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• W2130486822 endingPage "3399" @default.
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• W2130486822 abstract "The maturation of retinal ganglion cell (RGC) axon projections in the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) relies on both molecular and activity-dependent mechanisms. Despite the increasing popularity of the mouse as a mammalian visual system model, little is known in this species about the normal development of individual RGC axon arbors or the role of activity in this process. We used a novel in vivo single RGC labeling technique to quantitatively characterize the elaboration and refinement of RGC axon arbors in the dLGN and SC in wild-type (WT) and β2–nicotinic acetylcholine receptors mutant (β2 −/− ) mice, which have perturbed retinal waves, during the developmental period when eye-specific lamination and retinotopic refinement occurs. Our results suggest that eye-specific segregation and retinotopic refinement in WT mice are not the result of refinement of richly exuberant arbors but rather the elaboration of arbors prepositioned in the proper location combined with the elimination of inappropriately targeted sparse branches. We found that retinocollicular arbors mature ∼1 week earlier than retinogeniculate arbors, although RGC axons reach the dLGN and SC at roughly the same age. We also observed striking differences between contralateral and ipsilateral RGC axon arbors in the SC but not in the LGN. These data suggest a strong influence of target specific cues during arbor maturation. In β2 −/− mice, we found that retinofugal single axon arbors are well ramified but enlarged, particularly in the SC, indicating that activity-dependent visual map development occurs through the refinement of individual RGC arbors." @default.
• W2130486822 created "2016-06-24" @default.
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• W2130486822 date "2011-03-02" @default.
• W2130486822 modified "2023-10-12" @default.
• W2130486822 title "Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice" @default.
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• W2130486822 doi "https://doi.org/10.1523/jneurosci.4899-10.2011" @default.
• W2130486822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3060716" @default.
• W2130486822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21368050" @default.
• W2130486822 hasPublicationYear "2011" @default.
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