiency Virus gp120 Envelope Glycoprotein Interaction with CCR5" @default.
• W2130480117 cites W1628484047 @default.
• W2130480117 cites W1794879226 @default.
• W2130480117 cites W1907672488 @default.
• W2130480117 cites W1908149672 @default.
• W2130480117 cites W1911432365 @default.
• W2130480117 cites W1942872605 @default.
• W2130480117 cites W1968785258 @default.
• W2130480117 cites W1968873679 @default.
• W2130480117 cites W1974587421 @default.
• W2130480117 cites W1977282539 @default.
• W2130480117 cites W1995355944 @default.
• W2130480117 cites W1997989849 @default.
• W2130480117 cites W2000861225 @default.
• W2130480117 cites W2008008404 @default.
• W2130480117 cites W2017551575 @default.
• W2130480117 cites W2022322687 @default.
• W2130480117 cites W2024734109 @default.
• W2130480117 cites W2025750305 @default.
• W2130480117 cites W2039028257 @default.
• W2130480117 cites W2039905832 @default.
• W2130480117 cites W2040159113 @default.
• W2130480117 cites W2063701397 @default.
• W2130480117 cites W2081291921 @default.
• W2130480117 cites W2095939962 @default.
• W2130480117 cites W2098781795 @default.
• W2130480117 cites W2099381548 @default.
• W2130480117 cites W2116715603 @default.
• W2130480117 cites W2131550599 @default.
• W2130480117 cites W2131903471 @default.
• W2130480117 cites W2131906141 @default.
• W2130480117 cites W2149956490 @default.
• W2130480117 cites W2162071888 @default.
• W2130480117 cites W2414254500 @default.
• W2130480117 doi "https://doi.org/10.1128/jvi.77.1.713-718.2003" @default.
• W2130480117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140634" @default.
• W2130480117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12477875" @default.
• W2130480117 hasPublicationYear "2003" @default.
• W2130480117 type Work @default.
• W2130480117 sameAs 2130480117 @default.
• W2130480117 citedByCount "28" @default.
• W2130480117 countsByYear W21304801172014 @default.
• W2130480117 countsByYear W21304801172015 @default.
• W2130480117 countsByYear W21304801172017 @default.
• W2130480117 countsByYear W21304801172019 @default.
• W2130480117 countsByYear W21304801172020 @default.
• W2130480117 countsByYear W21304801172021 @default.
• W2130480117 countsByYear W21304801172023 @default.
• W2130480117 crossrefType "journal-article" @default.
• W2130480117 hasAuthorship W2130480117A5010409007 @default.
• W2130480117 hasAuthorship W2130480117A5030750704 @default.
• W2130480117 hasAuthorship W2130480117A5043677118 @default.
• W2130480117 hasAuthorship W2130480117A5071476197 @default.
• W2130480117 hasBestOaLocation W21304801172 @default.
• W2130480117 hasConcept C107824862 @default.
• W2130480117 hasConcept C108625454 @default.
• W2130480117 hasConcept C12823836 @default.
• W2130480117 hasConcept C13373296 @default.
• W2130480117 hasConcept C153911025 @default.
• W2130480117 hasConcept C159047783 @default.
• W2130480117 hasConcept C159654299 @default.
• W2130480117 hasConcept C170493617 @default.
• W2130480117 hasConcept C195616568 @default.
• W2130480117 hasConcept C203014093 @default.
• W2130480117 hasConcept C2522874641 @default.
• W2130480117 hasConcept C45635710 @default.
• W2130480117 hasConcept C51639874 @default.
• W2130480117 hasConcept C55493867 @default.
• W2130480117 hasConcept C86803240 @default.
• W2130480117 hasConcept C95444343 @default.
• W2130480117 hasConcept C97380033 @default.
• W2130480117 hasConceptScore W2130480117C107824862 @default.
• W2130480117 hasConceptScore W2130480117C108625454 @default.
• W2130480117 hasConceptScore W2130480117C12823836 @default.
• W2130480117 hasConceptScore W2130480117C13373296 @default.
• W2130480117 hasConceptScore W2130480117C153911025 @default.
• W2130480117 hasConceptScore W2130480117C159047783 @default.
• W2130480117 hasConceptScore W2130480117C159654299 @default.
• W2130480117 hasConceptScore W2130480117C170493617 @default.
• W2130480117 hasConceptScore W2130480117C195616568 @default.
• W2130480117 hasConceptScore W2130480117C203014093 @default.
• W2130480117 hasConceptScore W2130480117C2522874641 @default.
• W2130480117 hasConceptScore W2130480117C45635710 @default.
• W2130480117 hasConceptScore W2130480117C51639874 @default.
• W2130480117 hasConceptScore W2130480117C55493867 @default.
• W2130480117 hasConceptScore W2130480117C86803240 @default.
• W2130480117 hasConceptScore W2130480117C95444343 @default.
• W2130480117 hasConceptScore W2130480117C97380033 @default.
• W2130480117 hasIssue "1" @default.
• W2130480117 hasLocation W21304801171 @default.

• next