Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130532370> ?p ?o ?g. }
- W2130532370 endingPage "186" @default.
- W2130532370 startingPage "179" @default.
- W2130532370 abstract "NCoA62/SKIP was discovered as a nuclear protein that interacts with the Vitamin D receptor (VDR) and the SKI oncoprotein. NCoA62/SKIP expresses properties consistent with other nuclear receptor transcriptional coactivator proteins. For example, NCoA62/SKIP interacts selectively with the VDR–RXR heterodimer, it forms a ternary complex with liganded VDR and steroid receptor coactivator (SRC) proteins, and it synergizes with SRCs to augment 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]- and VDR-activated transcription. Chromatin immunoprecipitation studies show that NCoA62/SKIP is recruited in a 1,25-(OH)2D3-dependent manner to native Vitamin D responsive gene promoters and it enters these promoter complexes after VDR and SRC entry. This suggests that NCoA62/SKIP functions at a distal step in the transactivation process. Recent studies indicate that NCoA62/SKIP is a component of the spliceosome machinery and interacts with important splicing factors such as prp8 and the U5 200 kDa helicase. Functional studies also support an involvement of NCoA62/SKIP in mRNA splicing. Collectively, these data suggest a pivotal role for NCoA62/SKIP in coupling transcriptional regulation by VDR to RNA splicing. They further solidify an important role for VDR/NR-interactors downstream of the transcription process in determining the overall response of Vitamin D and steroid hormone regulated genes." @default.
- W2130532370 created "2016-06-24" @default.
- W2130532370 creator A5022786834 @default.
- W2130532370 creator A5029048966 @default.
- W2130532370 creator A5040062610 @default.
- W2130532370 creator A5088141052 @default.
- W2130532370 date "2004-05-01" @default.
- W2130532370 modified "2023-10-16" @default.
- W2130532370 title "Emerging insights into the coactivator role of NCoA62/SKIP in Vitamin D-mediated transcription" @default.
- W2130532370 cites W1493268813 @default.
- W2130532370 cites W1501286679 @default.
- W2130532370 cites W1546538401 @default.
- W2130532370 cites W1582290662 @default.
- W2130532370 cites W1590197184 @default.
- W2130532370 cites W1592803732 @default.
- W2130532370 cites W1593089530 @default.
- W2130532370 cites W1646199134 @default.
- W2130532370 cites W1969076105 @default.
- W2130532370 cites W1971657931 @default.
- W2130532370 cites W1975600010 @default.
- W2130532370 cites W1977854547 @default.
- W2130532370 cites W1981022538 @default.
- W2130532370 cites W1988904557 @default.
- W2130532370 cites W1990529844 @default.
- W2130532370 cites W1996127793 @default.
- W2130532370 cites W1996785396 @default.
- W2130532370 cites W1997290172 @default.
- W2130532370 cites W2003002984 @default.
- W2130532370 cites W2004295929 @default.
- W2130532370 cites W2006931677 @default.
- W2130532370 cites W2009609922 @default.
- W2130532370 cites W2010159589 @default.
- W2130532370 cites W2019757555 @default.
- W2130532370 cites W2022110250 @default.
- W2130532370 cites W2026561146 @default.
- W2130532370 cites W2030640098 @default.
- W2130532370 cites W2033714991 @default.
- W2130532370 cites W2036684049 @default.
- W2130532370 cites W2039022971 @default.
- W2130532370 cites W2039887170 @default.
- W2130532370 cites W2056635197 @default.
- W2130532370 cites W2068113812 @default.
- W2130532370 cites W2074424265 @default.
- W2130532370 cites W2080910217 @default.
- W2130532370 cites W2086908959 @default.
- W2130532370 cites W2089480603 @default.
- W2130532370 cites W2094221900 @default.
- W2130532370 cites W2107594198 @default.
- W2130532370 cites W2111650618 @default.
- W2130532370 cites W2113456624 @default.
- W2130532370 cites W2114764370 @default.
- W2130532370 cites W2118516988 @default.
- W2130532370 cites W2122014103 @default.
- W2130532370 cites W2141662437 @default.
- W2130532370 cites W2153161471 @default.
- W2130532370 cites W2154693798 @default.
- W2130532370 cites W278636550 @default.
- W2130532370 cites W4241870034 @default.
- W2130532370 cites W4246044874 @default.
- W2130532370 cites W4250695535 @default.
- W2130532370 doi "https://doi.org/10.1016/j.jsbmb.2004.03.097" @default.
- W2130532370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15225769" @default.
- W2130532370 hasPublicationYear "2004" @default.
- W2130532370 type Work @default.
- W2130532370 sameAs 2130532370 @default.
- W2130532370 citedByCount "35" @default.
- W2130532370 countsByYear W21305323702012 @default.
- W2130532370 countsByYear W21305323702013 @default.
- W2130532370 countsByYear W21305323702014 @default.
- W2130532370 countsByYear W21305323702015 @default.
- W2130532370 countsByYear W21305323702018 @default.
- W2130532370 countsByYear W21305323702022 @default.
- W2130532370 crossrefType "journal-article" @default.
- W2130532370 hasAuthorship W2130532370A5022786834 @default.
- W2130532370 hasAuthorship W2130532370A5029048966 @default.
- W2130532370 hasAuthorship W2130532370A5040062610 @default.
- W2130532370 hasAuthorship W2130532370A5088141052 @default.
- W2130532370 hasConcept C101762097 @default.
- W2130532370 hasConcept C104317684 @default.
- W2130532370 hasConcept C124170894 @default.
- W2130532370 hasConcept C1292079 @default.
- W2130532370 hasConcept C134320426 @default.
- W2130532370 hasConcept C138885662 @default.
- W2130532370 hasConcept C150194340 @default.
- W2130532370 hasConcept C179639408 @default.
- W2130532370 hasConcept C179926584 @default.
- W2130532370 hasConcept C203966977 @default.
- W2130532370 hasConcept C40000846 @default.
- W2130532370 hasConcept C41895202 @default.
- W2130532370 hasConcept C54355233 @default.
- W2130532370 hasConcept C54458228 @default.
- W2130532370 hasConcept C63932345 @default.
- W2130532370 hasConcept C64350747 @default.
- W2130532370 hasConcept C67705224 @default.
- W2130532370 hasConcept C77445288 @default.
- W2130532370 hasConcept C86339819 @default.
- W2130532370 hasConcept C86803240 @default.
- W2130532370 hasConcept C95444343 @default.