FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130484464> ?p ?o ?g. }

• W2130484464 endingPage "124" @default.
• W2130484464 startingPage "119" @default.
• W2130484464 abstract "Abstract Chronic lymphocytic leukemia (CLL) is characterized by a relatively small number of recurrent genetic defects. These can be evaluated by clinically available methods such as fluorescent in situ hybridization and targeted sequencing approaches to provide data that can be very helpful in prognostication and planning of treatment. Acquired defects in the p53 pathway, activating mutations of NOTCH1, and dysfunctional mutations of SF3B1 and BIRC3 identify patients with higher risk of progressive disease, poorer responses to conventional chemoimmunotherapy, and shorter survival. Risk stratification using these data can identify patients with aggressive CLL who require careful monitoring and are unlikely to have durable responses to chemoimmunotherapy at disease progression. Patients with defective DNA damage repair mechanisms because of p53 dysfunction should be considered for non-chemotherapy-based regimens including tyrosine kinase inhibitors, BCL2 inhibitors, monoclonal antibodies, and immunological therapies including allogeneic transplantation and chimeric antigen receptor-targeted T cells. Conversely, patients with no high-risk mutations can usually be monitored for a prolonged time and are likely to have durable responses to chemoimmunotherapy at disease progression. New technologies for genetic analysis such as targeted next-generation sequencing have the potential to make these analyses cheaper, faster, and more widely available. Comprehensive genetic analysis of patients both at diagnosis and before treatment for progressive disease could become an integral component of care for CLL." @default.
• W2130484464 created "2016-06-24" @default.
• W2130484464 creator A5007088786 @default.
• W2130484464 creator A5059451077 @default.
• W2130484464 date "2014-12-05" @default.
• W2130484464 modified "2023-10-17" @default.
• W2130484464 title "Mutations in chronic lymphocytic leukemia and how they affect therapy choice: focus on NOTCH1, SF3B1, and TP53" @default.
• W2130484464 cites W1971289548 @default.
• W2130484464 cites W1971447106 @default.
• W2130484464 cites W1979457403 @default.
• W2130484464 cites W1980260104 @default.
• W2130484464 cites W1990826225 @default.
• W2130484464 cites W1993355130 @default.
• W2130484464 cites W1996452057 @default.
• W2130484464 cites W1999233413 @default.
• W2130484464 cites W2008295869 @default.
• W2130484464 cites W2010779916 @default.
• W2130484464 cites W2011936456 @default.
• W2130484464 cites W2014952486 @default.
• W2130484464 cites W2015299436 @default.
• W2130484464 cites W2016042196 @default.
• W2130484464 cites W2020069805 @default.
• W2130484464 cites W2031121711 @default.
• W2130484464 cites W2033226263 @default.
• W2130484464 cites W2041978829 @default.
• W2130484464 cites W2043415097 @default.
• W2130484464 cites W2044433401 @default.
• W2130484464 cites W2049819517 @default.
• W2130484464 cites W2055148721 @default.
• W2130484464 cites W2061929146 @default.
• W2130484464 cites W2067064694 @default.
• W2130484464 cites W2069401990 @default.
• W2130484464 cites W2088580309 @default.
• W2130484464 cites W2091168608 @default.
• W2130484464 cites W2095969626 @default.
• W2130484464 cites W2096036897 @default.
• W2130484464 cites W2097017741 @default.
• W2130484464 cites W2101037187 @default.
• W2130484464 cites W2113895281 @default.
• W2130484464 cites W2116431837 @default.
• W2130484464 cites W2124920464 @default.
• W2130484464 cites W2135604149 @default.
• W2130484464 cites W2139777089 @default.
• W2130484464 cites W2145842706 @default.
• W2130484464 cites W2153442218 @default.
• W2130484464 cites W2164859876 @default.
• W2130484464 cites W2170340332 @default.
• W2130484464 cites W2170892717 @default.
• W2130484464 cites W2171443164 @default.
• W2130484464 cites W2318933236 @default.
• W2130484464 doi "https://doi.org/10.1182/asheducation-2014.1.119" @default.
• W2130484464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25696844" @default.
• W2130484464 hasPublicationYear "2014" @default.
• W2130484464 type Work @default.
• W2130484464 sameAs 2130484464 @default.
• W2130484464 citedByCount "19" @default.
• W2130484464 countsByYear W21304844642015 @default.
• W2130484464 countsByYear W21304844642017 @default.
• W2130484464 countsByYear W21304844642018 @default.
• W2130484464 countsByYear W21304844642019 @default.
• W2130484464 countsByYear W21304844642020 @default.
• W2130484464 countsByYear W21304844642021 @default.
• W2130484464 countsByYear W21304844642022 @default.
• W2130484464 crossrefType "journal-article" @default.
• W2130484464 hasAuthorship W2130484464A5007088786 @default.
• W2130484464 hasAuthorship W2130484464A5059451077 @default.
• W2130484464 hasBestOaLocation W21304844641 @default.
• W2130484464 hasConcept C113968399 @default.
• W2130484464 hasConcept C121608353 @default.
• W2130484464 hasConcept C126322002 @default.
• W2130484464 hasConcept C143998085 @default.
• W2130484464 hasConcept C203014093 @default.
• W2130484464 hasConcept C2777938653 @default.
• W2130484464 hasConcept C2778461978 @default.
• W2130484464 hasConcept C2778822529 @default.
• W2130484464 hasConcept C2779134260 @default.
• W2130484464 hasConcept C2780790343 @default.
• W2130484464 hasConcept C502942594 @default.
• W2130484464 hasConcept C71924100 @default.
• W2130484464 hasConceptScore W2130484464C113968399 @default.
• W2130484464 hasConceptScore W2130484464C121608353 @default.
• W2130484464 hasConceptScore W2130484464C126322002 @default.
• W2130484464 hasConceptScore W2130484464C143998085 @default.
• W2130484464 hasConceptScore W2130484464C203014093 @default.
• W2130484464 hasConceptScore W2130484464C2777938653 @default.
• W2130484464 hasConceptScore W2130484464C2778461978 @default.
• W2130484464 hasConceptScore W2130484464C2778822529 @default.
• W2130484464 hasConceptScore W2130484464C2779134260 @default.
• W2130484464 hasConceptScore W2130484464C2780790343 @default.
• W2130484464 hasConceptScore W2130484464C502942594 @default.
• W2130484464 hasConceptScore W2130484464C71924100 @default.
• W2130484464 hasIssue "1" @default.
• W2130484464 hasLocation W21304844641 @default.
• W2130484464 hasLocation W21304844642 @default.
• W2130484464 hasOpenAccess W2130484464 @default.
• W2130484464 hasPrimaryLocation W21304844641 @default.
• W2130484464 hasRelatedWork W2142422850 @default.
• W2130484464 hasRelatedWork W2169430085 @default.

• next