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• W2130526971 abstract "Patients with cystic fibrosis (CF) are underweight and growth retarded. This study tested the link between serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) levels and body height, nutritional status, pulmonary function tests and activity of inflammation in 92 subjects with CF (age 2.1–18.8 y). It also analysed the effect of short-term antibiotic treatment and hyperalimentation on IGF-I and IGFBP-3 levels in 33 subjects (age 3.6–33.7 y) on 41 occasions. Both IGF-I (-1.19 ±0.17 SD) and IGFBP-3 levels (-0.66 ±0.12 SD; both p 0.0001 vs 0) were decreased in cross-sectional measurements. Their standardized values were inversely proportional to age (IGF-I: r= -0.23, p= 0.03; IGFBP-3: r= -0.29, p= 0.005) and positively correlated with SDS of height (IGF-I: r= 0.40, p 0.0001; IGFBP-3: r= 0.36, p= 0.0005) and of mid-arm circumference (IGF-I: r= 0.39, p= 0.0001; IGFBP-3: r= 0.38, p= 0.0002), and with pulmonary function tests. After a short-term course of intensive antibiotic therapy and hyperalimentation, IGF-I normalized (from -0.66 ± 0.20 to 0.00 ± 0.25 SD; pľ 0 0001) and IGFBP-3 increased (from -0.78 ± 0.15 to -0.53 ± 0.16 SD; p= 0.002). IGFBP-3 correlated inversely with erythrocyte sedimentation rate (r= -0.40, p= 0.01). Conclusion: The levels of IGF-I and IGFBP-3 are markedly decreased in patients with CF and tend to normalise after a short course of antibiotic treatment and hyperalimentation." @default.
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• W2130526971 date "2001-08-01" @default.
• W2130526971 modified "2023-09-25" @default.
• W2130526971 title "Insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in cystic fibrosis: a positive effect of antibiotic therapy and hyperalimentation" @default.
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• W2130526971 doi "https://doi.org/10.1111/j.1651-2227.2001.tb02447.x" @default.
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