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- W2130485951 abstract "Daily-life stress sensitivity is associated with depression, but prospective data are lacking.To examine associations between baseline ecological daily-life stress sensitivity and later depression, and to identify genetic and non-genetic factors moderating the transition from stress sensitivity to depression.Daily-life stress sensitivity was assessed at baseline in twins (n = 502). One baseline and four follow-up measurements of depressive symptoms and negative life events were collected, as well as interview-based diagnoses at baseline and last follow-up. Hypothesised genetic markers were determined.Baseline stress sensitivity was associated with increased depressive symptoms at follow-up and risk of major depressive disorder. Both genetic liability and major life events moderated the probability of transition from stress sensitivity to depression.Onset of depression is attributable to pre-onset ecological measurements of stress sensitivity, particularly where genetic liability is high and individuals have reached a stage where the influence of competing environmental causes is low." @default.
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- W2130485951 date "2009-12-01" @default.
- W2130485951 modified "2023-10-13" @default.
- W2130485951 title "Transition from stress sensitivity to a depressive state: longitudinal twin study" @default.
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- W2130485951 doi "https://doi.org/10.1192/bjp.bp.108.056853" @default.
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