FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130540738> ?p ?o ?g. }

• W2130540738 endingPage "1172" @default.
• W2130540738 startingPage "1159" @default.
• W2130540738 abstract "Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an oncofetal RNA-binding protein. IMP2 is doubly phosphorylated in a rapamycin-inhibitable, amino acid-dependent manner in cells and by mTOR in vitro. Double phosphorylation promotes IMP2 binding to the IGF2 leader 3 mRNA 5′ untranslated region, and the translational initiation of this mRNA through eIF-4E- and 5′ cap-independent internal ribosomal entry. Unexpectedly, the interaction of IMP2 with mTOR complex 1 occurs through mTOR itself rather than through raptor. Whereas depletion of mTOR strongly inhibits IMP2 phosphorylation in cells, comparable depletion of raptor has no effect; moreover, the ability of mTOR to phosphorylate IMP2 in vitro is unaffected by the elimination of raptor. Dual phosphorylation of IMP2 at the mTOR sites is evident in the mouse embryo, likely coupling nutrient sufficiency to IGF2 expression and fetal growth. Doubly phosphorylated IMP2 is also widely expressed in adult tissues, including islets of Langerhans." @default.
• W2130540738 created "2016-06-24" @default.
• W2130540738 creator A5003459148 @default.
• W2130540738 creator A5021306453 @default.
• W2130540738 creator A5024237923 @default.
• W2130540738 creator A5030952112 @default.
• W2130540738 creator A5031714701 @default.
• W2130540738 creator A5032212627 @default.
• W2130540738 date "2011-05-16" @default.
• W2130540738 modified "2023-09-30" @default.
• W2130540738 title "mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry" @default.
• W2130540738 cites W1540320516 @default.
• W2130540738 cites W1944558458 @default.
• W2130540738 cites W1965395430 @default.
• W2130540738 cites W1970949525 @default.
• W2130540738 cites W1972087054 @default.
• W2130540738 cites W1977893138 @default.
• W2130540738 cites W1984090022 @default.
• W2130540738 cites W2002031023 @default.
• W2130540738 cites W2002226709 @default.
• W2130540738 cites W2003241548 @default.
• W2130540738 cites W2012142261 @default.
• W2130540738 cites W2023012828 @default.
• W2130540738 cites W2025036829 @default.
• W2130540738 cites W2029213510 @default.
• W2130540738 cites W2047631029 @default.
• W2130540738 cites W2048755332 @default.
• W2130540738 cites W2050197492 @default.
• W2130540738 cites W2053003053 @default.
• W2130540738 cites W2066802199 @default.
• W2130540738 cites W2067918274 @default.
• W2130540738 cites W2071131807 @default.
• W2130540738 cites W2073482890 @default.
• W2130540738 cites W2075511135 @default.
• W2130540738 cites W2082122713 @default.
• W2130540738 cites W2083412264 @default.
• W2130540738 cites W2089481117 @default.
• W2130540738 cites W2091549056 @default.
• W2130540738 cites W2096513555 @default.
• W2130540738 cites W2097766475 @default.
• W2130540738 cites W2098912234 @default.
• W2130540738 cites W2100434800 @default.
• W2130540738 cites W2108163512 @default.
• W2130540738 cites W2110654245 @default.
• W2130540738 cites W2117720293 @default.
• W2130540738 cites W2136737818 @default.
• W2130540738 cites W2137118243 @default.
• W2130540738 cites W2138743983 @default.
• W2130540738 cites W2138998454 @default.
• W2130540738 cites W2150518523 @default.
• W2130540738 cites W2153497031 @default.
• W2130540738 cites W2154417257 @default.
• W2130540738 cites W2158111020 @default.
• W2130540738 cites W2166250242 @default.
• W2130540738 cites W2171280161 @default.
• W2130540738 cites W4244630643 @default.
• W2130540738 cites W59286015 @default.
• W2130540738 cites W68284179 @default.
• W2130540738 doi "https://doi.org/10.1101/gad.2042311" @default.
• W2130540738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3110954" @default.
• W2130540738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21576258" @default.
• W2130540738 hasPublicationYear "2011" @default.
• W2130540738 type Work @default.
• W2130540738 sameAs 2130540738 @default.
• W2130540738 citedByCount "146" @default.
• W2130540738 countsByYear W21305407382012 @default.
• W2130540738 countsByYear W21305407382013 @default.
• W2130540738 countsByYear W21305407382014 @default.
• W2130540738 countsByYear W21305407382015 @default.
• W2130540738 countsByYear W21305407382016 @default.
• W2130540738 countsByYear W21305407382017 @default.
• W2130540738 countsByYear W21305407382018 @default.
• W2130540738 countsByYear W21305407382019 @default.
• W2130540738 countsByYear W21305407382020 @default.
• W2130540738 countsByYear W21305407382021 @default.
• W2130540738 countsByYear W21305407382022 @default.
• W2130540738 countsByYear W21305407382023 @default.
• W2130540738 crossrefType "journal-article" @default.
• W2130540738 hasAuthorship W2130540738A5003459148 @default.
• W2130540738 hasAuthorship W2130540738A5021306453 @default.
• W2130540738 hasAuthorship W2130540738A5024237923 @default.
• W2130540738 hasAuthorship W2130540738A5030952112 @default.
• W2130540738 hasAuthorship W2130540738A5031714701 @default.
• W2130540738 hasAuthorship W2130540738A5032212627 @default.
• W2130540738 hasBestOaLocation W21305407381 @default.
• W2130540738 hasConcept C104202773 @default.
• W2130540738 hasConcept C104317684 @default.
• W2130540738 hasConcept C105580179 @default.
• W2130540738 hasConcept C11960822 @default.
• W2130540738 hasConcept C149364088 @default.
• W2130540738 hasConcept C150194340 @default.
• W2130540738 hasConcept C153911025 @default.
• W2130540738 hasConcept C2777949483 @default.
• W2130540738 hasConcept C2780926556 @default.
• W2130540738 hasConcept C38062823 @default.
• W2130540738 hasConcept C43060935 @default.
• W2130540738 hasConcept C55493867 @default.
• W2130540738 hasConcept C62478195 @default.

• next