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• W2130483985 abstract "We demonstrate that disulfide bond replacement is an efficient strategy for engineering therapeutic peptides. In previous work, short peptide fragments, known as WP9QY, with sequence homology with the predicted ligand contact surface of the receptor activator of NF-κB (RANK) were crosslinked through intramolecular disulfide bonds to inhibit RANK ligand (RANKL)-induced signaling, osteoclastogenesis, bone resorption in vitro, and bone loss in vivo. We report that replacement of the disulfide bond of WP9QY with an amine cross-linkage results in a significant improvement in enzymatic stability, with only a slight loss of bone resorption-blocking activity in vitro. Furthermore, the WP9QY derivative inhibits bone loss significantly in vivo, whereas the native form of WP9QY was not effective under the same conditions." @default.
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• W2130483985 date "2014-10-01" @default.
• W2130483985 modified "2023-09-23" @default.
• W2130483985 title "A disulfide bond replacement strategy enables the efficient design of artificial therapeutic peptides" @default.
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• W2130483985 doi "https://doi.org/10.1016/j.tet.2014.05.079" @default.
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