FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130484730> ?p ?o ?g. }

• W2130484730 endingPage "615" @default.
• W2130484730 startingPage "607" @default.
• W2130484730 abstract "Cannabis use is a hypothesized gateway to subsequent abuse of other drugs such as heroin. We currently assessed whether Δ-9-tetrahydrocannabinol (THC) exposure during adolescence modulates opiate reinforcement and opioid neural systems in adulthood. Long–Evan male rats received THC (1.5 mg/kg intraperitoneally (i.p.)) or vehicle every third day during postnatal days (PNDs) 28–49. Heroin self-administration behavior (fixed ratio-1; 3-h sessions) was studied from young adulthood (PND 57) into full adults (PND 102). THC-pretreated rats showed an upward shift throughout the heroin self-administration acquisition (30 μg/kg/infusion) phase, whereas control animals maintained the same pattern once stable intake was obtained. Heightened opiate sensitivity in THC animals was also evidenced by higher heroin consumption during the maintenance phase (30 and 60 μg/kg/infusion) and greater responding for moderate–low heroin doses (dose–response curve: 7.5, 15, 30, 60, and 100 μg/kg/injection). Specific disturbance of the endogenous opioid system was also apparent in the brain of adults with adolescent THC exposure. Striatal preproenkephalin mRNA expression was exclusively increased in the nucleus accumbens (NAc) shell; the relative elevation of preproenkephalin mRNA in the THC rats was maintained even after heroin self-administration. Moreover, μ opioid receptor (μOR) GTP-coupling was potentiated in mesolimbic and nigrostriatal brainstem regions in THC-pretreated animals. μOR function in the NAc shell was specifically correlated to heroin intake. The current findings support the gateway hypothesis demonstrating that adolescence cannabis exposure has an enduring impact on hedonic processing resulting in enhanced opiate intake, possibly as a consequence of alterations in limbic opioid neuronal populations." @default.
• W2130484730 created "2016-06-24" @default.
• W2130484730 creator A5022983132 @default.
• W2130484730 creator A5041986050 @default.
• W2130484730 creator A5083825817 @default.
• W2130484730 date "2006-07-05" @default.
• W2130484730 modified "2023-10-10" @default.
• W2130484730 title "Adolescent Cannabis Exposure Alters Opiate Intake and Opioid Limbic Neuronal Populations in Adult Rats" @default.
• W2130484730 cites W1699530412 @default.
• W2130484730 cites W1945938111 @default.
• W2130484730 cites W1965119856 @default.
• W2130484730 cites W1965511684 @default.
• W2130484730 cites W1965679449 @default.
• W2130484730 cites W1969199559 @default.
• W2130484730 cites W1970071373 @default.
• W2130484730 cites W1970870427 @default.
• W2130484730 cites W1985645068 @default.
• W2130484730 cites W1989416066 @default.
• W2130484730 cites W1990900400 @default.
• W2130484730 cites W1999561105 @default.
• W2130484730 cites W2019288562 @default.
• W2130484730 cites W2030310872 @default.
• W2130484730 cites W2040925146 @default.
• W2130484730 cites W2056974665 @default.
• W2130484730 cites W2064981998 @default.
• W2130484730 cites W2084024459 @default.
• W2130484730 cites W2086781281 @default.
• W2130484730 cites W2093604260 @default.
• W2130484730 cites W2103177499 @default.
• W2130484730 cites W2103903337 @default.
• W2130484730 cites W2108264967 @default.
• W2130484730 cites W2111641138 @default.
• W2130484730 cites W2120095635 @default.
• W2130484730 cites W2122251240 @default.
• W2130484730 cites W2123412635 @default.
• W2130484730 cites W2127378453 @default.
• W2130484730 cites W2133632803 @default.
• W2130484730 cites W2135903564 @default.
• W2130484730 cites W2135962544 @default.
• W2130484730 cites W2136468829 @default.
• W2130484730 cites W2146938761 @default.
• W2130484730 cites W2148399921 @default.
• W2130484730 cites W2152911335 @default.
• W2130484730 cites W2154438786 @default.
• W2130484730 cites W2156019215 @default.
• W2130484730 cites W2169863475 @default.
• W2130484730 cites W2171584675 @default.
• W2130484730 cites W2319939187 @default.
• W2130484730 cites W4322703236 @default.
• W2130484730 doi "https://doi.org/10.1038/sj.npp.1301127" @default.
• W2130484730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16823391" @default.
• W2130484730 hasPublicationYear "2006" @default.
• W2130484730 type Work @default.
• W2130484730 sameAs 2130484730 @default.
• W2130484730 citedByCount "257" @default.
• W2130484730 countsByYear W21304847302012 @default.
• W2130484730 countsByYear W21304847302013 @default.
• W2130484730 countsByYear W21304847302014 @default.
• W2130484730 countsByYear W21304847302015 @default.
• W2130484730 countsByYear W21304847302016 @default.
• W2130484730 countsByYear W21304847302017 @default.
• W2130484730 countsByYear W21304847302018 @default.
• W2130484730 countsByYear W21304847302019 @default.
• W2130484730 countsByYear W21304847302020 @default.
• W2130484730 countsByYear W21304847302021 @default.
• W2130484730 countsByYear W21304847302022 @default.
• W2130484730 countsByYear W21304847302023 @default.
• W2130484730 crossrefType "journal-article" @default.
• W2130484730 hasAuthorship W2130484730A5022983132 @default.
• W2130484730 hasAuthorship W2130484730A5041986050 @default.
• W2130484730 hasAuthorship W2130484730A5083825817 @default.
• W2130484730 hasBestOaLocation W21304847301 @default.
• W2130484730 hasConcept C118552586 @default.
• W2130484730 hasConcept C126322002 @default.
• W2130484730 hasConcept C134018914 @default.
• W2130484730 hasConcept C15744967 @default.
• W2130484730 hasConcept C170493617 @default.
• W2130484730 hasConcept C2776552330 @default.
• W2130484730 hasConcept C2777056318 @default.
• W2130484730 hasConcept C2778140631 @default.
• W2130484730 hasConcept C2778555786 @default.
• W2130484730 hasConcept C2778903686 @default.
• W2130484730 hasConcept C2780035454 @default.
• W2130484730 hasConcept C2780871563 @default.
• W2130484730 hasConcept C2781063702 @default.
• W2130484730 hasConcept C2909767651 @default.
• W2130484730 hasConcept C529278444 @default.
• W2130484730 hasConcept C71924100 @default.
• W2130484730 hasConcept C98274493 @default.
• W2130484730 hasConceptScore W2130484730C118552586 @default.
• W2130484730 hasConceptScore W2130484730C126322002 @default.
• W2130484730 hasConceptScore W2130484730C134018914 @default.
• W2130484730 hasConceptScore W2130484730C15744967 @default.
• W2130484730 hasConceptScore W2130484730C170493617 @default.
• W2130484730 hasConceptScore W2130484730C2776552330 @default.
• W2130484730 hasConceptScore W2130484730C2777056318 @default.
• W2130484730 hasConceptScore W2130484730C2778140631 @default.
• W2130484730 hasConceptScore W2130484730C2778555786 @default.

• next