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• W2130489570 abstract "Proteoglycans were extracted and purified without dissociation (a-A1 preparations) from superficial and deeper layers of high weight-bearing (HWA) and low weight-bearing (LWA) areas of dog normal articular cartilage. These proteoglycans were then characterized by velocity gradient centrifugation. In each of the 4 different topographical regions, the weight average sedimentation coefficients related strongly with total hexuronate content of the tissue. In the superficial layers, almost all aggregates had low sedimentation coefficients: the aggregates were smaller and less abundant in LWA than in HWA. The deeper layers contained an additional population of faster sedimenting aggregates which appeared smaller and less abundant in LWA than in HWA. Quantification and functional characterization of aggregates as well as in vitro aggregating studies showed that the topographical differences in size and content of aggregates were related to differences in content of hyaluronate and link protein in the a-Al preparations. Superficial a-Al specimens contained twice as much hyaluronate as deeper a-Al preparations and their hyaluronate content increased with degree of physiological stress. Deeper a-Al specimens from weight-bearing areas did not differ in their hyaluronate content but experiments assessing the saturation with link protein of these different a-A1 preparations suggested that specimens from HWA contained more active link than those from LWA. In contrast, the capacity of aggregation of a-AIDI DI proteoglycan monomers as well as the molecular weight (Mr = 5 × 105) and aggregating capacity of hyluronate molecules appeared very similar in all a-Al preparations from areas of articular cartilage. It is hypothesized that the synthesis of the three constituents necessary for aggregate formation (i.e. proteoglycan monomers as well as hyaluronate and link protein molecules) increases with degree of physiological load and that aggregation helps to maintain within cartilage the high concentration of proteoglycans that are essential for its biomechanical functions. The reported topographical variations in the distribution of proteoglycan aggregates reflect probably a maximal adaptation of the physiologic and biomechanical properties of the matrix to meet the high stress levels experienced by the articular cartilage in vivo." @default.
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• W2130489570 date "1991-01-01" @default.
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• W2130489570 title "Proteoglycans Nondissociatively Extracted from Different Zones of Canine Normal Articular Cartilage: Variations in the Sedimentation Profile of Aggregates with Degree of Physiological Stress" @default.
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• W2130489570 doi "https://doi.org/10.3109/03008209109152441" @default.
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