Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130510959> ?p ?o ?g. }
- W2130510959 endingPage "17002" @default.
- W2130510959 startingPage "16992" @default.
- W2130510959 abstract "Reproduction in mammals is dependent on the function of hypothalamic neurons whose axons project to the hypothalamic median eminence (ME) where they release gonadotropin-releasing hormone (GnRH) into a specialized capillary network for delivery to the anterior pituitary. These neurons originate prenatally in the nasal placode and migrate into the forebrain along the olfactory-vomeronasal nerves. The complex developmental events leading to the correct establishment of the GnRH system are tightly regulated by the specific spatiotemporal expression patterns of guidance cues and extracellular matrix molecules, the functions of which, in part, are mediated by their binding to β1-subunit-containing integrins. To determine the biological role of these cell-surface proteins in reproduction, Cre/LoxP technology was used to generate GnRH neuron-specific β1-integrin conditional KO (GnRH-Itgb1(-/-)) mice. Loss of β1-integrin signaling impaired migration of GnRH neurons, their axonal extension to the ME, timing of pubertal onset, and fertility in these mice. These results identify β1-integrin as a gene involved in normal development of the GnRH system and demonstrate a fundamental role for this protein in acquisition of normal reproductive competence in female mice." @default.
- W2130510959 created "2016-06-24" @default.
- W2130510959 creator A5001998180 @default.
- W2130510959 creator A5014100676 @default.
- W2130510959 creator A5030288066 @default.
- W2130510959 creator A5035095591 @default.
- W2130510959 creator A5058705393 @default.
- W2130510959 creator A5062988886 @default.
- W2130510959 creator A5071208511 @default.
- W2130510959 creator A5083058332 @default.
- W2130510959 date "2012-11-21" @default.
- W2130510959 modified "2023-09-26" @default.
- W2130510959 title "Suppression of β1-Integrin in Gonadotropin-Releasing Hormone Cells Disrupts Migration and Axonal Extension Resulting in Severe Reproductive Alterations" @default.
- W2130510959 cites W1158998567 @default.
- W2130510959 cites W1415283250 @default.
- W2130510959 cites W1510791389 @default.
- W2130510959 cites W1535510845 @default.
- W2130510959 cites W1554147846 @default.
- W2130510959 cites W1576773659 @default.
- W2130510959 cites W1891662809 @default.
- W2130510959 cites W1966194315 @default.
- W2130510959 cites W1966564940 @default.
- W2130510959 cites W1967552317 @default.
- W2130510959 cites W1969901497 @default.
- W2130510959 cites W1971019443 @default.
- W2130510959 cites W1979274617 @default.
- W2130510959 cites W1979969794 @default.
- W2130510959 cites W1985180469 @default.
- W2130510959 cites W1986161032 @default.
- W2130510959 cites W1992291674 @default.
- W2130510959 cites W1993957466 @default.
- W2130510959 cites W1996691843 @default.
- W2130510959 cites W1998123755 @default.
- W2130510959 cites W1998286971 @default.
- W2130510959 cites W1998382665 @default.
- W2130510959 cites W1998974693 @default.
- W2130510959 cites W2012070523 @default.
- W2130510959 cites W2012993000 @default.
- W2130510959 cites W2019903295 @default.
- W2130510959 cites W2019914463 @default.
- W2130510959 cites W2029618197 @default.
- W2130510959 cites W2032161027 @default.
- W2130510959 cites W2032391479 @default.
- W2130510959 cites W2039083253 @default.
- W2130510959 cites W2041795914 @default.
- W2130510959 cites W2050014442 @default.
- W2130510959 cites W2054695954 @default.
- W2130510959 cites W2057055433 @default.
- W2130510959 cites W2058624823 @default.
- W2130510959 cites W2061075153 @default.
- W2130510959 cites W2062966472 @default.
- W2130510959 cites W2065118621 @default.
- W2130510959 cites W2070305198 @default.
- W2130510959 cites W2070887969 @default.
- W2130510959 cites W2079808326 @default.
- W2130510959 cites W2080306322 @default.
- W2130510959 cites W2085052924 @default.
- W2130510959 cites W2092224562 @default.
- W2130510959 cites W2104394703 @default.
- W2130510959 cites W2107012136 @default.
- W2130510959 cites W2107916607 @default.
- W2130510959 cites W2114506814 @default.
- W2130510959 cites W2115973220 @default.
- W2130510959 cites W2117856002 @default.
- W2130510959 cites W2122706104 @default.
- W2130510959 cites W2124121505 @default.
- W2130510959 cites W2128349355 @default.
- W2130510959 cites W2132314184 @default.
- W2130510959 cites W2136147511 @default.
- W2130510959 cites W2137230105 @default.
- W2130510959 cites W2138559670 @default.
- W2130510959 cites W2141115613 @default.
- W2130510959 cites W2144727302 @default.
- W2130510959 cites W2162544707 @default.
- W2130510959 cites W2165823177 @default.
- W2130510959 cites W4232297333 @default.
- W2130510959 cites W4234715034 @default.
- W2130510959 cites W4235477186 @default.
- W2130510959 doi "https://doi.org/10.1523/jneurosci.3057-12.2012" @default.
- W2130510959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5238668" @default.
- W2130510959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23175850" @default.
- W2130510959 hasPublicationYear "2012" @default.
- W2130510959 type Work @default.
- W2130510959 sameAs 2130510959 @default.
- W2130510959 citedByCount "31" @default.
- W2130510959 countsByYear W21305109592013 @default.
- W2130510959 countsByYear W21305109592014 @default.
- W2130510959 countsByYear W21305109592015 @default.
- W2130510959 countsByYear W21305109592016 @default.
- W2130510959 countsByYear W21305109592017 @default.
- W2130510959 countsByYear W21305109592018 @default.
- W2130510959 countsByYear W21305109592019 @default.
- W2130510959 countsByYear W21305109592020 @default.
- W2130510959 countsByYear W21305109592021 @default.
- W2130510959 countsByYear W21305109592022 @default.
- W2130510959 crossrefType "journal-article" @default.
- W2130510959 hasAuthorship W2130510959A5001998180 @default.
- W2130510959 hasAuthorship W2130510959A5014100676 @default.