FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130541746> ?p ?o ?g. }

• W2130541746 endingPage "396" @default.
• W2130541746 startingPage "385" @default.
• W2130541746 abstract "Brainstem catecholamine (CA) neurones have wide projections and an arousal-state-dependent activity pattern. They are thought to modulate the processing of sensory information and also participate in the control of breathing. Mice with lethal genetic defects that include CA neurones have abnormal respiratory control at birth. Also the A6 region (locus coeruleus), which contains CA neurones sensitive to CO(2) in vitro, is one of many putative central chemoreceptor sites. We studied the role of CA neurones in the control of breathing during sleep and wakefulness by specifically lesioning them with antidopamine beta-hydroxylase-saporin (DBH-SAP) injected via the 4th ventricle. After 3 weeks there was a 73-84% loss of A5, A6 and A7 tyrosine hydroxylase (TH) immunoreactive (ir) neurones along with 56-60% loss of C1 and C2 phenyl ethanolamine-N-methyltransferase (PNMT)-ir neurones. Over the 3 weeks, breathing frequency decreased significantly during air and 3 or 7% CO(2) breathing in both wakefulness and non-REM (NREM) sleep. The rats spent significantly less time awake and more time in NREM sleep. REM sleep time was unaffected. The ventilatory response to 7% CO(2) was reduced significantly in wakefulness at 7, 14 and 21 days (-28%) and in NREM sleep at 14 and 21 days (-26%). Breathing variability increased in REM sleep but not in wakefulness or NREM sleep. We conclude that CA neurones (1) promote wakefulness, (2) participate in central respiratory chemoreception, (3) stimulate breathing frequency, and (4) minimize breathing variability in REM sleep." @default.
• W2130541746 created "2016-06-24" @default.
• W2130541746 creator A5002976448 @default.
• W2130541746 creator A5087996267 @default.
• W2130541746 date "2006-01-01" @default.
• W2130541746 modified "2023-10-14" @default.
• W2130541746 title "Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability" @default.
• W2130541746 cites W1502160784 @default.
• W2130541746 cites W1606835851 @default.
• W2130541746 cites W1666135769 @default.
• W2130541746 cites W1750942102 @default.
• W2130541746 cites W1897009720 @default.
• W2130541746 cites W1963936141 @default.
• W2130541746 cites W1967180688 @default.
• W2130541746 cites W1968708464 @default.
• W2130541746 cites W1969576398 @default.
• W2130541746 cites W1970986757 @default.
• W2130541746 cites W1976132208 @default.
• W2130541746 cites W1977395856 @default.
• W2130541746 cites W1977546294 @default.
• W2130541746 cites W1983315545 @default.
• W2130541746 cites W1989184791 @default.
• W2130541746 cites W1995931872 @default.
• W2130541746 cites W1998349062 @default.
• W2130541746 cites W2003827347 @default.
• W2130541746 cites W2004642868 @default.
• W2130541746 cites W2006219353 @default.
• W2130541746 cites W2009978651 @default.
• W2130541746 cites W2011861384 @default.
• W2130541746 cites W2016014417 @default.
• W2130541746 cites W2016279918 @default.
• W2130541746 cites W2018008165 @default.
• W2130541746 cites W2021151952 @default.
• W2130541746 cites W2034277201 @default.
• W2130541746 cites W2045712239 @default.
• W2130541746 cites W2050538326 @default.
• W2130541746 cites W2063359735 @default.
• W2130541746 cites W2067934129 @default.
• W2130541746 cites W2071233773 @default.
• W2130541746 cites W2071629944 @default.
• W2130541746 cites W2072485127 @default.
• W2130541746 cites W2074548799 @default.
• W2130541746 cites W2078871099 @default.
• W2130541746 cites W2078965371 @default.
• W2130541746 cites W2083694208 @default.
• W2130541746 cites W2094316274 @default.
• W2130541746 cites W2094830056 @default.
• W2130541746 cites W2107135308 @default.
• W2130541746 cites W2113640125 @default.
• W2130541746 cites W2113966002 @default.
• W2130541746 cites W2120543763 @default.
• W2130541746 cites W2122206477 @default.
• W2130541746 cites W2129928127 @default.
• W2130541746 cites W2151314950 @default.
• W2130541746 cites W2157851792 @default.
• W2130541746 cites W2166483621 @default.
• W2130541746 cites W2186341992 @default.
• W2130541746 cites W2207334537 @default.
• W2130541746 cites W2270857655 @default.
• W2130541746 cites W2318508702 @default.
• W2130541746 cites W2333488718 @default.
• W2130541746 cites W2399259105 @default.
• W2130541746 doi "https://doi.org/10.1113/jphysiol.2005.099325" @default.
• W2130541746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1464315" @default.
• W2130541746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16254009" @default.
• W2130541746 hasPublicationYear "2006" @default.
• W2130541746 type Work @default.
• W2130541746 sameAs 2130541746 @default.
• W2130541746 citedByCount "116" @default.
• W2130541746 countsByYear W21305417462012 @default.
• W2130541746 countsByYear W21305417462013 @default.
• W2130541746 countsByYear W21305417462014 @default.
• W2130541746 countsByYear W21305417462015 @default.
• W2130541746 countsByYear W21305417462016 @default.
• W2130541746 countsByYear W21305417462017 @default.
• W2130541746 countsByYear W21305417462018 @default.
• W2130541746 countsByYear W21305417462019 @default.
• W2130541746 countsByYear W21305417462020 @default.
• W2130541746 countsByYear W21305417462021 @default.
• W2130541746 countsByYear W21305417462022 @default.
• W2130541746 countsByYear W21305417462023 @default.
• W2130541746 crossrefType "journal-article" @default.
• W2130541746 hasAuthorship W2130541746A5002976448 @default.
• W2130541746 hasAuthorship W2130541746A5087996267 @default.
• W2130541746 hasBestOaLocation W21305417462 @default.
• W2130541746 hasConcept C111919701 @default.
• W2130541746 hasConcept C123792249 @default.
• W2130541746 hasConcept C126322002 @default.
• W2130541746 hasConcept C134018914 @default.
• W2130541746 hasConcept C164854266 @default.
• W2130541746 hasConcept C169760540 @default.
• W2130541746 hasConcept C20566671 @default.
• W2130541746 hasConcept C2775841894 @default.
• W2130541746 hasConcept C2778468602 @default.
• W2130541746 hasConcept C2779213384 @default.
• W2130541746 hasConcept C2779320081 @default.
• W2130541746 hasConcept C41008148 @default.
• W2130541746 hasConcept C42219234 @default.

• next