FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130527720> ?p ?o ?g. }

• W2130527720 endingPage "G786" @default.
• W2130527720 startingPage "G778" @default.
• W2130527720 abstract "Mesenchymal stem cells (MSCs), a subpopulation of adult somatic stem cells, are an attractive stem cell source in regenerative medicine because of their multipotentiality. We examined the effects of MSC transplantation on gastric ulcer healing. Putative MSCs, isolated from bone marrow aspirates of male rats by dish adherence and expanded in culture, were characterized by flow cytometry and reverse transcription-polymerase chain reaction. Gastric ulcers were induced by serosal application of acetic acid on the anterior wall of the stomach in female rats. Either MSCs (labeled with PKH67; 1×10 7 cells) or vehicle was injected into the gastric wall surrounding the ulcer. The healing process of the ulcer and the influence of anti-vascular endothelial growth factor (VEGF) antibody were examined. CD29-positive, CD90-positive, CD34-negative, and CD45-negative MSCs expressed mRNAs for VEGF and hepatocyte growth factor (HGF). The MSCs were transplantable to the gastric tissue surrounding the ulcer, where a majority of the engrafted cells were positive for vimentin. The transplantation significantly accelerated gastric ulcer healing compared with controls. The engrafted MSCs also expressed VEGF and HGF. Administration of anti-VEGF neutralizing antibody dose dependently reduced the MSC-induced promotion of ulcer healing. In conclusion, MSC transplantation accelerated gastric ulcer healing, possibly through the induction of angiogenesis in the gastric mucosa via the secretion of VEGF. The beneficial effects of MSCs might be mediated not only by their differentiation into gastric interstitial cells, but also by their ability to supply angiogenic factors." @default.
• W2130527720 created "2016-06-24" @default.
• W2130527720 creator A5014582936 @default.
• W2130527720 creator A5022752354 @default.
• W2130527720 creator A5029191285 @default.
• W2130527720 creator A5031879463 @default.
• W2130527720 creator A5042725263 @default.
• W2130527720 creator A5051625411 @default.
• W2130527720 creator A5060389174 @default.
• W2130527720 creator A5060744842 @default.
• W2130527720 creator A5065377682 @default.
• W2130527720 creator A5080369708 @default.
• W2130527720 creator A5080491465 @default.
• W2130527720 date "2008-03-01" @default.
• W2130527720 modified "2023-09-23" @default.
• W2130527720 title "Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats" @default.
• W2130527720 cites W1962896803 @default.
• W2130527720 cites W1965198398 @default.
• W2130527720 cites W1965953554 @default.
• W2130527720 cites W1992381980 @default.
• W2130527720 cites W1993703800 @default.
• W2130527720 cites W2000462703 @default.
• W2130527720 cites W2004413672 @default.
• W2130527720 cites W2012890384 @default.
• W2130527720 cites W2013991912 @default.
• W2130527720 cites W2015542374 @default.
• W2130527720 cites W2032761083 @default.
• W2130527720 cites W2040024535 @default.
• W2130527720 cites W2060146566 @default.
• W2130527720 cites W2075365946 @default.
• W2130527720 cites W2079415770 @default.
• W2130527720 cites W2082243343 @default.
• W2130527720 cites W2089397149 @default.
• W2130527720 cites W2106673834 @default.
• W2130527720 cites W2119774673 @default.
• W2130527720 cites W2128192010 @default.
• W2130527720 cites W2129220284 @default.
• W2130527720 cites W2145952115 @default.
• W2130527720 cites W2148134181 @default.
• W2130527720 cites W2150500797 @default.
• W2130527720 cites W2159999899 @default.
• W2130527720 cites W2161820725 @default.
• W2130527720 cites W4243820570 @default.
• W2130527720 doi "https://doi.org/10.1152/ajpgi.00468.2007" @default.
• W2130527720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18202110" @default.
• W2130527720 hasPublicationYear "2008" @default.
• W2130527720 type Work @default.
• W2130527720 sameAs 2130527720 @default.
• W2130527720 citedByCount "40" @default.
• W2130527720 countsByYear W21305277202012 @default.
• W2130527720 countsByYear W21305277202013 @default.
• W2130527720 countsByYear W21305277202014 @default.
• W2130527720 countsByYear W21305277202015 @default.
• W2130527720 countsByYear W21305277202016 @default.
• W2130527720 countsByYear W21305277202018 @default.
• W2130527720 countsByYear W21305277202019 @default.
• W2130527720 countsByYear W21305277202020 @default.
• W2130527720 countsByYear W21305277202021 @default.
• W2130527720 countsByYear W21305277202022 @default.
• W2130527720 countsByYear W21305277202023 @default.
• W2130527720 crossrefType "journal-article" @default.
• W2130527720 hasAuthorship W2130527720A5014582936 @default.
• W2130527720 hasAuthorship W2130527720A5022752354 @default.
• W2130527720 hasAuthorship W2130527720A5029191285 @default.
• W2130527720 hasAuthorship W2130527720A5031879463 @default.
• W2130527720 hasAuthorship W2130527720A5042725263 @default.
• W2130527720 hasAuthorship W2130527720A5051625411 @default.
• W2130527720 hasAuthorship W2130527720A5060389174 @default.
• W2130527720 hasAuthorship W2130527720A5060744842 @default.
• W2130527720 hasAuthorship W2130527720A5065377682 @default.
• W2130527720 hasAuthorship W2130527720A5080369708 @default.
• W2130527720 hasAuthorship W2130527720A5080491465 @default.
• W2130527720 hasConcept C10205521 @default.
• W2130527720 hasConcept C116716535 @default.
• W2130527720 hasConcept C126322002 @default.
• W2130527720 hasConcept C142724271 @default.
• W2130527720 hasConcept C167734588 @default.
• W2130527720 hasConcept C170493617 @default.
• W2130527720 hasConcept C198826908 @default.
• W2130527720 hasConcept C203014093 @default.
• W2130527720 hasConcept C2776996007 @default.
• W2130527720 hasConcept C2777025900 @default.
• W2130527720 hasConcept C2780269544 @default.
• W2130527720 hasConcept C2780394083 @default.
• W2130527720 hasConcept C28328180 @default.
• W2130527720 hasConcept C2911091166 @default.
• W2130527720 hasConcept C502942594 @default.
• W2130527720 hasConcept C71924100 @default.
• W2130527720 hasConcept C86803240 @default.
• W2130527720 hasConcept C95444343 @default.
• W2130527720 hasConceptScore W2130527720C10205521 @default.
• W2130527720 hasConceptScore W2130527720C116716535 @default.
• W2130527720 hasConceptScore W2130527720C126322002 @default.
• W2130527720 hasConceptScore W2130527720C142724271 @default.
• W2130527720 hasConceptScore W2130527720C167734588 @default.
• W2130527720 hasConceptScore W2130527720C170493617 @default.
• W2130527720 hasConceptScore W2130527720C198826908 @default.
• W2130527720 hasConceptScore W2130527720C203014093 @default.

• next