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- W2130491135 abstract "Abstract Kinetic experiments have been made with three structurally related compounds selected from a series of bicyclic antidepressant compounds. Plasma concentrations were assayed after doses of 5 mg kg−1 given as an intravenous infusion over 2 h to three dogs. The data were evaluated according to a two compartment open model, and kinetic parameters reflecting distribution and elimination characteristics of the drugs were calculated. An attempt was made to evaluate possible relations between chemical structure and these parameters. The lowest drug levels and the most rapid elimination were obtained with a compound utilizing sulphoxidation as an additional pathway of metabolism. The compounds lacking this possibility had considerably slower elimination kinetics, the less lipophilic being the slowest one. Little individual variation was seen. A relation between increased lipophilicity and increased localization in the peripheral compartment was indicated. However, the importance of other factors, such as binding phenomena within tissues, was also indicated." @default.
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- W2130491135 date "1973-12-01" @default.
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- W2130491135 title "Kinetics of three structurally related bicyclic antidepressant compounds—a comparison in the dog" @default.
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- W2130491135 doi "https://doi.org/10.1111/j.2042-7158.1973.tb09986.x" @default.
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