FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130481749> ?p ?o ?g. }

• W2130481749 endingPage "4727" @default.
• W2130481749 startingPage "4719" @default.
• W2130481749 abstract "ABSTRACT Mannheimia haemolytica is the principal bacterial pathogen of the bovine respiratory disease complex. Its most important virulence factor is a leukotoxin (LKT), which is a member of the RTX family of exotoxins produced by many gram-negative bacteria. Previous studies demonstrated that LKT binds to the β 2 -integrin LFA-1 (CD11a/CD18) on bovine leukocytes, resulting in cell death. In this study, we demonstrated that depletion of lipid rafts significantly decreases LKT-induced bovine lymphoblastoid cell (BL-3) death. After binding to BL-3 cells, some of the LKT relocated to lipid rafts in an LFA-1-independent manner. We hypothesized that after binding to LFA-1 on BL-3 cells, LKT moves to lipid rafts and clathrin-coated pits via a dynamic process that results in LKT internalization and cytotoxicity. Knocking down dynamin-2 by small interfering RNA reduced both LKT internalization and cytotoxicity. Similarly, expression of dominant negative Eps15 protein expression, which is required for clathrin coat formation, reduced LKT internalization and LKT-mediated cytotoxicity to BL-3 cells. Finally, we demonstrated that inhibiting actin polymerization reduced both LKT internalization and LKT-mediated cytotoxicity. These results suggest that both lipid rafts and clathrin-mediated mechanisms are important for LKT internalization and cytotoxicity in BL-3 cells and illustrate the complex nature of LKT internalization by the cytoskeletal network." @default.
• W2130481749 created "2016-06-24" @default.
• W2130481749 creator A5045984658 @default.
• W2130481749 creator A5057148322 @default.
• W2130481749 date "2007-10-01" @default.
• W2130481749 modified "2023-10-11" @default.
• W2130481749 title "<i>Mannheimia haemolytica</i> Leukotoxin Binds to Lipid Rafts in Bovine Lymphoblastoid Cells and Is Internalized in a Dynamin-2- and Clathrin-Dependent Manner" @default.
• W2130481749 cites W1585347403 @default.
• W2130481749 cites W1864467270 @default.
• W2130481749 cites W1938835738 @default.
• W2130481749 cites W1965530119 @default.
• W2130481749 cites W1965572772 @default.
• W2130481749 cites W1965851529 @default.
• W2130481749 cites W1966765683 @default.
• W2130481749 cites W1968447388 @default.
• W2130481749 cites W1975285981 @default.
• W2130481749 cites W1976048635 @default.
• W2130481749 cites W1982712294 @default.
• W2130481749 cites W1982760200 @default.
• W2130481749 cites W1993357003 @default.
• W2130481749 cites W2006986579 @default.
• W2130481749 cites W2008103801 @default.
• W2130481749 cites W2012107438 @default.
• W2130481749 cites W2015320048 @default.
• W2130481749 cites W2018794902 @default.
• W2130481749 cites W2023286320 @default.
• W2130481749 cites W2028060446 @default.
• W2130481749 cites W2033239051 @default.
• W2130481749 cites W2036428031 @default.
• W2130481749 cites W2039242651 @default.
• W2130481749 cites W2047836270 @default.
• W2130481749 cites W2049121995 @default.
• W2130481749 cites W2055864348 @default.
• W2130481749 cites W2062452684 @default.
• W2130481749 cites W2067594620 @default.
• W2130481749 cites W2069128836 @default.
• W2130481749 cites W2071508744 @default.
• W2130481749 cites W2073038487 @default.
• W2130481749 cites W2096068443 @default.
• W2130481749 cites W2099162346 @default.
• W2130481749 cites W2108081370 @default.
• W2130481749 cites W2112153736 @default.
• W2130481749 cites W2124884345 @default.
• W2130481749 cites W2129044698 @default.
• W2130481749 cites W2129251085 @default.
• W2130481749 cites W2130779504 @default.
• W2130481749 cites W2131252883 @default.
• W2130481749 cites W2145730621 @default.
• W2130481749 cites W2146605982 @default.
• W2130481749 cites W2146662482 @default.
• W2130481749 cites W2155259994 @default.
• W2130481749 cites W2155743454 @default.
• W2130481749 cites W2155777849 @default.
• W2130481749 cites W2165992267 @default.
• W2130481749 cites W2171040244 @default.
• W2130481749 cites W2337218456 @default.
• W2130481749 cites W2395604880 @default.
• W2130481749 cites W4239340399 @default.
• W2130481749 cites W4243856904 @default.
• W2130481749 cites W43726920 @default.
• W2130481749 cites W6917144 @default.
• W2130481749 cites W69352699 @default.
• W2130481749 doi "https://doi.org/10.1128/iai.00534-07" @default.
• W2130481749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2044511" @default.
• W2130481749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17682044" @default.
• W2130481749 hasPublicationYear "2007" @default.
• W2130481749 type Work @default.
• W2130481749 sameAs 2130481749 @default.
• W2130481749 citedByCount "27" @default.
• W2130481749 countsByYear W21304817492012 @default.
• W2130481749 countsByYear W21304817492013 @default.
• W2130481749 countsByYear W21304817492015 @default.
• W2130481749 countsByYear W21304817492016 @default.
• W2130481749 countsByYear W21304817492018 @default.
• W2130481749 countsByYear W21304817492019 @default.
• W2130481749 countsByYear W21304817492020 @default.
• W2130481749 countsByYear W21304817492021 @default.
• W2130481749 crossrefType "journal-article" @default.
• W2130481749 hasAuthorship W2130481749A5045984658 @default.
• W2130481749 hasAuthorship W2130481749A5057148322 @default.
• W2130481749 hasBestOaLocation W21304817491 @default.
• W2130481749 hasConcept C109316439 @default.
• W2130481749 hasConcept C139770010 @default.
• W2130481749 hasConcept C1491633281 @default.
• W2130481749 hasConcept C156407911 @default.
• W2130481749 hasConcept C202751555 @default.
• W2130481749 hasConcept C28005876 @default.
• W2130481749 hasConcept C55493867 @default.
• W2130481749 hasConcept C62478195 @default.
• W2130481749 hasConcept C63162447 @default.
• W2130481749 hasConcept C79266657 @default.
• W2130481749 hasConcept C86803240 @default.
• W2130481749 hasConcept C95444343 @default.
• W2130481749 hasConceptScore W2130481749C109316439 @default.
• W2130481749 hasConceptScore W2130481749C139770010 @default.
• W2130481749 hasConceptScore W2130481749C1491633281 @default.
• W2130481749 hasConceptScore W2130481749C156407911 @default.
• W2130481749 hasConceptScore W2130481749C202751555 @default.

• next